“…26,[36][37][38] However, neither levocetirizine nor desloratadine had any effect on the expected postallergen challenge tryptase release (Fig 3, B). 13,39,40 Accordingly, most studies could not demonstrate any inhibitory effect of antihistamines on tryptase increase in nasal lavage fluid, even after a 7-day pretreatment. 26,36 However, a limitation of tryptase secretion was suggested by Jacobi et al 41 after pretreatment for 7 days with topical azelastine (0.14 mg twice daily in each nostril) and cetirizine (10 mg daily).…”