Hippocampal volume in first-episode schizophrenia and longitudinal course of the illness

Hýža, Martin; Kuhn, Matyáš; Češková, Eva; Ustohal, Libor; Kašpárek, Tomáš

doi:10.1080/15622975.2016.1199893

Cited by 24 publications

(15 citation statements)

References 51 publications

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“…Hýža et al, in a 4‐year longitudinal study found enlarged left CA1 volume in 58 individuals with first‐episode schizophrenia (with a mean duration of untreated psychosis of 7.23 months; 38 with follow‐up clinical data) when compared to 58 healthy controls. They also found a trend‐level negative correlation between duration of untreated psychosis and CA2/3 volume and a positive correlation between right CA1 volume and positive symptom severity.…”

Section: Resultsmentioning

confidence: 99%

“…Most schizophrenia imaging studies using FreeSurfer to estimate hippocampal subregion volumes published to date have employed the first method and atlas . Three FreeSurfer studies have used the second method with the updated hippocampal subregion segmentation atlas run on top of the FreeSurfer 5.3 whole hippocampal segmentation …”

Section: Resultsmentioning

confidence: 99%

“…We excluded any manuscripts based on shape methods based on primary interest in hippocampal subregion volume and physiology findings and because shape findings are difficult to summarize. We identified 13 relevant structural imaging publications [27][28][29][30][31][32][33][34][35][36][37][38][39] (Table 1), and 3 relevant physiological imaging publications [40][41][42] (Table 2).…”

Section: Methodsmentioning

confidence: 99%

“…50 Most schizophrenia imaging studies using FreeSurfer to estimate hippocampal subregion volumes published to date have employed the first method and atlas. 27,28,[30][31][32][33][34] Three FreeSurfer studies have used the second method with the updated hippocampal subregion NAKAHARA ET AL.…”

Section: Structural Abnormalities In Hippocampal Subregions In Schimentioning

confidence: 99%

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Hippocampal subregion abnormalities in schizophrenia: A systematic review of structural and physiological imaging studies

Nakahara

Matsumoto

Erp

2018

Neuropsychopharm Rep

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Aim The hippocampus is considered a key region in schizophrenia pathophysiology, but the nature of hippocampal subregion abnormalities and how they contribute to disease expression remain to be fully determined. This study reviews findings from schizophrenia hippocampal subregion volumetric and physiological imaging studies published within the last decade. Methods The PubMed database was searched for publications on hippocampal subregion volume and physiology abnormalities in schizophrenia and their findings were reviewed. Results The main replicated findings include smaller CA1 volumes and CA1 hyperactivation in schizophrenia, which may be predictive of conversion in individuals at clinical high risk of psychosis, smaller CA1 and CA4/DG volumes in first‐episode schizophrenia, and more widespread smaller hippocampal subregion volumes with longer duration of illness. Several studies have reported relationships between hippocampal subregion volumes and declarative memory or symptom severity. Conclusions Together these studies provide support for hippocampal formation circuitry models of schizophrenia. These initial findings must be taken with caution as the scientific community is actively working on hippocampal subregion method improvement and validation. Further improvements in our understanding of the nature of hippocampal formation subregion involvement in schizophrenia will require the collection of structural and physiological imaging data at submillimeter voxel resolution, standardization and agreement of atlases, adequate control for possible confounding factors, and multi‐method validation of findings. Despite the need for cautionary interpretation of the initial findings, we believe that improved localization of hippocampal subregion abnormalities in schizophrenia holds promise for the identification of disease contributing mechanisms.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Structural Abnormalities In Hippocampal Subregions In Schimentioning

confidence: 99%

See 2 more Smart Citations

Hippocampal subregion abnormalities in schizophrenia: A systematic review of structural and physiological imaging studies

Nakahara

Matsumoto

Erp

2018

Neuropsychopharm Rep

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“…On the other side, it has been well documented that the largest magnitude of subcortical brain volume abnormalities in schizophrenia is in the hippocampus, which can be seen in both the early and chronic stages of this disorder 39,40. Hippocampus is hypothesized to underlie the neuropsychological deficits and symptoms observed in schizophrenia 41,42. Thereby, the role of CFH in schizophrenia could not be excluded, even though we did not detect any association of CFH with schizophrenia at molecular level.…”

Section: Discussionmentioning

confidence: 99%

Influence of <em>CFH</em> gene on symptom severity of schizophrenia

Zhang¹,

Lv²,

Fan³

et al. 2017

NDT

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ObjectiveRecent advances have provided compelling evidence for the role of excessive complement activity in the pathophysiology of schizophrenia. In this study, we aimed to detect the association of the gene encoding complement factor H (CFH), a regulator in complement activation, with schizophrenia.Materials and methodsA sample of 1783 individuals with or without schizophrenia was recruited for genetic analysis. Genomic DNA samples were extracted from peripheral blood cells using multiplex polymerase chain reaction and the SNaPshot assay. A Database for Schizophrenia Genetic Research (SZDB) was used to detect the association of brain CFH expression with schizophrenia. Next, we performed a genotype–phenotype analysis to identify the relationship between CFH Y402H polymorphism and clinical features of schizophrenia.ResultsThere was a significant association of hippocampal CFH expression with schizophrenia (P=0.017), whereas this significance did not survive after adjusting for false discovery rate (P=0.105). Comparing the genotype and allele frequencies of the genotyped single-nucleotide polymorphisms between case and control groups showed no significant difference. There were significant differences in the scores of negative symptoms and delayed memory between the patients with C allele and those without C allele (P<0.01 and P=0.04 after Bonferroni correction, respectively). Furthermore, we observed a marginally significant association between the Y402H polymorphism and CFH expression in the hippocampus (P=0.051); however, this significance was lost after multiple testing correction (P=0.51, after Bonferroni correction).ConclusionOur findings provide suggestive evidence for the role of CFH in the development of negative symptoms and cognitive dysfunction in schizophrenia.

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FreeSurfer‐based segmentation of hippocampal subfields: A review of methods and applications, with a novel quality control procedure for ENIGMA studies and other collaborative efforts

Sämann

Iglesias

Gutman

et al. 2020

Human Brain Mapping

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Structural hippocampal abnormalities are common in many neurological and psychiatric disorders, and variation in hippocampal measures is related to cognitive performance and other complex phenotypes such as stress sensitivity. Hippocampal subregions are increasingly studied, as automated algorithms have become available for mapping and volume quantification. In the context of the Enhancing Neuro Imaging Genetics

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Hippocampal volume in first-episode schizophrenia and longitudinal course of the illness

Cited by 24 publications

References 51 publications

Hippocampal subregion abnormalities in schizophrenia: A systematic review of structural and physiological imaging studies

Hippocampal subregion abnormalities in schizophrenia: A systematic review of structural and physiological imaging studies

Influence of <em>CFH</em> gene on symptom severity of schizophrenia

FreeSurfer‐based segmentation of hippocampal subfields: A review of methods and applications, with a novel quality control procedure for ENIGMA studies and other collaborative efforts

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