Hippocampus Volume Loss Due to Chronic Heavy Drinking

Beresford, Thomas P.; Arciniegas, David B.; Alfers, Julie; Clapp, Lori; Martin, Brandon; Du, Yiping P.; Liu, Dengfeng; Shen, Dinggang; Davatzikos, Christos

doi:10.1111/j.1530-0277.2006.00223.x

Cited by 147 publications

(104 citation statements)

References 24 publications

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“…However, we were able to exclude participants with a known history of stroke, a condition that might directly impact brain volumes. Although the findings are somewhat mixed in terms of laterality, studies generally suggest that severe alcohol dependence is associated with reduced hippocampal volume (Beresford et al, 2006;Laakso et al, 2000;Le Berre et al, 2012;Ozsoy et al, 2013). To our knowledge, the degree of reversibility of hippocampal volume changes with alcohol dependence has not been investigated.…”

Section: Discussionmentioning

confidence: 86%

Association of Depressive Symptoms with Hippocampal Volume in 1936 Adults

Brown

Hughes

McColl

et al. 2013

Neuropsychopharmacol

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Hippocampal atrophy is reported in major depressive disorder (MDD). However, sample sizes were generally modest, and participant characteristics, including age, differed between studies. This study used a community sample to examine relationships between current depressive symptom severity and hippocampal volume across the adult lifespan. A total of 1936 adults with magnetic resonance images of the brain and Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR) scores were included. Brain volumes were quantified using the FSL program. Multiple linear regressions were performed using left, right, and total hippocampal volume as criterion variables, and predictor variables of QIDS-SR total, total brain volume, age, gender, education, psychotropic medications, alcohol use, and race/ethnicity. Post hoc analyses were conducted in participants with QIDS-SR scores X11 (moderate or greater depressive symptom severity) and o11, and older and younger adults. In the primary analysis (sample as a whole) QIDS-SR was inversely associated with total hippocampal volume (b ¼ À 0.044, p ¼ 0.032, (CI À 0.019 to À 0.001)) but not with left or right hippocampal volume evaluated individually. In participants with QIDS-SR scores of o11, hippocampal volumes were not associated with QIDS-SR scores. In those with QIDS-SR scores X11 total, right, and left hippocampal volumes were modestly, but significantly, associated with QIDS-SR scores. The association between QIDS-SR scores and the hippocampal volume was much stronger in older persons. Findings suggest smaller hippocampal volumes among those with greater reported depressive symptom severity-an association that is strongest in people with at least moderate depressive symptom levels.

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Section: Discussionmentioning

confidence: 86%

Association of Depressive Symptoms with Hippocampal Volume in 1936 Adults

Brown

Hughes

McColl

et al. 2013

Neuropsychopharmacol

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“…Left amygdala volumetric decrease may account for deficits in performance related to analytical aspects of memory, as well as verbal memory (14,102). Hippocampal and amygdala volume reductions were previously reported in alcoholics (22,55,56), and reduced amygdala volume was present in adolescents of high-risk alcoholism families, indicating a possible neurodevelopmental component (56). However, no prior studies evaluated particular sub-portions of these structures.…”

Section: Topological Analyses In Amygdala and Hippocampusmentioning

confidence: 83%

“…Prior studies have indicated atrophic changes in amygdala and hippocampus in alcoholic subjects (21,22,55,56). Therefore, to further elucidate the sub-regions of these structures potentially impacted by alcoholism, we performed topological analyses using methods described in a previous report (54).…”

Section: Topological Analysesmentioning

confidence: 99%

Decreased Volume of the Brain Reward System in Alcoholism

Makris

Oscar‐Berman

Jaffin

et al. 2008

Biological Psychiatry

343

327

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Background-Reinforcement of behavioral responses involves a complex cerebral circuit engaging specific neuronal networks that are modulated by cortical oversight systems affiliated with emotion, memory, judgment, and decision making (collectively referred to in this study as the "extended reward and oversight system" or "reward-network"). We examined whether rewardnetwork brain volumes are reduced in alcoholics, and how volumes of subcomponents within this system are correlated with memory and drinking-history.

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“…Alcohol use disorders may result in neurocognitive deficits consistent with hippocampal and/or MTL dysfunction (Sullivan et al, 2000;Crews et al, 2005). Previous magnetic resonance studies in one-month-abstinent alcohol dependent individuals demonstrated volume reductions in the bilateral hippocampi (Beresford et al, 2006;Bleich et al, 2003;Sullivan et al, 1995;Agartz et al, 1999;Laakso et al, 2000), with some suggesting differential effects for sex and/or hemisphere (Agartz et al, 1999;Laakso et al, 2000). Small neuropathological studies found unchanged numbers of hippocampal neurons in alcoholics (Korbo, 1999;Harding et al, 1997), but profound loss in glial cell populations (Korbo, 1999) and hippocampal white matter (WM) volume (Harding et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Chronic cigarette smoking modulates injury and short-term recovery of the medial temporal lobe in alcoholics

Gaździński

Durazzo

Yeh

et al. 2008

Psychiatry Research: Neuroimaging

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Memory function is largely mediated by medial temporal lobe (MTL), and its compromise has been observed in alcohol dependence and chronic cigarette smoking. The effects of heavy alcohol consumption and chronic smoking on hippocampal volumes and MTL metabolites and their recovery during abstinence from alcohol have not been assessed. Male alcoholics in treatment (ALC) [13 smokers (sALC) and 11 non-smokers (nsALC)] underwent quantitative magnetic resonance imaging and short-echo proton magnetic resonance spectroscopic imaging at one week and one month of sobriety. Outcome measures were compared to 14 age-matched, non-smoking light-drinkers and were related to visuospatial learning and memory. Over one month of abstinence, N-acetylaspartate, a neuronal marker, and membrane-associated choline-containing metabolites normalized in the MTL of nsALC, but remained low in the MTL of sALC. Metabolite concentration changes in both groups were associated with improvements in visuospatial memory. Hippocampal volumes increased in both groups during abstinence, but increasing volumes correlated with visuospatial memory improvements only in nsALC. In summary, chronic cigarette smoking in alcohol-dependent men appears to have adverse effects on MTL metabolite recovery during short-term sobriety. These data may also have implications for other conditions with established MTL involvement and significant smoking co-morbidity, such as schizophrenia-spectrum and mood disorders.

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Hippocampus Volume Loss Due to Chronic Heavy Drinking

Abstract: These data support the view that heavy drinking exerts a unique and selectively injurious effect on the hippocampus. Further study in larger samples must verify this in a search for possible mechanisms of injury.

Cited by 147 publications

References 24 publications

Association of Depressive Symptoms with Hippocampal Volume in 1936 Adults

Association of Depressive Symptoms with Hippocampal Volume in 1936 Adults

Decreased Volume of the Brain Reward System in Alcoholism

Chronic cigarette smoking modulates injury and short-term recovery of the medial temporal lobe in alcoholics

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