Histamine and Serotonin

Barnes, Peter J.

doi:10.1006/pupt.2000.0318

Cited by 62 publications

(41 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although serotonin does not constrict the human airway smooth muscle in vitro, it increases acetylcholine release from airway nerves via 5HT3 and 5HT4 receptors. 35 The activation of the serotoninergic receptors on human airway epithelial cells regulates the release of IL-6 and IL-8. 36 SLC6A4 could play a role in the inflammatory responses of human airway epithelial cells in COPD subjects by changing the concentration of serotonin in the peripheral lungs.…”

Section: Discussionmentioning

confidence: 99%

Association of serotonin transporter gene variation with smoking, chronic obstructive pulmonary disease, and its depressive symptoms

et al. 2010

View full text Add to dashboard Cite

A serotonin transporter gene, SLC6A4, is thought to be related to nicotine dependence and depression, one of the comorbidities of chronic obstructive pulmonary disease (COPD). To investigate the association between SLC6A4 variation and tobacco consumption, susceptibility to COPD, and depression status. In all, 247 patients with COPD and 119 control subjects were genotyped for 5 tag single-nucleotide polymorphisms (SNPs) of SLC6A4. We analyzed the correlation between these genotypes and COPD, using the results of a pulmonary function test or chest computed tomography; data on tobacco consumption (packyears); and the depression score based on the hospital anxiety and depression scale (HADS) after adjusting for age, gender, and smoking status (and pack-years, when appropriate). The rare allele rs2020936 was significantly associated with COPD incidence in the trend model (P¼0.003; odds ratio, 2.20; 95% confidence interval, 1.31-3.74). This allele was also associated with the number of pack-years (P¼0.026). The major allele of another SNP of SLC6A4, namely rs3794808, correlated with the HADS depression score (P¼0.016). We conclude that SLC6A4 variation affects COPD pathogenesis, and this effect depends partly on tobacco consumption. SLC6A4 variation also affects depressive symptoms. SLC6A4 could be modified to prevent COPD and treat the depressive symptoms of COPD.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of serotonin transporter gene variation with smoking, chronic obstructive pulmonary disease, and its depressive symptoms

et al. 2010

View full text Add to dashboard Cite

show abstract

“…In fact, our data suggest that the induction of pulmonary IDO by antigen-specific Th1 cell lines negatively controls their own survival and their inflammatory response, i.e., M-trp implantation reduced Th1 cell death ( Figure 5D) and increased neutrophil infiltration, a marker of pulmonary inflammation ( Figure 5C). IDO can inhibit Th-mediated lung inflammation in multiple ways: (a) it depletes trp availability in the microenvironment (22); (b) it promotes the generation of various toxic trp metabolites, which induce Th cell death (30,31); (c) it generates other compounds, e.g., formylkynurenine, through a reaction that removes oxygen radicals at inflammatory sites (32); and (d) in the case of Th2-mediated lung inflammation, it inhibits the generation of 5-hydroxytryptamine, a potent airway constrictor (33). These unique and synergistic activities of IDO likely collaborate to inhibit Th2-mediated experimental asthma and to attenuate Th1-mediated pulmonary inflammation.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of experimental asthma by indoleamine 2,3-dioxygenase

Hayashi¹,

Beck²,

Rossetto³

et al. 2004

J. Clin. Invest.

320

207

View full text Add to dashboard Cite

Epidemiological evidence points to the inverse relationship between microbial exposure and the prevalence of allergic asthma and autoimmune diseases in Westernized countries. The molecular basis for this observation has not yet been completely delineated. Here we report that the administration of certain toll-like receptor (TLR) ligands, via the activation of innate immunity, induces high levels of indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme of tryptophan catabolism in various organs. TLR9 ligand-induced pulmonary IDO activity inhibits Th2-driven experimental asthma. IDO activity expressed by resident lung cells rather than by pulmonary DCs suppressed lung inflammation and airway hyperreactivity. Our results provide a mechanistic insight into the various formulations of the hygiene hypothesis and underscore the notion that activation of innate immunity can inhibit adaptive Th cell responses.

show abstract

“…When considering the role of the eosinophil in AHR, we must understand the mechanisms of AHR and then consider where any single cell type would be positioned to cause such effect. While the smooth muscle layers of asthmatic airways can become hypertrophied and more fibrous with time, whether the muscle is intrinsically more hyperresponsive to stimulation remains unclear (34).…”

Section: Tissue Localization and Activation Status Of The Eosinophil mentioning

confidence: 99%

The rise of the phoenix: the expanding role of the eosinophil in health and disease

Adamko

Odemuyiwa

Vethanayagam

et al. 2004

Allergy

View full text Add to dashboard Cite

We have entered a new phase in the evolution of our understanding of the role of the eosinophil with a greater appreciation of novel potential functions that may be ascribed to this enigmatic cell type. This review not only provides an update to our current understanding of the various immunobiological roles for the eosinophil, but also attracts attention to some novel observations predicting functions beyond its putative effector role. These observations include the intriguing possibility that the eosinophil may posses the capacity to regulate the immune and inflammatory responses in diseases such as asthma.

show abstract

Histamine and Serotonin

Cited by 62 publications

References 119 publications

Association of serotonin transporter gene variation with smoking, chronic obstructive pulmonary disease, and its depressive symptoms

Association of serotonin transporter gene variation with smoking, chronic obstructive pulmonary disease, and its depressive symptoms

Inhibition of experimental asthma by indoleamine 2,3-dioxygenase

The rise of the phoenix: the expanding role of the eosinophil in health and disease

Contact Info

Product

Resources

About