Histamine and its metabolism in mammals part I: Chemistry and formation of histamine

Maśliński, Cz.

doi:10.1007/bf02027348

Cited by 33 publications

(18 citation statements)

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“…28 To directly show the effect of BCR/ABL on expression of HDC mRNA and synthesis of histamine, Ba/F3 cells with doxycyclineinducible expression of BCR/ABL (Ton.B210 and Ton.B210-X cells) 38 were used. Using these cells, we were able to show that BCR/ABL induces the expression of HDC and the synthesis of histamine.…”

Section: Discussionmentioning

confidence: 99%

“…[24][25][26][27] The key enzyme involved in histamine generation is histidine decarboxylase (HDC). 28 This enzyme is expressed in basophilcommitted progenitors as well as in mature basophils. 21,23 Interleukin-3 (IL-3), a major differentiation factor for basophils, has been reported to induce the expression of HDC and thus synthesis of histamine in myeloid progenitors.…”

Section: Introductionmentioning

confidence: 99%

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The CML-related oncoprotein BCR/ABL induces expression of histidine decarboxylase (HDC) and the synthesis of histamine in leukemic cells

Aichberger

Mayerhofer

Vales

et al. 2006

Blood

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The CML-related oncoprotein BCR/ABL induces expression of histidine decarboxylase (HDC) and the synthesis of histamine in leukemic cells

Aichberger

Mayerhofer

Vales

et al. 2006

Blood

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“…However, relatively large numbers of mast cells are present in the peritoneum (2-5% of total cells) (23), and peritoneal mast cells may contain 2-10 picograms of histamine per cell (62). On the other hand, MØ only contain small amounts of histamine (about 0.5% of the histamine stored in mast cells) (35,61,63). Therefore, mast FIG.…”

Section: Implanted Biomaterials Trigger the Release Of Histaminementioning

confidence: 99%

Mast cells mediate acute inflammatory responses to implanted biomaterials

Tang

Jennings

Eaton

1998

Proc. Natl. Acad. Sci. U.S.A.

247

185

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Implanted biomaterials trigger acute and chronic inf lammatory responses. The mechanisms involved in such acute inf lammatory responses can be arbitrarily divided into phagocyte transmigration, chemotaxis, and adhesion to implant surfaces. We earlier observed that two chemokinesmacrophage inf lammatory protein 1␣͞monocyte chemoattractant protein 1-and the phagocyte integrin Mac-1 (CD11b͞CD18)͞surface fibrinogen interaction are, respectively, required for phagocyte chemotaxis and adherence to biomaterial surfaces. However, it is still not clear

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“…Methylprednisolone concentration (C MP ) versus time (t) curves after intravenous administration were fitted by a 1-compartment model with 1/y weighting using WinNonlin 4.1 (Pharsight Corp, Mountain View, Calif) according to (1) where D is the dose administered, V d is the volume of distribution, and k el is the first-order elimination rate constant. Half-life (t ½ ) was calculated as 0.693/k el , clearance (CL) as a product of k el and V d , and the area under the concentration versus time curve (AUC) as D/CL.…”

Section: Pharmacokineticsmentioning

confidence: 99%

“…decarboxylase (HDC) 1 and is metabolized by diamine oxidase and histamine Nmethyltransferase (HNMT). 2 Histamine N-methyltransferase catalyzes the N-methylation of histamine, which was suggested to be the major significant pathway for the biotransformation of histamine in bronchial epithelium and the brain.…”

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confidence: 99%

Altered Methylprednisolone Pharmacodynamics in Healthy Subjects With Histamine N‐Methyltransferase C314T Genetic Polymorphism

Hon

Jusko

Spratlin

et al. 2006

The Journal of Clinical Pharma

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This study investigated the potential differences in methylprednisolone pharmacodynamics between healthy subjects with different histamine N-methyltransferase (HNMT) C314T genotypes. Six individuals with C/C genotype and 4 with C/T genotype were administered a single intravenous dose of methylprednisolone 0.6 mg/kg ideal body weight in a randomized 2-period manner. Methylprednisolone plasma concentrations were fitted with a 1-compartment model. Cortisol and whole blood histamine suppression were assessed by indirect response models, with circadian baseline cortisol analyzed by Fourier analysis. The area between the baseline and effect curve and the area under the effect versus time curve suppression ratiowere used to characterize plasma histamine suppression. Methylprednisolone pharmacokinetics and plasma and whole blood histamine suppression were similar between the 2 genotype groups. Median nadir of cortisol and the 50% inhibitory concentration for cortisol were significantly higher in subjects with C/T genotype than those with C/C genotype (P = .031 and .033, respectively, Wilcoxon rank sum test). Subjects who are heterozygous for the T314 variant allele thus appeared less sensitive to the suppressive effects of methylprednisolone on cortisol secretion. KeywordsCorticosteroids; methylprednisolone pharmacodynamics; cortisol suppression; histamine suppression; HNMT polymorphism Histamine is an important mediator in the body that is involved in the regulation of numerous physiologic and pathophysiologic processes including gastric acid secretion, central nervous system functioning, bronchial asthma, and hypersensitivity reactions. It is formed by decarboxylation of histidine, a metabolic pathway that is catalyzed by histidine NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript decarboxylase (HDC) 1 and is metabolized by diamine oxidase and histamine Nmethyltransferase (HNMT). 2 Histamine N-methyltransferase catalyzes the N-methylation of histamine, which was suggested to be the major significant pathway for the biotransformation of histamine in bronchial epithelium and the brain. [3][4][5] Interindividual variation of HNMT activity has been demonstrated in whites and Han Chinese. 6,7 This variability can be explained in part by a C to T transition at nucleotide 314 (exon 4) of the HNMT gene, causing an amino acid change of threonine to isoleucine at codon 115, which results in low immunoreactive HNMT protein and activity. 8 Previously, HNMT activity in red blood cell lysate was found to be lower in persons who are heterozygous for the T314 allele than in those with homozygous wild-type genotype. 7,8 Corticosteroids are widely used for their anti-inflammatory and immunosuppressive effects in various diseases including allergic diseases such as asthma, urticaria, rhinitis, and anaphylaxis. These agents elicit a number of pharmacodynamic responses including suppression of cortisol secretion, cell trafficking, and whole blood histamine (WBH) concentrations. The suppressive effects of c...

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Histamine and its metabolism in mammals part I: Chemistry and formation of histamine

Cited by 33 publications

References 0 publications

The CML-related oncoprotein BCR/ABL induces expression of histidine decarboxylase (HDC) and the synthesis of histamine in leukemic cells

The CML-related oncoprotein BCR/ABL induces expression of histidine decarboxylase (HDC) and the synthesis of histamine in leukemic cells

Mast cells mediate acute inflammatory responses to implanted biomaterials

Altered Methylprednisolone Pharmacodynamics in Healthy Subjects With Histamine N‐Methyltransferase C314T Genetic Polymorphism

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