Hispidulin: a promising anticancer agent and mechanistic breakthrough for targeted cancer therapy

Chaudhry, Gul-e-Saba; Zeenia,; Sharifi-Rad, Javad; Calina, Daniela

doi:10.1007/s00210-023-02645-9

Cited by 3 publications

(2 citation statements)

References 99 publications

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“…Limonin was significantly upregulated in WG and serves as an activator of AMP-activated protein kinase with anti-inflammatory and antioxidant effects ( Liang et al, 2023 ). Hispidulin, a promising anticancer agent ( Chaudhry et al, 2023 ), was significantly upregulated in AY38 and could be considered a characteristic metabolite of this cultivar. The above is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Integrated HS-GC–IMS and UPLC-Q-Orbitrap HRMS-based metabolomics revealed the characteristics and differential volatile and nonvolatile metabolites of different citrus peels

Wang,

Wang

et al. 2024

Current Research in Food Science

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Section: Resultsmentioning

confidence: 99%

Integrated HS-GC–IMS and UPLC-Q-Orbitrap HRMS-based metabolomics revealed the characteristics and differential volatile and nonvolatile metabolites of different citrus peels

Wang,

Wang

et al. 2024

Current Research in Food Science

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“…It is predominantly found in plants belonging to the Asteraceae [131][132][133] and Lamiaceae families [134] . According to research, hispidulin has various biological effects, including those that are anti-inflammatory, antifungal, antiplatelet, anticonvulsant, anti-osteoporotic, and most significantly, anticancer [135,136] .…”

Section: Hispidulinmentioning

confidence: 99%

Comprehensive Review on Mechanistic Insights, Optimal Dosages, and Safety Prospective of Natural Products in Anticancer Therapeutics

Chaudhry,

Zeenia,

Akim

et al. 2024

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Cancer remains a formidable global health challenge, necessitating sustained research efforts to develop innovative and efficacious therapeutic modalities. The exploration of alternative cancer therapies has gained prominence, given the adverse side effects associated with conventional treatments like chemotherapy. Natural medicines, particularly those derived from botanical sources, emerge as a potentially more viable option for cancer treatment within the confines of therapeutic and safe dosage parameters. This comprehensive review elucidates the effective mechanisms and safety profiles related to the dosage of these natural compounds. The literature under consideration spans and has been meticulously curated from reputable databases, including PubMed, Scopus, and Google Scholar. Noteworthy natural substances encompassed in this scrutiny include gossypol, curcumin, resveratrol, genistein, anthocyanin, and hispidulin. The review outlines their respective mechanisms, therapeutic dosages, and safety perspectives within the context of cancer treatment. These compounds manifest diverse anticancer effects, ranging from the induction of apoptosis and inhibition of cell proliferation to the modulation of crucial signaling pathways. These natural compounds exhibit promising anticancer potential by targeting key facets of cancer progression, notably by i) instigating apoptosis and ii) intervening in cell cycle checkpoints. However, a more strategic and nuanced investigation is imperative to fully elucidate their optimal dosages, modes of action, and potential synergies with existing cancer treatment modalities. This critical gap in our understanding underscores the necessity for further in-depth research to optimize the therapeutic potential of these plant-derived chemicals.

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Green and Blue Solutions: Natural Compounds from Plants and Marine Organisms Therapeutic Role in Induction of Cancer Cell Death

Chaudhry,

Zeenia,

Akim

et al. 2024

Interdisciplinary Cancer Research

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Hispidulin: a promising anticancer agent and mechanistic breakthrough for targeted cancer therapy

Cited by 3 publications

References 99 publications

Integrated HS-GC–IMS and UPLC-Q-Orbitrap HRMS-based metabolomics revealed the characteristics and differential volatile and nonvolatile metabolites of different citrus peels

Integrated HS-GC–IMS and UPLC-Q-Orbitrap HRMS-based metabolomics revealed the characteristics and differential volatile and nonvolatile metabolites of different citrus peels

Comprehensive Review on Mechanistic Insights, Optimal Dosages, and Safety Prospective of Natural Products in Anticancer Therapeutics

Green and Blue Solutions: Natural Compounds from Plants and Marine Organisms Therapeutic Role in Induction of Cancer Cell Death

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