Histamine, free-histidine concentrations and histidine decarboxylase, histamine methyltransferase activities in developing rat tissues

Fisher, Daniel; Meier, Eileen; Fitzpatrick, Dennis

doi:10.1016/0306-4492(81)90021-6

Cited by 6 publications

(1 citation statement)

References 14 publications

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“…After birth, significant histidine decarboxylase activity in the rat was reported by Aures et al (12) from day 6 to 8, by Ikezaki et al (7) at day 10, and by Fisher et al (27) at day 14. However, because of the large standard errors of the values _reported in the latter study, its finding s cannot be considered conclusive.…”

Section: Discussionmentioning

confidence: 86%

Development of Gastric Histidine Decarboxylase in the Rat

Thiebaut,

Garzon,

Millet

et al. 1985

J. pediatr. gastroenterol. nutr.

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Gastric mucosal histidine decarboxylase (HDase) was measured in fetal rats between days 16 and 21 of gestation, and in newborn rats up to weaning. HDase was not detected in fetal stomach. Its activity developed from day 1 after birth (29 ± 2 pmol CO2/mg protein/h) and increased up to day 18 when it reached the fed adult level (894 ± 170 pmol C O2/mg protein/h). Weaning increased HDase activity significantly (weaned versus un‐weanedrats: 1,664 ± 150 and 1,036 ± 170 pmol C O2/mg protein/h; p < 0.005). Up to day 18, HDase activity was not altered by 16 h to 24 h of fasting. From that day on, HDase became sensitive to both pentagastrin and carbachol. These results indicate that complete functional maturation of histamine‐producing cells is only reached at day 18, just before weaning. This developmental pattern may explain the differences observed between fetal and adult regulation of gastric acid secretion.

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Section: Discussionmentioning

confidence: 86%

Development of Gastric Histidine Decarboxylase in the Rat

Thiebaut,

Garzon,

Millet

et al. 1985

J. pediatr. gastroenterol. nutr.

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Partial characterization of histidine decarboxylase in hamster and rat brain employing a new method

Hegstrand

1985

Neurochem Res

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Histidine decarboxylase activity in hamster and rat brains were studied using a newly developed sensitive, direct radioenzymatic microassay. For our assay conditions, we determined a Km for L-histidine of 320 microM and a Vmax for histidine decarboxylase of 110 pmol histamine/hr/mg protein in rat hypothalamus. The regional distributions of both histidine decarboxylase and histamine levels were similar in the hamster and rat with the most activity in hypothalamus. Most of the histidine decarboxylase activity in rat hypothalamus was in the cytosol fraction. The developmental pattern of histidine decarboxylase in the fetal rat did not reveal a prenatal spike in activity. Histidine decarboxylase activity in rat brain reached adult levels by four weeks. Alpha-fluoromethylhistidine inhibited histidine decarboxylase activity almost totally in vitro at 10 microM and about 80% in vivo after six days of infusion (100 mg/kg/day) in all brain regions except the cerebellum. Likewise, histamine levels were depleted about 75% in all brain regions except the cerebellum.

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Determination of histidine decarboxylase mRNA in various rat tissues by the polymerase chain reaction

et al. 1995

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Histidine decarboxylase (HDC) mRNA in various rat tissues were quantitated by using a reverse transcription-polymerase chain reaction (RT-PCR) in which a mouse mRNA was used as an internal standard. The stomach HDC mRNA level was the highest followed by the brain, skin, jejunum, spleen and liver. There was no measurable HDC mRNA in the kidney. The stomach HDC activity was also the highest followed by the brain, skin, spleen, jejunum, liver and kidney. A significant correlation (r = 0.940, p < 0.0001) was observed between the HDC mRNA levels and HDC activities in these tissues. We have also examined the HDC mRNA levels in fasting rats and found that HDC mRNA levels in the stomach were reduced after the 48-hr-fasting with the decrease in HDC activities. These observations indicate that there may exist a gene regulation, at least at the basal level, for the HDC activities in the rats.

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Histamine, free-histidine concentrations and histidine decarboxylase, histamine methyltransferase activities in developing rat tissues

Cited by 6 publications

References 14 publications

Development of Gastric Histidine Decarboxylase in the Rat

Development of Gastric Histidine Decarboxylase in the Rat

Partial characterization of histidine decarboxylase in hamster and rat brain employing a new method

Determination of histidine decarboxylase mRNA in various rat tissues by the polymerase chain reaction

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