Histamine as a Neuroregulator

Prell, George D.; Green, J P

doi:10.1146/annurev.ne.09.030186.001233

Cited by 263 publications

(47 citation statements)

References 91 publications

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“…Histamine H1 receptors are regarded to be coupled to phospholipase C, which catalyzes the formation of Ins(1,4,5)P3 and diacylglycerol (14). We have confirmed this coupling of H1 receptors in type-2 astrocytes by demonstrating that histamine induces Ins (1,4,5 (9,10).…”

supporting

confidence: 67%

“…Recently, type-2 astrocytes have been shown to express glutamate receptors (11,12), suggesting that they are also involved in cell-to-cell communication in the central nervous system. Histamine acts as one of the signal messengers released from neurons (13)(14)(15), and previous studies have shown that mixed cultures of type-2 and type-1 astrocytes express histamine H1 receptors (16, 17), activation of which produces Ins(1,4,5)P3 (14). In the present study, we examined the effects of histamine on [Ca2+], of type-2 astrocytes by fura-2-based digital imaging fluorescence microscopy (4,5 (18,19), as reported previously (20).…”

mentioning

confidence: 99%

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Single type-2 astrocytes show multiple independent sites of Ca2+ signaling in response to histamine.

Inagaki

Fukui

Ito

et al. 1991

Proc. Natl. Acad. Sci. U.S.A.

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MATERIALS AND METHODSPreparation of Cell Cultures. Primary cultures of type-2 astrocytes were prepared from the cerebrum, where dense histaminergic fibers distribute in the brain (18,19), as reported previously (20). Newborn Wistar rats were killed by decapitation. The cerebral hemispheres were collected in Joklik's modified minimum essential medium (MEM) under sterile conditions and the meninges were carefully removed using an operation microscope. The cerebral hemispheres were triturated mechanically with a pipette and then dissociated enzymatically with dispase (neutral protease, dispase grade II) solution (3 mg/ml) in Joklik's modified MEM as reported (17). The dissociated cells in the culture medium (Eagle's MEM containing 10% fetal calf serum, 100.units of penicillin G per ml, and 60 ,ug of kanamycin per ml) were seeded in culture flasks (75 cm2) at a density of 1 x i0' cells per cm2. The cultures were incubated at 37°C in a humid atmosphere of95% air/5% C02; the medium was changed the next day and twice a week thereafter. After 2 weeks in vitro, the small process-bearing 0-2A progenitor cells (21) grown on the top of the type-i astrocyte monolayer were removed mechanically by shaking the culture flasks overnight, seeded onto glass coverslips attached to silicon walls (Heraeus Flexiperm Disc), and subcultured in the same medium containing fetal calf serum for differentiation into type-2 astrocytes (21, 22). After 7 days, >70% of the cultured cells exhibited the characteristics of type-2 astrocytes-i.e., they were stellate cells immunoreactive to antiglial fibrillary acid protein (GFAP) and A2B5 (23) 4215The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.

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supporting

confidence: 67%

mentioning

confidence: 99%

Single type-2 astrocytes show multiple independent sites of Ca2+ signaling in response to histamine.

Inagaki

Fukui

Ito

et al. 1991

Proc. Natl. Acad. Sci. U.S.A.

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“…Our evidence is consistent with the conclusion that the HA receptor is a ligand-gated channel similar to a nicotinic acetylcholine receptor or a GABAA receptor. This finding is in direct contrast to HA effects mediated by second messengers in molluscan neurons (5,6) and to biochemical evidence from mammalian brain linking HA receptors to second messengers (2,3,(7)(8)(9). Many of the properties of the HA receptor-chloride permeability, voltage dependence, bursting behavior, ohmic behavior, and conductances-are similar to those of the GABAA and glycine receptors (23)(24)(25)(26)(27).…”

Section: Discussionmentioning

confidence: 76%

“…Histamine (HA) is a putative neurotransmitter and important neuroregulatory compound in diverse species (1)(2)(3)(4). The intracellular effector mechanisms mediating HA responses investigated to date involve biochemical second messengers (5)(6)(7)(8)(9).…”

mentioning

confidence: 99%

Histamine directly gates a chloride channel in lobster olfactory receptor neurons.

McClintock

Ache

1989

Proc. Natl. Acad. Sci. U.S.A.

