Histamine and Its Receptors as a Module of the Biogenic Amine Diseasome

López, Rocío Rodríguez; Morales, María; Sánchez‐Jiménez, Francisca

doi:10.1007/978-3-319-40308-3_7

Cited by 2 publications

(2 citation statements)

References 173 publications

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“…It is a well-known immune mediator, as well as a neurotransmitter, thus involved in the most complex and still not fully characterized physiological capabilities. It also plays a key role in gastric acid secretion, and has also been described as a cell proliferation modulator, nutrition and cell proliferation being two essential functions for life [ 13 ].…”

Section: Histamine Biochemistry and Physiologymentioning

confidence: 99%

“…However, evidence has accumulated revealing important roles of these metabolites in mammalian pathophysiology. For instance, it is well known that HIS is an important mediator of the immune system, as well as a key biomolecule for correct gastric function [ 13 , 14 , 15 ] ( Table 1 ). Nowadays, we can say that they are very important for human homeostasis, as they play important roles in the most important human physiological functions (neurotransmission, defence, digestion and nutrition, growth, apoptosis, and reproduction).…”

Section: Introductionmentioning

confidence: 99%

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What We Know and What We Need to Know about Aromatic and Cationic Biogenic Amines in the Gastrointestinal Tract

Fernández-Reina

Urdiales

Sánchez‐Jiménez

2018

Foods

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Biogenic amines derived from basic and aromatic amino acids (B/A-BAs), polyamines, histamine, serotonin, and catecholamines are a group of molecules playing essential roles in many relevant physiological processes, including cell proliferation, immune response, nutrition and reproduction. All these physiological effects involve a variety of tissue-specific cellular receptors and signalling pathways, which conforms to a very complex network that is not yet well-characterized. Strong evidence has proved the importance of this group of molecules in the gastrointestinal context, also playing roles in several pathologies. This work is based on the hypothesis that integration of biomedical information helps to reach new translational actions. Thus, the major aim of this work is to combine scientific knowledge on biomolecules, metabolism and physiology of the main B/A-BAs involved in the pathophysiology of the gastrointestinal tract, in order to point out important gaps in information and other facts deserving further research efforts in order to connect molecular information with pathophysiological observations.

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Section: Histamine Biochemistry and Physiologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

What We Know and What We Need to Know about Aromatic and Cationic Biogenic Amines in the Gastrointestinal Tract

Fernández-Reina

Urdiales

Sánchez‐Jiménez

2018

Foods

Self Cite

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Exploring the Sublethal Impacts of Cu and Zn on Daphnia magna: a transcriptomic perspective

Paylar,

Bezabhe,

Jass

et al. 2024

BMC Genomics

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Metal contamination of aquatic environments remains a major concern due to their persistence. The water flea Daphnia magna is an important model species for metal toxicity studies and water quality assessment. However, most research has focused on physiological endpoints such as mortality, growth, and reproduction in laboratory settings, as well as neglected toxicogenomic responses. Copper (Cu) and zinc (Zn) are essential trace elements that play crucial roles in many biological processes, including iron metabolism, connective tissue formation, neurotransmitter synthesis, DNA synthesis, and immune function. Excess amounts of these metals result in deviations from homeostasis and may induce toxic responses. In this study, we analyzed Daphnia magna transcriptomic responses to IC5 levels of Cu (120 µg/L) and Zn (300 µg/L) in environmental water obtained from a pristine lake with adjusted water hardness (150 mg/L CaCO3). The study was carried out to gain insights into the Cu and Zn regulated stress response mechanisms in Daphnia magna at transcriptome level. A total of 2,688 and 3,080 genes were found to be differentially expressed (DEG) between the control and Cu and the control and Zn, respectively. There were 1,793 differentially expressed genes in common for both Cu and Zn, whereas the number of unique DEGs for Cu and Zn were 895 and 1,287, respectively. Gene ontology and KEGG pathways enrichment were carried out to identify the molecular functions and biological processes affected by metal exposures. In addition to well-known biomarkers, novel targets for metal toxicity screening at the genomic level were identified.

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Histamine and Its Receptors as a Module of the Biogenic Amine Diseasome

Cited by 2 publications

References 173 publications

What We Know and What We Need to Know about Aromatic and Cationic Biogenic Amines in the Gastrointestinal Tract

What We Know and What We Need to Know about Aromatic and Cationic Biogenic Amines in the Gastrointestinal Tract

Exploring the Sublethal Impacts of Cu and Zn on Daphnia magna: a transcriptomic perspective

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