Histamine H3 receptors modulate depolarization-evoked [3H]-noradrenaline release from rat olfactory bulb slices

The Histamine H3Receptor: Structure, Pharmacology, and Function

“…In rat cerebral slices and synaptosomes as well as in SNr slices, H 3 R activation inhibits 5-HT release evoked by electrical or chemical stimulation (Schlicker et al, 1988;Fink et al, 1990;Threlfell et al, 2004). By contrast, in rat olfactory bulb slices, H 3 R activation had no effect on depolarization-induced [ 3 H]-5-HT release (Aquino-Miranda et al, 2012).…”

“…For the CNS, in vitro experiments indicated that H 3 R activation reduces depolarization-induced [ 3 H]noradrenaline release in rodent cerebral cortex, spinal cord, cerebellum, hippocampus, hypothalamus and olfactory bulb, and human cerebral cortex (Schlicker et al, 1989(Schlicker et al, , 1992(Schlicker et al, , 1994(Schlicker et al, , 1999Celuch, 1995;Timm et al, 1998;Aquino-Miranda et al, 2012). In vivo microdialysis experiments showed that H 3 R activation reduces noradrenaline release in rat hippocampus and cerebral cortex (Di Carlo et al, 2000;Medhurst et al, 2007).…”

“…H 3 R-mediated inhibition of GABA release has been observed in vivo in rat medial vestibular nucleus and in vitro in primary cultures of rat cerebrocortical neurons and dissociated neurons from the rat hypothalamus ventromedial nucleus (Jang et al, 2001;Bergquist et al, 2006;Dai et al, 2007). In contrast, H 3 R activation does not modify depolarizationevoked [ 3 H]-GABA release from rat thalamus and olfactory bulb slices (Garduño-Torres et al, 2007;Aquino-Miranda et al, 2012), indicating that not all GABAergic neurons express presynaptic H 3 Rs.…”

Histamine H3 receptor activation inhibits dopamine synthesis but not release or uptake in rat nucleus accumbens

“…In several areas of the rat brain such as cerebral cortex, hippocampus, cerebellum and olfactory bulb, presynaptic H 3 Rs regulate noradrenaline release (Feuerstein, 2008;Osorio-Espinoza et al, 2010;Panula and Nuutinen, 2013;Aquino-Miranda et al, 2012). The NAcc receives noradrenergic projections (Sesack and Grace, 2010), and the inhibition of DOPA accumulation reported herein could have occurred thus in noradrenergic nerve terminals endowed with H 3 Rs.…”

Different processes lead to similar patterns: a test of codivergence and the role of sea level and climate changes in shaping a southern temperate freshwater assemblage

“…However, phylogeographic and phylogenetic studies of terrestrial and freshwater taxa in Chile and Argentina [15,16] are beginning to provide insights into the evolutionary history of this important region. Because aquatic diversity in Chile is relatively depauperate [17,18] examination of a few widespread can provide important insights into the evolutionary history of the region. For example, a phylogenetic study of freshwater crabs in the genus Aegla (Aeglidae: Anomura; [19,20] and a phylogeographic study of the freshwater catfish ( Trichomycterus areolatus : Trichomycteridae: Teleostei; [13] discovered similar levels of model-corrected genetic distance of mitochondrial lineages between Aegla (cytochrome oxidase I and II genes: 1598 base pairs) and Trichomycterus (cytochrome b: 1137 base pairs).…”