Histamine and allergen induced changes in nasal airways resistance measured by anterior rhinomanometry: reproducibility of the technique and the effect of topically administered antihistaminic and anti‐ allergic drugs.

Abstract

EC11 Changes in nasal airways resistance (NAR) following the topical application of histamine and allergen solutions were measured by passive anterior rhinomanometry. 2 The repeatability of five consecutive measurements of resting NAR prior to provocation with histamine or allergen (expressed as the coefficient of variation) was 32.8% and following instillation of saline control solution 37.2%. 3 The repeatability of five consecutive measurements of NAR during the nasal obstruction produced by histamine and allergen was similar to that recorded prior to provocation; the coefficients of variation (median values) being 39.6% and 33.1% respectively. The degree of variability was not related to the dose of agonist or the degree of nasal obstruction. 4 The reproducibility of histamine or allergen induced changes in NAR on four separate weekly occasions showed no significant intra-subject differences. 5 The effects of sodium cromoglycate (SCG), clemastine and ketotifen administered to the nasal mucosa 30 min before provocation with histamine and allergen were compared in a random order, double-blind, placebo controlled study. 6 Clemastine and SCG, but not ketotifen, significantly inhibited the nasal response to increasing concentrations of histamine. None of the drugs administered in the concentrations used in this study significantly inhibited the nasal response to allergen.

Acoustic rhinometry compared with posterior rhinomanometry in the measurement of histamine‐ and bradykinin‐induced changes in nasal airway patency.

“…Furthermore, measurements made by acoustic rhinometry have been compared with those made by the established method of posterior rhinomanometry. Histamine and bradykinin were chosen for this comparative study because the effects of histamine on the nasal airway are well established [8,9], as are those of bradykinin [10,11]. Histamine-and bradykinin-induced changes in NAR are in agreement with previously established effects of these agents.…”

Physiologic assessment of allergic rhinitis in mice: Role of the high-affinity IgE receptor (FcɛRI)

“…2 The typical symptoms of AR in human subjects are well known, mainly sneezing and nasal blockage. 3,4 The 3 major causes of the nasal blockage are thought to be dilitation of capacitance vessels in the nasal septum and turbinates, edematous swelling of nasal membranes, and the direct result of secretions. [5][6][7][8] The mechanisms underlying the development of bronchial asthma have been analyzed, measuring lower airway function.…”

Time Course of Cellular Infiltration in the Nasal Mucosa during the Immediate Allergic Reaction

“…P.K. Morgan, Gillingham, UK) [6], Subjects were rested for 15 min before making measurements and a minimum of five readings were taken from each nostril at each time point. The mean of these five readings was taken as the value of NAR for the respec tive nostril.…”