Hippocampal Subfield Volumes in Middle-Aged Adults at Risk of Dementia

McKeever, Anna; Paris, Alvar; Cullen, James; Hayes, L. J.; Ritchie, Craig W.; Ritchie, Karen; Waldman, Adam; Wells, Katie; Busza, Albert L.; Carrière, Isabelle; O’Brien, John; Su, Li

doi:10.3233/jad-200238

Cited by 11 publications

(16 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, atrophy of subiculum and CA1 was also detected at very early stages, in cognitively healthy elders, who later developed MCI or AD as well as in elderly subjects with subjective cognitive decline (SCD) ( Csernansky et al, 2005 ; Apostolova et al, 2010 ; Perrotin et al, 2015 ). In subjects at risk for AD, defined either by APOE4 carrier status or amyloidosis or positive family history, no conclusive subfield atrophy pattern is established yet ( Donix et al, 2010 ; Dounavi et al, 2020 ; McKeever et al, 2020 ; Nadal et al, 2020 ). In healthy aging, no clear subfield volume evolution could be identified to date.…”

Section: Discussionmentioning

confidence: 99%

“…Apostolova et al, 2010;Perrotin et al, 2015). In subjects at risk for AD, defined either by APOE4 carrier status or amyloidosis or positive family history, no conclusive subfield atrophy pattern is established yet (Donix et al, 2010;Dounavi et al, 2020;McKeever et al, 2020;Nadal et al, 2020). In healthy aging, no clear subfield volume evolution could be identified to date.…”

Section: Discussionmentioning

confidence: 99%

“…Episodic memory dysfunction in old-aged persons is closely linked to hippocampal volume loss ( Jack et al, 2000 ; Barnes et al, 2009 ; Dickerson and Eichenbaum, 2010 ; Gorbach et al, 2017 ; Nyberg, 2017 ). Considering a high degree of assumed functional specialization, atrophy of distinct hippocampal subfields may even better reflect earliest pathological changes of AD trajectories ( de Flores et al, 2015a ; Perrotin et al, 2015 ; Lindberg et al, 2017 ; Evans et al, 2018 ; Liang et al, 2018 ; Madusanka et al, 2019 ; Parker et al, 2019 ; Zhao et al, 2019 ; Dounavi et al, 2020 ; McKeever et al, 2020 ; Wong et al, 2020 ; Zhang et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Low Subicular Volume as an Indicator of Dementia-Risk Susceptibility in Old Age

Kagerer

Schroeder

Bergen

et al. 2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

IntroductionHippocampal atrophy is an established Alzheimer’s Disease (AD) biomarker. Volume loss in specific subregions as measurable with ultra-high field magnetic resonance imaging (MRI) may reflect earliest pathological alterations.MethodsData from positron emission tomography (PET) for estimation of cortical amyloid β (Aβ) and high-resolution 7 Tesla T1 MRI for assessment of hippocampal subfield volumes were analyzed in 61 non-demented elderly individuals who were divided into risk-categories as defined by high levels of cortical Aβ and low performance in standardized episodic memory tasks.ResultsHigh cortical Aβ and low episodic memory interactively predicted subicular volume [F(3,57) = 5.90, p = 0.018]. The combination of high cortical Aβ and low episodic memory was associated with significantly lower subicular volumes, when compared to participants with high episodic memory (p = 0.004).DiscussionOur results suggest that low subicular volume is linked to established indicators of AD risk, such as increased cortical Aβ and low episodic memory. Our data support subicular volume as a marker of dementia-risk susceptibility in old-aged non-demented persons.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Low Subicular Volume as an Indicator of Dementia-Risk Susceptibility in Old Age

Kagerer

Schroeder

Bergen

et al. 2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…A secondary aim is to develop a putative model of the associations between trauma, depression, cognitive performance and dementia risk which may guide future longitudinal studies. The study uses data from a cohort of middle-aged persons in which around half have a family history of dementia in whom preclinical hippocampal changes have already been detected [26]. in VBM toolbox of SPM8 (http://www.fil.ion.ucl.ac.uk/spm).…”

