Hippophae rhamnoides reverses decreased CYP2D6 expression in rats with BCG-induced liver injury
Huiqiong Zou,
Peipei Hao,
Yingying Cao
et al.
Abstract:In this study, we investigated the effect of Hippophae rhamnoides L. (HRP) on the activity of CYP2D6 via the CAMP/PKA/NF-κB pathway in rats with Bacille Calmette–Guerin (BCG)-induced immunological liver injury. BCG (125 mg/kg) was injected to establish the rat model of liver injury. HRP was administered intragastrically for one week as the intervention drug. Proteomics techniques were used to analyze protein expression levels, obtaining a comprehensive understanding of the liver injury process. ELISA or wester… Show more
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