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Biogenic amines mediate many types of intercellular communication in multicellular organisms. Heretofore, little direct evidence has indicated that biogenic amines produce intracellular responses other than by triggering the enzymatic production of second messengers. Our electrophysiological studies of lobster olfactory receptor neurons now reveal that one biogenic amine, histamine, can directly gate an ion channel. The channel responds to histamine concentrations of 1 ,xM or more, is permeable primarily to Cl-, is more active at depolarized potentials, and has a conductance of 44 pS in the American lobster and 66 pS in the Caribbean spiny lobster. The expression of this ligand-gated channel in olfactory receptor neurons implies that these neurons are targets of a regulatory or feedback process.Histamine (HA) is a putative neurotransmitter and important neuroregulatory compound in diverse species (1-4). The intracellular effector mechanisms mediating HA responses investigated to date involve biochemical second messengers (5-9). We recently discovered that application of HA to the somata of spiny lobster olfactory receptor neurons suppresses both spontaneous and odor-evoking spiking in these cells by rapidly activating a Cl-current (10). The rapid time course of this effect, as well as recent evidence that HA mediates fast synaptic transmission in arthropods (11-15) and molluscs (1, 16), raises the possibility that HA can also act by directly gating ion channels. We now provide evidence that lobster olfactory receptor neurons express a chloride channel that is directly gated by HA. Evidence is also provided to support the conclusion that this channel mediates the suppressive action of HA on lobster olfactory receptor neurons. MATERIALS AND METHODSAnimals. Adult specimens of the Caribbean spiny lobster Panulirus argus were collected in the Florida Keys and maintained in flowing seawater at 18°C-23°C. Similar specimens of the American lobster Homarus americanus were purchased from commercial suppliers in Woods Hole, MA, and were maintained in flowing seawater at 13°C-17°C.Patch-Clamp Recording. Olfactory receptor neurons were prepared for patch-clamp recording as described (17, 18). Briefly, olfactory organs were cut into hemicylindrical sections, exposing the clusters of receptor neuron somata. Sections from American lobsters were treated with collagenase (1 mg/ml; Sigma, type 1A) for 60 min followed by trypsin(1 mg/ml in Ca2+-free saline; Sigma, type IX) for another 20 min. Sections from spiny lobsters were treated with Lcysteine-activated papain (0.25 mg/ml; Sigma, type IV) for 20 min and then with trypsin for another 20 min. For whole-cell voltage-clamp recording, somata were isolated by drawing clusters of somata into a fire-polished glass pipette and expelling them into a recording dish, a process that severed the dendrite and any remaining axon from these bipolar neurons. Voltage-clamp and single-channel recording were performed by conventional patch-clamp methods with commercially available electron...

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“…The role of HA in the mammalian brain is well established (Haas, 1985 ;Prell & Green, 1986 ;Panula, 1987 ;Schwartz et al ., 1991 ;Yamatodani et al, 1991), and both electrophysiology (McCaman & Weinreich, 1985) and immunocytochemistry (Soinila et al ., 1990 ;Elste et al ., 1990) have indicated that HA is a neurotransmitter in the marine mollusc Aplysia . In the insect eye, HA functions as a photoreceptor cell transmitter (Hardie, 1987 ;Pirvola et al, 1988 ;Nassel et al ., 1988) .…”

Section: Introductionmentioning

confidence: 99%

An immunocytochemical method for histamine: application to the planarians

et al. 1995

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Histamine-immunoreactivity was investigated in the planarians Dugesia tigrina and Polycelis nigra . Specific antisera against a histamine-protein conjugate were used, and 1-ethyl-3 (3-dimethyl-aminopropyl) carbodiimide was used both as coupling agent to prepare the antigen and as a tissue fixative . In D. tigrina, histamine-immunoreactivity was restricted to photoreceptor cells in the cerebral eye . In P nigra, nerve fibers were found in the ventral nerve cord and nerves running laterally from these . The epidermal eyes did not display histamine-immunoreactivity . The results suggest that histamine may be a transmitter in some of the most primitive animals. They also suggest that the distribution of histamine may differ in planarians .

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Histamine as a Neuroregulator

Cited by 263 publications

References 91 publications

Single type-2 astrocytes show multiple independent sites of Ca2+ signaling in response to histamine.

Single type-2 astrocytes show multiple independent sites of Ca2+ signaling in response to histamine.

Histamine directly gates a chloride channel in lobster olfactory receptor neurons.

An immunocytochemical method for histamine: application to the planarians

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