Section: Types Of Depressionmentioning

confidence: 99%

Trauma and depressive symptomatology in middle-aged persons at high risk of dementia: the PREVENT Dementia Study

Ritchie

Carrière

Gregory

et al. 2020

J Neurol Neurosurg Psychiatry

Self Cite

View full text Add to dashboard Cite

ObjectiveDepression and trauma are associated with changes in brain regions implicated in Alzheimer’s disease. The present study examined associations between childhood trauma, depression, adult cognitive functioning and risk of dementia.MethodsData from 378 participants in the PREVENT Dementia Study aged 40–59 years. Linear and logistic models were used to assess associations between childhood trauma, depression, dementia risk, cognitive test scores and hippocampal volume.ResultsChildhood trauma was associated with depression and reduced hippocampal volume but not current cognitive function or dementia risk. Poorer performance on a delayed face/name recall task was associated with depression. Childhood trauma was associated with lower hippocampal volume however poorer cognitive performance was mediated by depression rather than structural brain differences.ConclusionDepressive symptomatology may be associated with dementia risk via multiple pathways, and future studies should consider subtypes of depressive symptomatology when examining its relationship to dementia.

show abstract

“…Anatomically, the hippocampal formation consists of multiple, lamellar subdivisions organized along the longitudinal axis of hippocampus, including cornu ammonis 1 (CA1), CA3, CA4, dentate gyrus (DG) and subiculum 4 – 6 . Hippocampal subfields have been reported to be differentially vulnerable to a variety of disorders, including autism, Alzheimer’s disease, schizophrenia, and bipolar disorder 7 – 12 , as well as prodromal disease states and in individuals clinically normal, yet at-risk for disease 13 – 15 .…”

Section: Introductionmentioning

confidence: 99%

Brainwide functional networks associated with anatomically- and functionally-defined hippocampal subfields using ultrahigh-resolution fMRI

Chang

Langella

Tang

et al. 2021

Sci Rep

View full text Add to dashboard Cite

The hippocampus is critical for learning and memory and may be separated into anatomically-defined hippocampal subfields (aHPSFs). Hippocampal functional networks, particularly during resting state, are generally analyzed using aHPSFs as seed regions, with the underlying assumption that the function within a subfield is homogeneous, yet heterogeneous between subfields. However, several prior studies have observed similar resting-state functional connectivity (FC) profiles between aHPSFs. Alternatively, data-driven approaches investigate hippocampal functional organization without a priori assumptions. However, insufficient spatial resolution may result in a number of caveats concerning the reliability of the results. Hence, we developed a functional Magnetic Resonance Imaging (fMRI) sequence on a 7 T MR scanner achieving 0.94 mm isotropic resolution with a TR of 2 s and brain-wide coverage to (1) investigate the functional organization within hippocampus at rest, and (2) compare the brain-wide FC associated with fine-grained aHPSFs and functionally-defined hippocampal subfields (fHPSFs). This study showed that fHPSFs were arranged along the longitudinal axis that were not comparable to the lamellar structures of aHPSFs. For brain-wide FC, the fHPSFs rather than aHPSFs revealed that a number of fHPSFs connected specifically with some of the functional networks. Different functional networks also showed preferential connections with different portions of hippocampal subfields.

show abstract

Hippocampal Subfield Volumes in Middle-Aged Adults at Risk of Dementia

Cited by 11 publications

References 27 publications

Low Subicular Volume as an Indicator of Dementia-Risk Susceptibility in Old Age

Low Subicular Volume as an Indicator of Dementia-Risk Susceptibility in Old Age

Trauma and depressive symptomatology in middle-aged persons at high risk of dementia: the PREVENT Dementia Study

Brainwide functional networks associated with anatomically- and functionally-defined hippocampal subfields using ultrahigh-resolution fMRI

Contact Info

Product

Resources

About