Hippocampal volumes are important predictors for memory function in elderly women

Ystad, Martin; Lundervold, Astri J.; Wehling, Eike; Espeseth, Thomas; Rootwelt, Helge; Westlye, Lars T.; Andersson, Martin; Adólfsdóttir, Steinunn; Geitung, Jonn Terje; Fjell, Anders M.; Reinvang, Ivar; Lundervold, Arvid

doi:10.1186/1471-2342-9-17

Cited by 94 publications

(82 citation statements)

References 64 publications

(68 reference statements)

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“…6A). Since a number of studies have shown that hippocampal volume affects memory functions (29), forced mastication due to a hard diet may be able to indirectly improve memory. For an assessment of neural activity after forced mastication, the expression of c-Fos in the DG of the group fed the hard diet and the group fed the normal diet was evaluated.…”

Section: Discussionmentioning

confidence: 99%

Forced mastication increases survival of adult neural stem cells in the hippocampal dentate gyrus

Akazawa

Kitamura

Fujihara

et al. 2012

International Journal of Molecular Medicine

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Abstract. In this study, we examined the effect of forced mastication on neurogenesis in the hippocampal dentate gyrus (DG) of adult mice. Six-week-old mice were subjected to either a hard or normal diet for 13 weeks. They received a daily injection of bromodeoxyuridine (BrdU) for 12 consecutive days beginning at 14 weeks of age. The number of BrdU-positive cells in the DG was counted 1 day after and 5 weeks after the final BrdU injection. The number of BrdU-positive cells 1 day after injection did not differ between the 2 diet groups. However, the number of BrdU-positive cells in the group fed the hard diet was significantly increased 5 weeks after BrdU injection compared to the group fed the normal diet. The results of the Morris water maze test showed that mice fed a hard diet required significantly less time to reach the platform than the control mice when tested at 10 days. Moreover, mice in the group fed the hard diet spent significantly more time in the former platform area than the group fed the normal diet, indicating that hard diet feeding improved spatial memory compared to normal diet feeding. Real-time PCR analysis showed that the expression of glutamate receptor 1 mRNA was significantly increased in the group fed the hard diet compared with the group fed the normal diet. These results suggest that mastication increases the survival of adult neural stem cells in the hippocampal DG.

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Section: Discussionmentioning

confidence: 99%

Forced mastication increases survival of adult neural stem cells in the hippocampal dentate gyrus

Akazawa

Kitamura

Fujihara

et al. 2012

International Journal of Molecular Medicine

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“…All the participants were subject to a neuropsychological examination and to multimodal imaging. One of the expected outcomes of the study is to understand the relations between imagederived features of the brain and cognitive functions in healthy aging [7]. The study involves 3D anatomical magnetic resonance imaging (MRI) of the brain, followed by diffusion tensor imaging (DTI) and resting state functional MRI in the same imaging session [12] [13].…”

Section: Interactive Visual Analysis Environmentmentioning

confidence: 99%

“…We analyze the data from a longitudinal study of cognitive aging where the participants were chosen among healthy individuals [6] [7]. All the participants were subject to a neuropsychological examination and to multimodal imaging.…”

Section: Interactive Visual Analysis Environmentmentioning

confidence: 99%

“…We discuss how we utilize the dual analysis of items and dimensions [5] in the interactive visual analysis of high dimensional data. We report on the analysis of data related to a longitudinal study of cognitive aging [6] [7]. We demonstrate how our explorative methods lead to findings that are used in the formulation of new research hypotheses in the related study.…”

Section: Introductionmentioning

confidence: 99%

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Hypothesis Generation by Interactive Visual Exploration of Heterogeneous Medical Data

Turkay

Lundervold

Hauser

2013

Human-Computer Interaction and Knowledge Discovery in Complex, Unstructured, Big Data

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Abstract. High dimensional, heterogeneous datasets are challenging for domain experts to analyze. A very large number of dimensions often pose problems when visual and computational analysis tools are considered. Analysts tend to limit their attention to subsets of the data and lose potential insight in relation to the rest of the data. Generating new hypotheses is becoming problematic due to these limitations. In this paper, we discuss how interactive analysis methods can help analysts to cope with these challenges and aid them in building new hypotheses. Here, we report on the details of an analysis of data recorded in a comprehensive study of cognitive aging. We performed the analysis as a team of visualization researchers and domain experts. We discuss a number of lessons learned related to the usefulness of interactive methods in generating hypotheses.

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“…Further, Espeseth et al (2012) link APOE-related changes of cortical thickness to variation in attention. Ystad et al (2009) used both Sonata and GE Signa data to study APOE effects on hippocampal volumes and relations with memory functions. Westlye et al (2011) recently published a study revealing effects of APOE on resting-state connectivity based on the GE Signa data.…”

Section: Mri-based Imagingmentioning

confidence: 99%

Imaging and Cognitive Genetics: The Norwegian Cognitive NeuroGenetics Sample

et al. 2012

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Data collection for the Norwegian Cognitive NeuroGenetics sample (NCNG) was initiated in 2003 with a research grant (to Ivar Reinvang) to study cognitive aging, brain function, and genetic risk factors. The original focus was on the effects of aging (from middle age and up) and candidate genes (e.g., APOE, CHRNA4) in cross-sectional and longitudinal designs, with the cognitive and MRI-based data primarily being used for this purpose. However, as the main topic of the project broadened from cognitive aging to imaging and cognitive genetics more generally, the sample size, age range of the participants, and scope of available phenotypes and genotypes, have developed beyond the initial project. In 2009, a genome-wide association (GWA) study was undertaken, and the NCNG proper was established to study the genetics of cognitive and brain function more comprehensively. The NCNG is now controlled by the NCNG Study Group, which consists of the present authors. Prominent features of the NCNG are the adult life-span coverage of healthy participants with high-dimensional imaging, and cognitive data from a genetically homogenous sample. Another unique property is the large-scale (sample size 300-700) use of experimental cognitive tasks focusing on attention and working memory. The NCNG data is now used in numerous ongoing GWA-based studies and has contributed to several international consortia on imaging and cognitive genetics. The objective of the following presentation is to give other researchers the information necessary to evaluate possible contributions from the NCNG to various multi-sample data analyses.

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Hippocampal volumes are important predictors for memory function in elderly women

Cited by 94 publications

References 64 publications

Forced mastication increases survival of adult neural stem cells in the hippocampal dentate gyrus

Forced mastication increases survival of adult neural stem cells in the hippocampal dentate gyrus

Hypothesis Generation by Interactive Visual Exploration of Heterogeneous Medical Data

Imaging and Cognitive Genetics: The Norwegian Cognitive NeuroGenetics Sample

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