“…It is involved in several CNS processes including feeding and sleeping regulation, hormonal homeostasis and cognitive functions indeed (Brown et al, 2001; Panula & Nuutinen, 2013; Provensi et al, 2020). All the four histamine receptors (H 1 R‐H 4 R) are expressed in the CNS, but the most explored as drug target to cognitive dysfunctions is the H 3 R, due to its expression as pre‐synaptic auto and hetero‐receptor (Lopes et al, 2021; Nieto‐Alamilla et al, 2016). This means that H 3 R may control the production and release of histamine and other neurotransmitters, being a very attractive target to treat narcolepsy, obesity, ADHD, drug addiction and several other CNS conditions.…”