Histamine and GABA

Nafi, M.M.; Menassa, Pierre; Sándorfy, C.

doi:10.1016/0301-4622(87)80091-1

Cited by 1 publication

(1 citation statement)

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“…As mentioned above, histamine and GABA are two main neurotransmitters that can stimulate a similar ion channel (Saras et al ., 2008). Though the mechanism of their function is not understood in all its details, it is now broadly known that the main step in this mechanism participates in an interaction between the neurotransmitter and a biological membrane (Nafi et al ., 1987). Reports are displaying the existence of a functional interaction between the GABAergic and histaminergic systems in the brain (Hajizadeh Moghaddam et al ., 2008).…”

Section: Discussionmentioning

confidence: 99%

Additive effect of histamine and muscimol upon induction of antinociceptive and antidepressant effects in mice

Baghani

Fathalizade

Khakpai

et al. 2023

Behavioural Pharmacology

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We investigated the effects of histamine and GABAA receptor agents on pain and depression-like behaviors and their interaction using a tail-flick test and the forced swimming test (FST) in male mice. Our data revealed that intraperitoneal administration of muscimol (0.12 and 0.25 mg/kg) increased the percentage of maximum possible effect (%MPE) and area under the curve (AUC) of %MPE, indicating an antinociceptive response. Intraperitoneal injection of bicuculline (0.5 and 1 mg/kg) decreased %MPE and AUC of %MPE, suggesting hyperalgesia. Moreover, muscimol by reducing the immobility time of the FST elicited an antidepressant-like response but bicuculline by enhancing the immobility time of the FST caused a depressant-like response. Intracerebroventricular (i.c.v.) microinjection of histamine (5 µg/mouse) enhanced %MPE and AUC of %MPE. i.c.v. infusion of histamine (2.5 and 5 µg/mouse) decreased immobility time in the FST. Co-administration of different doses of histamine along with a sub-threshold dose of muscimol potentiated antinociceptive and antidepressant-like responses produced by histamine. Cotreatment of different doses of histamine plus a noneffective dose of bicuculline reversed antinociception and antidepressant-like effects elicited by histamine. Cotreatment of histamine, muscimol, and bicuculline reversed antinociceptive and antidepressant-like behaviors induced by the drugs. The results demonstrated additive antinociceptive and antidepressant-like effects between histamine and muscimol in mice. In conclusion, our results indicated an interaction between the histaminergic and GABAergic systems in the modulation of pain and depression-like behaviors.

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Section: Discussionmentioning

confidence: 99%