Histamine and Anaphylaxis

Preparations of Purified Antigens from Staphylococcus Aureus in Biologic and Serologic Experiments

“…The lesions were 10 xlO mm to 20 x!5 mm and of the same gross appearance as those produced by epinephrine in twelve other animals into which E. coli endotoxin had been injected intravenously. Four of these had received 50 ¡ig of endotoxin; the remaining eight 10 /xg of the toxin. The resulting haemorrhagic areas were round or oval and deep blue, typical for 24 h lesions in this test (33).…”

“…From J ensen's reports it is not clear whether he had systematically investigated guinea-pig sera for anti-protein A, but one serum was described as void of this antibody. If so, anaphylaxis to protein A might not be the only mechanism involved.-An ex tended study of these problems has been started to explain pharma cologically the observed activity of fraction A-l on isolated guineapig ileum and the relation of the mode of action to production and release of pharmacologically active amines and/or other substances in anaphylaxis (10,12,13,17).…”

A New General Concept of the Neurohumoral Functions of Acetylcholine and Acetylcholinesterase

“…Recently, R. L. Volle and I (1961) undertook an investigation of the primary role of the AChE of the cat superior cervical ganglion. Four possibilities were suggested from the earlier literature : (I) temporal and spatial limitation of the transmitter action of ACh at the postsynaptic site (Feldberg and Vartiainan, 1934 ;Eccles, 1944 ;Holaday and others, 1954), (2) provision of an immediate source of choline, by the hydrolysis of liberated ACh, for uptake and synthesis of ACh by the preganglionic terminals (Perry, 1953 ;, (3) prevention of the accumulation of sufficient ACh liberated during the resting stage to activate the ganglion cells (Feldberg, 1945a), and (4) protection of the presynaptic terminals against the effects of ACh released during the resting or active stages . Previous reports indicating the first possibility were confirmed by measuring the effects of intraarterially injected diisopropyl phosphorofluoridate (DFP) on the post- ganglionic response to supramaximal stimulation of the partially resected preganglionic trunk.…”

Biochemical Mechanism of the Allergic Reaction

“…Lewis, Krogh and Ebbecke, was proved experimentally by Bartosch, Feldberg and Nagel (4), Dragsledt and Mead (23), Ungar and Parrot (94) and others. The development of the theory was described in the reviews of Dragstedt (22), Feldberg (27) and Ungar (79).…”