Histamine H1- and H2-receptors in coronary arteries of pigs

Hagen, Martine Elisabeth Kienzle; Paegelow, I.

doi:10.1007/bf01966697

Cited by 25 publications

(14 citation statements)

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“…2, the isolated pig and cattle coronary arteries were contracted by histamine. These results were similar to previous reports in pigs (12,13) and cattle (3,14). In pig coronary arteries, removal of the endothelium increased the maximal response and pD2 value of the histamine-induced contraction ( Fig.…”

Section: Discussionsupporting

confidence: 92%

“…7). These results are similar to those of Hagen and Paegelow (13). They have mentioned that histamine in pig coronary arteries exerts opposite actions, an H1-receptor-mediated contraction and an H2-receptor-mediated relaxation.…”

Section: Discussionsupporting

confidence: 90%

“…Histamine has been reported to contract pig and cattle coronary arteries in vitro (3,4,12,13), but there are few data about the subtypes of histamine receptors and whether vascular responses to histamine are endothelium-dependent or not in these species (12,13). As shown in Fig.…”

Section: Discussionmentioning

confidence: 99%

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Vasomotor effect of histamine on pig and cattle coronary artery in vitro.

Obi¹,

Matsumoto

Nishio

1991

Jpn.J.Pharmacol

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ABSTRACT-Vasomotor effects of histamine were examined in isolated coronary arteries from pigs and cattle. Histamine produced a concentration-dependent contraction in these arteries. These contractile responses were dose-dependently inhibited by diphenhydramine. The slopes of the Schild plots, however, were significantly lower than unity in both species. Cimetidine potentiated the histamine-induced contractions at relatively high doses of histamine (larger than 10-5 M) in pig coronary arteries, but did not show a significant effect in cattle arteries. After the removal of endothelium, the Schild plot of diphenhydramine against histamine gave a straight line with a pA2 value of 7.80 and slope of 1.00 in pigs, confirming the competitive nature of the antagonism. In cattle, the slope was significantly lower than unity; however, in the presence of cimetidine, it was not significantly different from unity. Dimaprit did not contract the cattle coronary arteries with endothelium, but contracted them after the removal of endothelium. These results suggest that histamine-induced vasoconstriction in pig and cattle coronary arteries is mainly dependent on the Hi-receptors in the smooth muscle cells, and that H1-and H2-receptors in the endothelial cells of pigs and H2-receptors in the smooth muscle cells of cattle modify the histamine-induced vasoconstrictions. Remarkable species differences have been reported concerning the responsiveness of coronary vessels to histamine in vitro. Coronary arteries from monkeys and dogs respond to histamine with relaxations (1, 2), while human, pig and cattle coronary arteries respond with contractions (3-6).It has been postulated that the species difference might depend on the ability of histamine to activate H1-and H2-receptors in vascular smooth muscle and H1-receptors in endothelium, which possibly mediate the release of prostaglandin 12 (7, 8) or endothelium-derived relaxing factors (1,9,10

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Vasomotor effect of histamine on pig and cattle coronary artery in vitro.

Obi¹,

Matsumoto

Nishio

1991

Jpn.J.Pharmacol

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“…Over the past few years, influences of histamine on cat and rat gastric (Guth & Smith, 1978a;Harvey, Owen & Shaw, 1980), rat, rabbit, cat and dog mesenteric (Flynn & Owen, 1975;Angus & Korner, 1977;Pawlik, Tague, Tepperman, Millar & Jacobson, 1977;Guth & Smith, 1978b), rabbit and pig coronary (Coruzzi, Bongrani & Bertaccini, 1979;Hagen & Paegelow, 1980), rabbit renal (Angus & Korner, 1977), rabbit ear (Ercan & Turker, 1975), cat and dog cerebral vasculatures (Edvinsson & Owman, 1975;Toda, 1977;Wahl & Kuschinsky, 1979) and cat and dog blood pressure (Black, Owen & Parsons, 1975) have been described. Some of these authors have postulated from the results of experiments in situ that both H1-and H2-receptors participate in a common response, such as a vasodilatation, an increase in the blood flow and a fall of the blood pressure (Black et al, 1975;Flynn & Owen, 1975;Angus & Korner, 1977;Pawlik etal., 1977;Guth & Smith, 1978a, b;Harvey et al, 1980).…”

