Hippocampus lesions induced deficits in social and spatial recognition in Octodon degus

Uekita, Tomoko; Okanoya, Kazuo

doi:10.1016/j.bbr.2011.01.042

Cited by 47 publications

(30 citation statements)

References 28 publications

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“…Here we report that degus also show recollection of What-Where-Which memory in a task similar to those used by Eacott et al (2005). Previous studies (e.g., Uekita & Okanoya, 2011;Ardiles et al, 2012) have shown that degus preferentially explore novel or unfamiliar objects, as do rats and other rodents. Therefore, we predicted that in the same task as Eacott et al (2005) degus would preferentially re-explore relatively non-habituated objects that were not presented in their holding cage after the first exploration.…”

Section: From When To Which: Alternative Definition In What-where-whementioning

confidence: 57%

“…use: Okanoya, Tokimoto, Kumazawa, Hihara, & Iriki, 2008;Kumazawa-Manita, Hama, Miyawaki, & Iriki, 2013;spatial cognition: Popović, Madrid, Rol, Caballero-Bleda, & Popović, 2010;Uekita & Okanoya, 2011;Kumazawa-Manita et al, 2013). Further studies of various non-social cognitive abilities in degus would be valuable; in view of their role as a model of Alzheimer disease, their memory processes may be especially worthy of attention.…”

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confidence: 99%

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RECOLLECTION OF WHAT-WHERE-WHICH MEMORY IN DEGUS (<i>OCTODON DEGUS</i>)

Betsuyaku

Tsuzuki

Fujita

2016

PSYCHOLOGIA -An International Journal of Psychological Sciences

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To examine if a feature of episodic-like memory reported in rats is shared with other species, we investigated whether degus would form an integrated memory of object (what), place (where), and context (which). We used two E-shaped mazes with different contexts regarding the wall and the floor. Degus were entered into the middle arm and first explored the maze with two trial-unique objects placed at each end of the backbone of the E, with their location reversed between contexts. After being habituated to one of the objects in the holding cage, the degus re-explored the maze. Subjects explored the non-habituated object in these baseline trials. In the critical test, the objects were located at the end of the outer arms of the maze. Degus went into the arm where they expected the non-habituated object significantly more often than the other. This result suggests recollection of an integrated What-WhereWhich memory.

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Section: From When To Which: Alternative Definition In What-where-whementioning

confidence: 57%

mentioning

confidence: 99%

RECOLLECTION OF WHAT-WHERE-WHICH MEMORY IN DEGUS (<i>OCTODON DEGUS</i>)

Betsuyaku

Tsuzuki

Fujita

2016

PSYCHOLOGIA -An International Journal of Psychological Sciences

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“…Most Petrulis and Eichenbaum, 2003;Squires et al, 2006;Feinberg et al, 2012) but not all (Kogan et al, 2000;Uekita and Okanoya, 2011) studies have shown that rodents do not need the hippocampus to recognize conspecifics as familiar. A study in hamsters suggested that so-called recollection memory does require an intact hippocampus: when dorsal CA1 was reversibly inactivated during an encounter with familiar individuals, the subject failed to associate the respective memories (Lai et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Weak and Nondiscriminative Responses to Conspecifics in the Rat Hippocampus

Heimendahl¹,

Rao²,

Brecht³

2012

J. Neurosci.

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Little is known about how hippocampal neurons in rodents respond to and represent conspecifics. To address this question, we let rats interact while quantifying hippocampal neuronal activation patterns with extracellular recordings and immediate-early gene (c-Fos) expression. A total of 319 single putative pyramidal neurons was recorded in dorsal hippocampus. In sessions with multiple stimulus rats, no cell responded differentially to individual rats (N ϭ 267 cells). We did find, however, that the presence of other rats induced a significant enhancement or suppression of firing in a fraction of neurons (n ϭ 22 of 319; 7%). As expected, a large fraction of neurons (n ϭ 170; 53%) had place fields. There was no evidence for place-independent responses to rats. Rather, the modulations were linked to the spatial responses. While neurons did not discriminate between individual rats, they did discriminate between rats and inanimate objects. Surprisingly, neuronal responses were more strongly modulated by objects than by rats, even though subjects spent more time near their conspecifics. Consistent with the low fraction of rat-modulated cells, social encounters did not induce c-Fos expression in the hippocampus, while there was a social interaction-specific expression in the basolateral amygdala. In both interacting and non-interacting rats, the fraction of c-Fos-expressing cells in the hippocampus was very low. Our investigation of social coding in the rat hippocampus, along with other recent work, showed that social responses were rare and lacked individual specificity, altogether speaking against a role of rodent dorsal hippocampus in social memory.

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“…In an initial study, [13] very little huddling underneath the provided cardboard shelter was observed in a cage of hippocampal lesioned mice. A similar lack of huddling behaviour was observed in hippocampal lesioned degus (Octodon degus) [15]. To use this as a test of species-typical behaviour would not appear to be a practical proposition, however, as groups, rather than individuals would need to be tested, and satisfactory end points might be difficult to define.…”

Section: Tests Of Species Typical Behavioursmentioning

confidence: 83%

“…Two relatively quick and easy further tests were, however, devised following perusal of a "missing persons" document for working police officers [15]. Demented missing people tend to follow boundaries, such as a wall or fence, without crossing through doors or gates.…”

Section: Further Development Of Species-typical Behavioural Testsmentioning

confidence: 99%

A Novel Approach to Discovering Treatments for Alzheimer ’s Disease

Deacon¹

2014

J Alzheimers Dis Parkinsonism

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At present, learning and memory tests are widely used in the preclinical search for treatments for Alzheimer's disease (AD). However, in most cases these tests do not probe "episodic memory" which is the type most affected in AD. This article describes a different approach to preclinical testing -the use of species-typical tasks. These mirror "activities of daily living," impairments of which are noticeable in the earliest stages of the illness. These impairments are frequently more of a problem to the patient than the loss of cognitive abilities, and lead to a need for carers or institutionalisation, both of which can be costly. Species-typical tasks do not require food deprivation or aversive stimulation to motivate the animals; they are performed spontaneously. Moreover they are simple and cheap to execute. Thus they model an aspect of the disease more closely, are cost-effective, simpler and ethically sounder than current practices.

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Hippocampus lesions induced deficits in social and spatial recognition in Octodon degus

Cited by 47 publications

References 28 publications

RECOLLECTION OF WHAT-WHERE-WHICH MEMORY IN DEGUS (<i>OCTODON DEGUS</i>)

RECOLLECTION OF WHAT-WHERE-WHICH MEMORY IN DEGUS (<i>OCTODON DEGUS</i>)

Weak and Nondiscriminative Responses to Conspecifics in the Rat Hippocampus

A Novel Approach to Discovering Treatments for Alzheimer ’s Disease

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