Histamine–cytokine connection in immunity and hematopoiesis

The role of histamine in human mammary carcinogenesis: H3 and H4 receptors as potential therapeutic targets for breast cancer treatment.

“…[10][11][12][23][24][25][26][27][28][29] In the present study, we showed that both H3R and H4R are expressed in human mammary lesions. In agreement with this, we have recently reported that H3R and H4R are expressed, at the protein and mRNA level, by cell lines derived from normal and transformed human mammary gland.…”

“…[10][11][12]26,28,29,39 In the present study, we showed that histamine promotes migration of breast cancer cells and this effect was mimicked by Imetit while was inhibited by Clobenpropit, suggesting that histamine could stimulate breast cancer cell migration via H3R, playing an important role in invasion and metastasis of malignant tumors. In accordance to this, we have recently described that histamine induces migration while it decreases adhesion of PANC-1 pancreatic carcinoma cells.…”

“…The compounds used to address the H3R role in proliferation also bind to the H4R, therefore, despite they present a different rank order of affinity and potency, they do not allow the complete discrimination of the two receptors. [10][11][12]26,28,29,39 To allow the dissection of H3R and H4R signaling, a specific H3R antagonist, JNJ5207852, was used. 26 JNJ5207852 treatment blocked the proliferation increase triggered by 0.01 mM histamine, Imetit and Rα-MeH.…”

“…Histamine exerts its functions through binding to G-protein-associated histamine H1, H2, H3, H4 receptors (H1R, H2R, H3R, H4R), resulting in activation of different signal transduction pathways. [9][10][11][12] High histamine biosynthesis and content has been reported in different human neoplasias including breast cancer, as well as in experimental tumors induced in rodents. 5,[13][14][15] We have previously reported that H1R and H2R are present in different normal and malignant cell lines and benign lesions and tumors derived from human mammary gland.…”

“…[23][24][25][26][27] On the other hand, H4R is predominantly expressed in bone marrow, eosinophils and mast cells. [10][11][12]28,29 Recently, we have demonstrated that H3R and H4R are expressed in cell lines derived from human mammary gland. In addition, histamine is capable of modulating cell proliferation exclusively in malignant cells while no effect is observed in non-tumorigenic cells.…”