Hippocampal sparing for brain tumor radiotherapy: A retrospective study comparing intensity-modulated radiotherapy and volumetric-modulated arc therapy

Soydemir, Gülşen Pınar; Bilici, Nazli; Tiken, Elif Eda; Balkanay, Ayben Yentek; Sisman, Ali Firat; Karaçetin, Didem

doi:10.4103/jcrt.jcrt_32_19

Cited by 2 publications

(2 citation statements)

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“…This was proved in a study by Soydemir GP et al where hippocampal sparing was significantly improved with optimized IMRT plans compared to standard IMRT plans. 9 The sparing of normal brain at medium and high doses was tremendous despite a single light weighted beam traversing through contralateral brain in 3DCRT plans compared to multiple beams in IMRT plans. Although, in 3DCRT plans we optimized the angle and weightage of beams in 3DCRT plans to minimize normal brain dose but in IMRT plans it was not intruded in beam optimization process.…”

Section: Discussionmentioning

confidence: 99%

Alopecia and neurocognitive dysfunction in Glioblastoma multiforme patients- Prevention feasibillity by dosimetric analysis in conformal radiotherapy techniques

Mehta¹,

Kumar²,

Navitha³

2021

IJPO

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Background: The survival rates of GBM patients have shown improvement. This increases the likelihood of manifesting radiation induced sequelae such as neurocognitive dysfunction, alopecia, and memory loss. This increases the focus on dosimetry of hippocampus, scalp, and normal brain. The present study was designed to compare the dosimetric efficacy of two conformal techniques in terms of OAR's sparing and PTV coverage. Materials and Methods: A total of 10 patients with GBM who had received radical radiotherapy by 3DCRT technique were selected. A corresponding IMRT plan was generated for study purpose (n=20 plans). The dose prescribed to the PTV was 60 Gy in 30 fractions. Other than critical structures, additional delineation of hippocampus, normal brain and skin was done. The dosimetric parameters of PTV and OAR's were compared amongst the two techniques. Results: The IMRT technique led to significant advantage in PTV coverage, dose homogeneity and conformity. A clear advantage with either technique could not be demonstrated in terms of point dose of critical structures. The normal brain and scalp showed significant reduction in doses with IMRT technique. The contralateral Hippocampal avoidance Zone also showed better sparing with IMRT technique but significant difference could not be demonstrated. Conclusion:The better coverage with IMRT technique was particularly observed in cases where PTV was overlapping with critical OAR'S while in rest of the cases coverage was comparable amongst both the techniques. The better sparing of scalp and normal brain may decrease the incidence of alopecia, neurocognitive dysfunction that needs to be clinically validated in future studies.

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Section: Discussionmentioning

confidence: 99%

Alopecia and neurocognitive dysfunction in Glioblastoma multiforme patients- Prevention feasibillity by dosimetric analysis in conformal radiotherapy techniques

Mehta¹,

Kumar²,

Navitha³

2021

IJPO

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“…Hippocampal-avoidance WBRT (HA-WBRT) is a new option to prevent hippocampal damage. Recently, many studies have shown the clinical efficacy of HA-WBRT on brain metastases (65)(66)(67)(68)(69). Although there is a lack of clinical data about HA-WBRT for PCNSL, it is still a promising choice for PCNSL.…”

Section: Hippocampal-avoidance Wbrt (Ha-wbrt)mentioning

confidence: 99%

Recent Progress on Primary Central Nervous System Lymphoma—From Bench to Bedside

Shao

et al. 2021

Front. Oncol.

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Primary central nervous system lymphoma (PCNSL) is a rare subtype of extra-nodal lymphoma. The high relapse rate of PCNSL remains a major challenge to the hematologists, even though patients exhibit high sensitivity to the methotrexate-based chemotherapeutic regimens. Recently, the advent of Bruton’s tyrosine kinase inhibitor (BTKi) and CAR T treatment has made more treatment options available to a proportion of patients. However, whether BTKi monotherapy should be given alone or in combination with conventional chemotherapy is still a clinical question. The status of CAR T therapy for PCNSLs also needs to be elucidated. In this review, we summarized the latest progress on the epidemiology, pathology, clinical manifestation, diagnosis, and treatment options for PCNSLs.

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Hippocampal sparing for brain tumor radiotherapy: A retrospective study comparing intensity-modulated radiotherapy and volumetric-modulated arc therapy

Cited by 2 publications

References 1 publication

Alopecia and neurocognitive dysfunction in Glioblastoma multiforme patients- Prevention feasibillity by dosimetric analysis in conformal radiotherapy techniques

Alopecia and neurocognitive dysfunction in Glioblastoma multiforme patients- Prevention feasibillity by dosimetric analysis in conformal radiotherapy techniques

Recent Progress on Primary Central Nervous System Lymphoma—From Bench to Bedside

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