Hippocampal Remapping and Its Entorhinal Origin

Latuske, Patrick; Kornienko, Olga; Kohler, Laura; Allen, Kevin

doi:10.3389/fnbeh.2017.00253

Cited by 64 publications

(70 citation statements)

References 84 publications

(138 reference statements)

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“…The changes in hippocampal spatial representations were the results of both the appearance and disappearance of place fields and the modulation of firing rate. These observations are consistent with the body of literature showing that changes in an environment (Kentros et al 1998;Anderson and Jeffery 2003), exposure to a different environment (Lever et al 2002;Leutgeb et al 2004Leutgeb et al , 2005 and spatial learning (Frank, Stanley, and Brown 2004;Karlsson and Frank 2008;Dupret et al 2010) induces a fast partial remapping of the spatial representation in the hippocampus (Anderson and Jeffery 2003), with the modulation of within-field firing rate (rate remapping) and the formation of new fields and disappearance of existing ones (global remapping) for different subgroups of neurons (Leutgeb et al 2004(Leutgeb et al , 2005Latuske et al 2018). Consistent with the accumulation of field activity on novel or changed goal locations (Fyhn et al 2002;Dupret et al 2010;Danielseon et al 2016) the ratio emerging fields / vanishing fields was highest at the home and reward locations.…”

Section: Discussionsupporting

confidence: 91%

Single-trial dynamics of hippocampal spatial representations are modulated by reward value

Michon

Krul

Sun³

et al. 2020

Preprint

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Reward value is known to modulate learning speed in spatial memory tasks, but little is known about its influence on the dynamical changes in hippocampal spatial representations. Here, we monitored the trial-to-trial changes in hippocampal place cell activity during the acquisition of place-reward associations with varying reward size. We show a faster reorganization and stabilization of the hippocampal place map when a goal location is associated with a large reward. The reorganization is driven by both rate changes and the appearance and disappearance of place fields. The occurrence of hippocampal replay activity largely followed the dynamics of changes in spatial representations. Replay patterns became more selectively tuned towards behaviorally relevant experiences over the course of learning. These results suggest that high reward value enhances memory retention via accelerating the formation and stabilization of the hippocampal cognitive map and enhancing its reactivation during learning.

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Section: Discussionsupporting

confidence: 91%

Single-trial dynamics of hippocampal spatial representations are modulated by reward value

Michon

Krul

Sun³

et al. 2020

Preprint

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“…Real-time closed-loop replay content detection was activated in a subsequent rest epoch (REST) and in a second exposure to the radial maze (RUN2). The encoding model built using data from RUN1 was also valid for decoding the animal’s position in RUN2 ( Figure 1—figure supplement 3b ), indicating that recordings were stable and spatial representations had not remapped ( Anderson and Jeffery, 2003 ; Latuske et al, 2017 ). To evaluate the online detection performance without distortions of the signal, no actual feedback perturbation of brain activity was applied to the brain.…”

Section: Resultsmentioning

confidence: 96%

Real-time classification of experience-related ensemble spiking patterns for closed-loop applications

Ciliberti

Michon

Kloosterman

2018

eLife

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Communication in neural circuits across the cortex is thought to be mediated by spontaneous temporally organized patterns of population activity lasting ~50 –200 ms. Closed-loop manipulations have the unique power to reveal direct and causal links between such patterns and their contribution to cognition. Current brain–computer interfaces, however, are not designed to interpret multi-neuronal spiking patterns at the millisecond timescale. To bridge this gap, we developed a system for classifying ensemble patterns in a closed-loop setting and demonstrated its application in the online identification of hippocampal neuronal replay sequences in the rat. Our system decodes multi-neuronal patterns at 10 ms resolution, identifies within 50 ms experience-related patterns with over 70% sensitivity and specificity, and classifies their content with 95% accuracy. This technology scales to high-count electrode arrays and will help to shed new light on the contribution of internally generated neural activity to coordinated neural assembly interactions and cognition.

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“…Previous studies have also reported that moderate PAE can reduce mGluR5 receptor function in DG (Galindo et al, 2004) and lead to elevated histamine H3 receptor-mediated inhibition of glutamate release from perforant path nerve terminals (Varaschin et al, 2018). Likewise, the integrity of input from the entorhinal cortex, which forms the most prominent source of perforant path axons, is critical for place cell activity (Latuske et al, 2018), and damage to entorhinal cortical cells can produce a similar loss of place field stability and reduction in spatial tuning (Hales et al, 2014;Schlesiger et al, 2018;Van Cauter et al, 2008).…”

Section: Discussionmentioning

confidence: 95%

Altered hippocampal place cell representation and theta rhythmicity following moderate prenatal alcohol exposure

Harvey¹,

Berkowitz²,

Savage³

et al. 2020

Preprint

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Prenatal alcohol exposure (PAE) leads to profound deficits in spatial memory and synaptic and cellular alterations to the hippocampus that last into adulthood. Neurons in the hippocampus, called place cells, discharge as an animal enters specific places in an environment, establish distinct ensemble codes for familiar and novel places, and are modulated by local theta rhythms. Spatial memory is thought to critically depend on the integrity of hippocampal place cell firing. We therefore tested the hypothesis that hippocampal place cell firing is impaired after PAE by performing in-vivo recordings from the hippocampi (CA1 and CA3) of moderate PAE and control adult rats. Our results show that hippocampal CA3 neurons from PAE rats have reduced spatial tuning. Secondly, CA1 and CA3 neurons from PAE rats are less likely to orthogonalize their firing between directions of travel on a linear track and between contexts in an open arena compared to control neurons. Lastly, reductions in the number of hippocampal place cells exhibiting significant theta rhythmicity and phase precession were observed which may suggest changes to hippocampal microcircuit function. Together, the reduced spatial tuning and sensitivity to context provides a neural systems-level mechanism to explain spatial memory impairment after moderate PAE.

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Hippocampal Remapping and Its Entorhinal Origin

Cited by 64 publications

References 84 publications

Single-trial dynamics of hippocampal spatial representations are modulated by reward value

Single-trial dynamics of hippocampal spatial representations are modulated by reward value

Real-time classification of experience-related ensemble spiking patterns for closed-loop applications

Altered hippocampal place cell representation and theta rhythmicity following moderate prenatal alcohol exposure

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