Hirsutismo en niñas adolescentes: Estudio clínico y de laboratorio

Abstract

Fourteen girls with hirsutisn, aged 12.5 to 16 years, were prospective!-/ studied. Patients with adrenal tumors, pnmary ovary disease or classical congenital adrenal hyperplasia were excluded from this study. Hirsutism was evaluated by the Ferriman score. All patients had normal weight and blood pressure. Urinary 17 hydroxicorticosteroids, pregnanetriol and dehydroepiandrosterone were measured in 24 hour urine samples. Lh, FSH, cortisoi, 1 7-hidroxyprogesterone (17-OhP), dehydroepiandrosterone sulfate (DHEAS) and testosterone in plasms were also measured Defore and 60 min after .ntravenous injection of rapidly acting ACTH (0.25 mg). Ultrasonography of the ovary was also done to each patient. Two patients were probably heterozygotus for 21-hydroxylase deficiency, nine other girls showed high blood levels of DHtAS (average 8289 ng/ml) but in three cases no apparent cause was detected and they were labeled as idiopatic hirsutism. The two patients with evidence of heterozygosity for 21-hidroxylase deficiency and b patients with high DHEAS improved after dexametasone treatment and normalization of their olood ievels of 1 7-OHP and DHEA-S respectively.