Histamine and antihistamine in anaesthesia and surgery

Thornton, J. A.; Lorenz, W.

doi:10.1111/j.1365-2044.1983.tb10463.x

Cited by 19 publications

(1 citation statement)

References 42 publications

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“…In the present investigation, we have adopted a third method in evaluating the histamine releasing effect of atracurium, vecuronium and gallamine, by using a pharmacologic technique, i.e. Since atracurium and other muscle relaxants contract the smooth muscle of the rat ileum [16], it was desired to know to what extent this contraction was reduced by antihistamines (also see [15,17,18]), e.g. However, one problem is that the rat mast cell contains 5-HT as well as histamine, and it is not possible to differentially separate the two components, in this study, (also see [14,15]), by the use of antihistamines alone.…”

Section: Introductionmentioning

confidence: 99%

A pharmacologic study on the histamine releasing effect of atracurium and other muscle relaxants in rat isolated ileum

et al. 1987

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In this study, the effects of histamine, antihistamines (terfenadine and mepyramine), 5-hydroxytryptamine, and muscle relaxants, atracurium, vecuronium and gallamine, on the tone and contractility of rat ileum were studied and compared in vitro. The aim of the present investigation was to measure, pharmacologically, the histamine releasing effect of muscle relaxants, e.g atracurium, vecuronium and gallamine, by comparing their contractile response in the absence and presence of antihistamines and comparing their mechanical responses with those produced by histamine and 5-hydroxytryptamine (5-HT). The results showed that the antihistamines, triludan(terfenadine) and mepyramine produced opposite effects in rat ileum. Terfenadine (0.1-20 microM) produced concentration-dependent contractions in the rat ileum, whereas mepyramine (0.1-10 microM) relaxed the muscle, e.g. by 1.2 g tension. Atracurium (0.5-500 microM), vecuronium (0.2-200 microM), and gallamine (0.1-7.0 microM) produced marked contractions (1.5-4.0 g tension) in rat ileum, and these contractions were markedly reduced by mepyramine (1.3 microM) or terfenadine (5 microM), implicating histamine release in the generation of these contractions. However, there was some residual contraction which was not blocked by mepyramine, but by 5-HT antagonist, methysergide (1 microM), indicating that a mechanism other than histamine release may be responsible for the residual contraction, i.e. release of other mediators such as 5-HT, prostaglandins, or calcium. 5-HT (0.5-500 microM) and histamine (0.5-500 microM) produced contractions in the rat ileum, but 5-HT was more effective than histamine in producing these contractions. Similarly, gall amine was more effective than atracurium and vecuronium in contracting the rat ileum.(ABSTRACT TRUNCATED AT 250 WORDS)

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