Hippocampal subfield volumes across the healthy lifespan and the effects of MR sequence on estimates

Bussy, Aurélie; Plitman, Eric; Tullo, Stephanie; Salaciak, Alyssa; Bedford, Saashi A.; Farzin, Sarah; Béland, Marie-Lise; Valiquette, Vanessa; Kazazian, Christina; Tardif, Christine; Devenyi, Gabriel A.; Chakravarty, M. Mallar; Initiative, Alzheimer’s Disease Neuroimaging

doi:10.1016/j.neuroimage.2021.117931

Cited by 24 publications

(20 citation statements)

References 102 publications

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“…In a very recent study neither CA1 nor subiculum volumes expressed significant relationships with age (Bussy et al, 2021). Authors suggest, that the observed discrepancies in findings may be explained by different study designs (Bussy et al, 2021).…”

Section: Discussionmentioning

confidence: 90%

“…While some studies found CA1 and subiculum to be most affected by age, others found these regions to be relatively preserved (de Flores et al, 2015a;Voineskos et al, 2015;Daugherty et al, 2016;Malykhin et al, 2017;Amaral et al, 2018). In a very recent study neither CA1 nor subiculum volumes expressed significant relationships with age (Bussy et al, 2021). Authors suggest, that the observed discrepancies in findings may be explained by different study designs (Bussy et al, 2021).…”

Section: Discussionmentioning

confidence: 90%

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Low Subicular Volume as an Indicator of Dementia-Risk Susceptibility in Old Age

Kagerer

Schroeder

Bergen

et al. 2022

Front. Aging Neurosci.

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IntroductionHippocampal atrophy is an established Alzheimer’s Disease (AD) biomarker. Volume loss in specific subregions as measurable with ultra-high field magnetic resonance imaging (MRI) may reflect earliest pathological alterations.MethodsData from positron emission tomography (PET) for estimation of cortical amyloid β (Aβ) and high-resolution 7 Tesla T1 MRI for assessment of hippocampal subfield volumes were analyzed in 61 non-demented elderly individuals who were divided into risk-categories as defined by high levels of cortical Aβ and low performance in standardized episodic memory tasks.ResultsHigh cortical Aβ and low episodic memory interactively predicted subicular volume [F(3,57) = 5.90, p = 0.018]. The combination of high cortical Aβ and low episodic memory was associated with significantly lower subicular volumes, when compared to participants with high episodic memory (p = 0.004).DiscussionOur results suggest that low subicular volume is linked to established indicators of AD risk, such as increased cortical Aβ and low episodic memory. Our data support subicular volume as a marker of dementia-risk susceptibility in old-aged non-demented persons.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 90%

Low Subicular Volume as an Indicator of Dementia-Risk Susceptibility in Old Age

Kagerer

Schroeder

Bergen

et al. 2022

Front. Aging Neurosci.

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“…Automatic Segmentation of Hippocampal Subfields (ASHS; Yushkevich et al, 2015) segmented each participant's hippocampus along the longitudinal axis in native space. ASHS uses multi-atlas label fusion to segment the medial temporal lobes into subfields, and has been well-validated among manual and other automated approaches (Bussy et al, 2021). ASHS was run with the ASHS-PMC-T1 atlas (Xie et al, 2016) in all participants.…”

Section: Participantsmentioning

confidence: 99%

Temporal pole volume is associated with episodic autobiographical memory in healthy older adults

2022

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Recollection of personal past events differs across the lifespan. Older individuals recall fewer episodic details and convey more semantic information than young. Here we examine how gray matter volumes in temporal lobe regions integral to episodic and semantic memory (hippocampus and temporal poles, respectively) are related to age differences in autobiographical recollection. Gray matter volumes were obtained in healthy young (n = 158) and old (n = 105) adults. The temporal pole was demarcated and hippocampus segmented into anterior and posterior regions to test for volume differences between age groups. The Autobiographical Interview was administered to measure episodic and semantic autobiographical memory. Volume associations with episodic and semantic autobiographical memory were then assessed. Brain volumes were smaller for older adults in the posterior hippocampus. Autobiographical memory was less episodic and more semanticized for older versus younger adults. Older adults also showed positive associations between temporal pole volumes and episodic autobiographical recall; in the young, temporal pole volume was positively associated with performance on standard laboratory measures of semantic memory. Exploratory analyses revealed that age‐related episodic autobiographical memory associations with anterior hippocampal volumes depended on sex. These findings suggest that age differences in brain structures implicated in episodic and semantic memory may portend reorganization of neural circuits to support autobiographical memory in later life.

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“…The use of NMF in this study enables a multimodal fusion and dimensionality reduction simultaneously, though unlike similar techniques such as Principal Component Analysis, exact quantification of variance explained is unavailable. Finally, we focus this analysis on the neocortical grey matter which captures a distributed set of brain regions, but this decision makes our study blind to the role of the hippocampus and subcortical structures, both of which have been shown to be heavily involved in brain aging ( Bartsch & Wulff, 2015 ; Bussy, Patel, et al, 2021 ; Bussy, Plitman, et al, 2021 ; Fjell, McEvoy, et al, 2014 ; Tamnes et al, 2013 ; Tullo et al, 2019 ; Walhovd et al, 2011 ). Re-examining this research question using macro-and micro-structural measures of these structures (similar to our previous work in healthy young adults ( R. Patel et al, 2020 ; Robert et al, 2022 ), could provide a pathway forward for reconciling the role of these structures.…”

Section: Discussionmentioning

confidence: 99%