Hippocampal Volume Reduction Correlates With Apathy in Traumatic Brain Injury, But Not Schizophrenia

Takayanagi, Yoichiro; Gerner, Gwendoly; Takayanagi, Mizuho; Rao, Vani; Vannorsdall, Tracy D.; Sawa, Akira; Schretlen, David J.; Cascella, Nicola G.

doi:10.1176/appi.neuropsych.12040093

Cited by 22 publications

(8 citation statements)

References 40 publications

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“…In a heterogeneous group of 60 patients who had suffered traumatic brain injury (TBI), reduced volume within brain regions including medial frontal cortex was associated with greater severity of apathetic features ( Guild and Levine, 2015 ). Another small study of 10 apathetic TBI patients reported that volume loss in the left hippocampus strongly correlated with apathy ( Takayanagi et al, 2013 ). Overall , evidence for the neuroimaging correlates of apathy in TBI is limited, and further research is required to determine whether the associations described for other conditions are also true for this complex entity.…”

Section: The Anatomy Of Apathy Across Disordersmentioning

confidence: 99%

The anatomy of apathy: A neurocognitive framework for amotivated behaviour

2018

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Apathy is a debilitating syndrome associated with many neurological disorders, including several common neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, and focal lesion syndromes such as stroke. Here, we review neuroimaging studies to identify anatomical correlates of apathy, across brain disorders. Our analysis reveals that apathy is strongly associated with disruption particularly of dorsal anterior cingulate cortex (dACC), ventral striatum (VS) and connected brain regions. Remarkably, these changes are consistent across clinical disorders and imaging modalities.Review of the neuroimaging findings allows us to develop a neurocognitive framework to consider potential mechanisms underlying apathy. According to this perspective, an interconnected group of brain regions – with dACC and VS at its core – plays a crucial role in normal motivated behaviour. Specifically we argue that motivated behaviour requires a willingness to work, to keep working, and to learn what is worth working for. We propose that deficits in any one or more of these processes can lead to the clinical syndrome of apathy, and outline specific approaches to test this hypothesis. A richer neurobiological understanding of the mechanisms underlying apathy should ultimately facilitate development of effective therapies for this disabling condition.

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Section: The Anatomy Of Apathy Across Disordersmentioning

confidence: 99%

The anatomy of apathy: A neurocognitive framework for amotivated behaviour

2018

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“…However the amygdala may not be acting in isolation. Takayanagi et al, (2013) reported an association between left hippocampal volume loss and apathy, leading the authors to suggest a left amygdala-hippocampal complex mediating apathy after TBI.…”

Section: Amygdalamentioning

confidence: 99%

Apathy following traumatic brain injury: A review

Worthington

Wood

2018

Neuropsychologia

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Apathy is a common problem after traumatic brain injury (TBI) and can have a major impact on cognitive function, psychosocial outcome and engagement in rehabilitation. For scientists and clinicians it remains one of the least understood aspects of brain-behaviour relationships encompassing disturbances of cognition, motivation, emotion and action, and is variously an indication of organic brain disease or psychiatric disorder. Apathy can be both sign and symptom and has been proposed as a diagnosis in its own right as well as a secondary feature of other conditions. This review considers previous approaches to apathy in terms of relevant psychological constructs and those neural counterparts most likely to be implicated after TBI. Neurobehavioural disorders of apathy are characterised chiefly by dysfunction of executive control of goal-oriented behaviour or the neural substrates of reward-based and emotional learning. We argue that it is possible to distinguish a primary disorder of apathy as an organic neurobehavioural state from secondary presentations due to an impoverished environment or psychological disturbance which has implications for treatment.

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“…37 While the orbitofrontal cortex is suggested to be involved in the value representations of an outcome, the anterior cingulate cortex is suggested to play a role in the computation of the effort needed to obtain an outcome. 32-34 Takayanagi et al 38 did not find any significant associations between severity of apathy and cortical thickness in a group of schizophrenia patients. However, power to detect associations may have been limited given that the study only included 15 patients, all diagnosed with DS.…”

Section: Subdomains Of Negative Symptomsmentioning

confidence: 89%

The Neural Correlates of Negative Symptoms in Schizophrenia: Examples From MRI Literature

2017

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Negative symptoms of schizophrenia have a negative impact on psychosocial functioning and disease outcome. It is therefore important to investigate the pathophysiology underlying negative symptoms as this may aid the development of better treatment. In the current article, examples from studies investigating neural correlates of negative symptoms in schizophrenia are given. Investigations using both structural and functional magnetic resonance imaging are presented at different levels of symptomatology descriptions, from the more heterogenous construct of negative symptoms to more single discrete symptoms. Some methods to improve imaging studies of negative symptoms in schizophrenia are also suggested.

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Hippocampal Volume Reduction Correlates With Apathy in Traumatic Brain Injury, But Not Schizophrenia

Cited by 22 publications

References 40 publications

The anatomy of apathy: A neurocognitive framework for amotivated behaviour

The anatomy of apathy: A neurocognitive framework for amotivated behaviour

Apathy following traumatic brain injury: A review

The Neural Correlates of Negative Symptoms in Schizophrenia: Examples From MRI Literature

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