Hippocampal Tissue Transplants Reverse Lesion-Induced Spatial Memory Deficits in Zebra Finches (<i>Taeniopygia guttata</i>)

Patel, Sanjay N.; Clayton, N. S.; Krebs, John R.

doi:10.1523/jneurosci.17-10-03861.1997

Cited by 58 publications

(32 citation statements)

References 24 publications

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“…The avian HP appears to be homologous to the mammalian HP based on numerous structural and functional factors (reviewed in Colombo and Broadbent, 2000), including its role in spatial memory used for navigation and the accurate retrieval of stored food (Bingman et al, 1988;Krebs et al, 1989;Biegler et al, 2001). In zebra finches specifically, lesions of the HP result in significant spatial memory impairment, and transplantation of embryonic HP tissue reverses this deficit (Patel et al, 1997). Considering its importance in memory, the results of the present study suggest that the HP may be involved in the formation or utilization of song memories.…”

Section: Discussionmentioning

confidence: 99%

The hippocampus and caudomedial neostriatum show selective responsiveness to conspecific song in the female zebra finch

2002

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The perception of song is vital to the reproductive success of both male and female songbirds. Several neural structures underlying this perception have been identified by examining expression of immediate early genes (IEGs) following the presentation of conspecific or heterospecific song. In the few avian species investigated, areas outside of the circuit for song production contain neurons that are active following song presentation, specifically the caudal hyperstriatum ventrale (cHV) and caudomedial neostriatum (NCM). While studied in detail in the male zebra finch, IEG responses in these neural substrates involved in song perception have not been quantified in females. Therefore, adult female zebra finches were presented with zebra finch song, nonzebra finch song, randomly generated tones, or silence for 30 min. One hour later they were sacrificed, and their brains removed, sectioned, and immunocytochemically processed for FOS expression. Animals exposed to zebra finch song had a significantly higher density of FOS-immunoreactive cells in the NCM than those presented with other songs, tones, or silence. Neuronal activation in the cHV was equivalent in birds that heard zebra finch and non-zebra finch song, expression that was higher than that observed in the groups that heard no song. Interestingly, the hippocampus (HP) and adjacent parahippocampal area (AHP) were activated in a manner comparable to the NCM. These results suggest a general role for the cHV in song perception and a more specific role for the NCM and HP/AHP in facilitating recognition of and responsiveness to species-specific song in female zebra finches.

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Section: Discussionmentioning

confidence: 99%

The hippocampus and caudomedial neostriatum show selective responsiveness to conspecific song in the female zebra finch

2002

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“…As in mammals, such spatial memory requires the integrity of the hippocampus. Bilateral damage to the hippocampus disrupts memory for the location of food caches, but does not affect caching and feeding behaviour per se [27,28]. Food-storing birds have larger hippocampi (relative to total brain size) with more neurons than related nonstoring species [29,30].…”

Section: Neurogenesis In Response To Environmental Demandsmentioning

confidence: 99%

Making more synapses: a way to store information?

Moser¹

1999

Cellular and Molecular Life Sciences (CMLS)

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Although information may be stored in the brain is changes in the strength of existing synapses, formation of new synapses has long been thought of as an additional substrate for memory storage. The identification of subcellular structural changes following learning in mammals poses a serious 'needle-in-the-haystack' problem. In most attempts to demonstrate structural plasticity during learning, animals have been exposed for prolonged periods to complex environments, where they are confronted with a variety of sensory, motor- and spatial challenges throughout the exposure period. These environments are thought to promote several forms of learning. Repeated exposure to such environments has been shown to increase the density of spines and dendritic complexity in relevant brain structures. The number of neurons has also been reported to increase in some areas. It is not clear, however, whether the new synapses emerging from these forms of plasticity mediate specific information storage, or whether they reflect a more general sophistication of the excited parts of the network.

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“…34,73 In addition, the avian hippocampal complex appears to be visceral/limbic in nature and based on the localized presence of multiple neurochemical markers it has been proposed to have four major subdivisions and to be homologous of the Ammon's horn and parahippocampal area of the dentate gyrus in mammals. 49,50,63 The dorsomedial area of the avian hippocampus is rich in GABAergic fibers, that may primarily reflect intrinsic connections and includes the most intense labeling of serotoninergic, cholinergic and catecholaminergic fibers and neuropil of the ascending afferents of the medial fiber tract.…”

Section: Somatosensory Telencephalic and Limbic Areasmentioning

confidence: 99%

Performance of appetitive or consummatory components of male sexual behavior is mediated by different brain areas: a 2-deoxyglucose autoradiographic study

Dermon¹,

Stamatakis²,

Tlemçani³

et al. 1999

Neuroscience

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Abstract-The in vivo autoradiographic deoxyglucose method was used to identify the functional brain circuits that are involved in the performance of appetitive and consummatory components of male sexual behavior in Japanese quail (Coturnix japonica). Two groups of castrated, testosterone-treated male quail were trained during 12 sessions to associate the view of a female behind a window with the opportunity to interact freely and to copulate with her. They developed, as a consequence, a social proximity response (staying close and looking through the window providing a view of the female) that has been used in previous experiments to measure appetitive sexual behavior. A third control group (also castrated and treated with testosterone) was allowed to view the female but not to copulate with her and therefore did not develop this proximity response. 2-14 C-deoxyglucose was then injected i.p. to these birds and they were allowed to either copulate freely with a female (consummatory sexual behavior group) or express the social proximity response (appetitive sexual behavior group). The control group was provided a view of the female but these birds, although they were exposed to the same stimuli as birds in the appetitive group, did not express the social proximity response because they had never learned the association with the opportunity to copulate. Birds were killed 45 min after the deoxyglucose injection and their brains were processed for autoradiography. Densitometric analyses of the autoradiograms revealed that the expression of appetitive or consummatory aspects of male sexual behavior was associated with significant increases by comparison with the control group in the deoxyglucose incorporation in the nucleus mesencephalicus lateralis, pars dorsalis and in the nucleus leminsci lateralis. In addition, an increase in the deoxyglucose incorporation was specifically observed in the paleostriatum primitivum, rostral preoptic area, nucleus intercollicularis, nucleus interpeduncularis and third nerve but a decrease was observed in the dorsomedial part of the hippocampus and in the nucleus nervi oculomotori in birds of the consummatory sexual behavior group by comparison with controls. By contrast, in the appetitive sexual behavior group, significant increases in deoxyglucose incorporation were observed in two telencephalic areas, the intermediate hyperstriatum ventrale and neostriatum caudolaterale by comparison with the controls, but decreases were detected in the stratum griseum et fibrosum superficiale of optic tectum by comparison with the consummatory behavior group.These studies demonstrate that the performance of appetitive or consummatory components of male sexual behavior affects in a specific manner the deoxyglucose uptake and accumulation in specific regions of the quail brain. Changes in metabolic activity were observed in steroid-sensitive areas, in auditory, visual and vocal brain regions, and in brain nuclei related to motor behavior but also in association telencephalic and limbic structures. T...

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Hippocampal Tissue Transplants Reverse Lesion-Induced Spatial Memory Deficits in Zebra Finches (Taeniopygia guttata)

Cited by 58 publications

References 24 publications

The hippocampus and caudomedial neostriatum show selective responsiveness to conspecific song in the female zebra finch

The hippocampus and caudomedial neostriatum show selective responsiveness to conspecific song in the female zebra finch

Making more synapses: a way to store information?

Performance of appetitive or consummatory components of male sexual behavior is mediated by different brain areas: a 2-deoxyglucose autoradiographic study

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