Section: Introductionmentioning

confidence: 99%

Different Mechanisms of Action of Histamine in Isolated Arteries of the Dog

Konishi

Toda

Yamamoto

1981

British J Pharmacology

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1 In helically-cut strips of dog coronary, superior mesenteric, right gastro-epiploic and renal arteries contracted with prostaglandin F2X (PGF21), histamine produced a dose-related relaxation, while, in contrast, the amine caused only a contraction of cerebral arterial strips. 2 The contractile response of cerebral arteries to histamine was attenuated by chlorpheniramine (10-6M) but was unaffected by cimetidine (10-5M). Relaxant responses to histamine of coronary and renal arteries were significantly attenuated by treatment with cimetidine and to a similar extent by combined treatment with cimetidine and chlorpheniramine. Chlorpheniramine alone was ineffective. 3 In mesenteric and gastro-epiploic arteries, relaxant responses to histamine were attenuated only slightly by cimetidine. Chlorpheniramine slowed the development of histamine-induced relaxations but did not alter the magnitude of the relaxations. Combined treatment with these Hl-and H2-antagonists attenuated the histamine-induced relaxations to an appreciably greater extent than treatment with cimetidine alone. 4 It may be concluded that the cerebroarterial contraction induced by histamine is mediated through HI-receptors and the relaxations of coronary and renal arteries induced by histamine are mediated through H2-receptors. It appears that Hl-and H2-receptors interact with each other to produce potentiation of histamine-induced relaxations of mesenteric and gastro-epiploic arteries.

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“…In the absence of endothelium, 5HT, 14,15,20) His 21) and ACh 22) caused a concentration-dependent contraction of artery preparations including porcine coronary artery. To study the effects of H 2 O 2 and X/XO, we used concentrations of these agonists produced were similar magnitude of high K-induced contraction.…”

Section: Discussionmentioning

confidence: 93%

Differential Inhibition by Oxygen Radicals of Vasoactive Amines-Induced Contractions in the Porcine Coronary Artery

Miyajima

Nakazawa

Muntasir

et al. 2007

Biological & Pharmaceutical Bulletin

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Reactive oxygen species (ROS), such as hydrogen peroxide (H 2 O 2 ), superoxide anion (O 2 ·Ϫ ) and hydroxyl radicals ( · OH) are produced as an byproduct of many cellular reactions including various metabolic and defense processes. 1,2) ROS produced endogenously may contribute cellular damage during ischemia-reperfusion and inflammation. [3][4][5] It has been demonstrated that H 2 O 2 produce contraction in isolated rabbit aorta, 6) canine coronary, 7) rat pulmonary artery 8) and bovine pulmonary artery 9) and relaxation in pig coronary artery.10) Hydroxylradical contract rat aorta. 11) However, there is few reports that their effects on vasoactive amine-induced contractions. For example, Iesaki et al. reported that H 2 O 2 inhibited phenylephrine-induced contraction. 12)Thus, the present study was designed to test the direct effects of H 2 O 2 or ROS generated by exogenous application of xanthine plus xanthine oxidsae (X/XO) on contraction induced by serotonin (5HT), histamine (His) and acetylcholine (ACh) using isolated porcine coronary arteries. Ethylene diamine tetra-acetic acid (EDTA) to chelate metal ions, which promote the production of ROS, and edaravone, a hydroxyl radical scavenger, 13) were used to clarify the participation of · OH.We found that ROS induced different inhibition to 5HT-, His-and ACh-induced contractions of porcine coronary artery. X/XO treatment caused no inhibition of ACh-induced contraction but inhibited 5HT-and His-induced contractions. And some parts of H 2 O 2 action on porcine coronary artery were different from those of ROS derived from X/XO system. MATERIALS AND METHODS SolutionsThe ionic composition of the Krebs-Henseleite (KH) solution used in the present experiment was as follows (mM): NaCl, 118.4; KCl, 4.7; MgSO 4 , 1.2; KH 2 PO 4 , 1.2; NaHCO 3 , 25.0; CaCl 2 , 2.5; and glucose, 11.1. The solution was continuously bubbled with 95% O 2 and 5% CO 2 (pH 7.4). High K ϩ (124 mM) solution was made by isotonic replacement of NaCl with KCl from KH solution.Tissue Preparation and Contraction Experiment Preparation of isolated porcine coronary artery was essentially similar to the methods previously described.14,15) In briefly, porcine hearts were obtained from a local slaughterhouse and transported to the laboratory immersed in ice-cold oxygenated KH solution. The first branch of the left anterior descending coronary artery was dissected and cleaned of all surrounding fat and connective tissue and was cut into rings of 2-3 mm in length. Vascular rings were mounted on two stainless-steel hooks inserted through the lumen of the ring. The bottom hook in each preparation was fixed, whereas the top hook was attached to a force transducer (T7-30-240, Orientec, Japan) mounted on a movable platform, which allowed adjustment of resting tension. Tension changes were recorded on a recorder (Rikadenki Kogyo Co. Ltd., Tokyo, Japan). Each ring was suspended in a 10 ml organ bath and immersed in KH solution maintained at 37°C. The ring was allowed to equilibrate for 60-90 min with an optimal res...

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Histamine H1- and H2-receptors in coronary arteries of pigs

Cited by 25 publications

References 13 publications

Vasomotor effect of histamine on pig and cattle coronary artery in vitro.

Vasomotor effect of histamine on pig and cattle coronary artery in vitro.

Different Mechanisms of Action of Histamine in Isolated Arteries of the Dog

Differential Inhibition by Oxygen Radicals of Vasoactive Amines-Induced Contractions in the Porcine Coronary Artery

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