Hippocampal neurons in the monkey with activity related to the place in which a stimulus is shown

Rolls, Edmund T.; Miyashita, Yasushi; Cahusac, Peter; Kesner, RP; Niki, Hiroaki; Feigenbaum, Janet; Bach, Ludwig

doi:10.1523/jneurosci.09-06-01835.1989

Cited by 210 publications

(140 citation statements)

References 17 publications

(25 reference statements)

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“…There is sparse evidence that within the hippocampus some (ϳ1-2%) cells show activity that reflects the relative recency and familiarity of visual stimuli alone (Brown et al, 1987;Rolls et al, 1993;Xiang and Brown, 1998) or when combined with spatial information (Rolls et al, 1989). Although this evidence seems inconsistent with the results obtained in tests of WSR in experiment 4, any subsequent disruption in entorhinal cortex function that follows fornix transection could account for the results we obtained.…”

Section: Discussioncontrasting

confidence: 75%

Impaired Recency Judgments and Intact Novelty Judgments after Fornix Transection in Monkeys

Charles¹,

Gaffan²,

Buckley³

2004

J. Neurosci.

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Over four experiments based on the delayed matching-to-sample task, fornix-transected and normal control monkeys were presented with a sequence of five sample stimuli and then received intermixed within-session recency (WSR) and between-session recency (BSR) tests in experiment 1, only BSR tests in experiment 2, only absolute novelty (AN) tests in experiment 3, or only WSR tests in experiment 4. In WSR tests, monkeys chose which of two samples had occurred more recently in the immediately preceding sequence. In BSR and AN tests, monkeys were required to choose one sample from the immediately preceding sequence in preference to a foil unseen in the present session (BSR) or an AN foil that had never been presented before. When tests of WSR and BSR were intermixed (experiment 1), fornix monkeys performed below the level of the control monkeys in both types of test, although this difference was not statistically significant. In experiment 2, fornix monkeys were significantly impaired on tests of BSR alone, in which memory for a stimulus presented in an immediately preceding sequence could compete with memory for a foil presented in an earlier training session. In tests of AN (experiment 3), fornix monkeys performed at the same level as control animals in distinguishing a previously experienced stimulus from a previously unseen foil. In experiment 4, fornix transection significantly impaired tests of WSR alone. Taken together, these results suggest that one specialized role of the fornix is to process temporal information.

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Section: Discussioncontrasting

confidence: 75%

Impaired Recency Judgments and Intact Novelty Judgments after Fornix Transection in Monkeys

Charles¹,

Gaffan²,

Buckley³

2004

J. Neurosci.

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“…Another possibility is that the object-place information is integrated within the hippocampus. Electrophysiological recording studies show that the incidence of neuronal response changes related to the familiarity of individual stimuli is low in the hippocampus (Xiang and Brown, 1998); however, hippocampal neurons do respond to spatial location information and on some occasions show a selective response to the position of a stimulus in space (Rolls et al, 1989). Finally, we cannot exclude the possibility that performance of the object-in-place task is a property of the hippocampal-prefrontal-perirhinal circuit as a whole.…”

Section: Discussionmentioning

confidence: 86%

When Is the Hippocampus Involved in Recognition Memory?

Barker¹,

Warburton²

2011

Journal of Neuroscience

668

634

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The role of the hippocampus in recognition memory is controversial. Recognition memory judgments may be made using different types of information, including object familiarity, an object's spatial location, or when an object was encountered. Experiment 1 examined the role of the hippocampus in recognition memory tasks that required the animals to use these different types of mnemonic information. Rats with bilateral cytotoxic lesions in the hippocampus or perirhinal or prefrontal cortex were tested on a battery of spontaneous object recognition tasks requiring the animals to make recognition memory judgments using familiarity (novel object preference); object-place information (object-in-place memory), or recency information (temporal order memory). Experiment 2 examined whether, when using different types of recognition memory information, the hippocampus interacts with either the perirhinal or prefrontal cortex. Thus, groups of rats were prepared with a unilateral cytotoxic lesion in the hippocampus combined with a lesion in either the contralateral perirhinal or prefrontal cortex. Rats were then tested in a series of object recognition memory tasks. Experiment 1 revealed that the hippocampus was crucial for object location, object-in-place, and recency recognition memory, but not for the novel object preference task. Experiment 2 revealed that object-in-place and recency recognition memory performance depended on a functional interaction between the hippocampus and either the perirhinal or medial prefrontal cortices. Thus, the hippocampus plays a role in recognition memory when such memory involves remembering that a particular stimulus occurred in a particular place or when the memory contains a temporal or object recency component.

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“…This kind of modulation has been described among neurons in the entorhinal and perirhinal cortices (28)(29)(30)(31)(32); still, physiological studies in nonhuman primates have generally reported only very low percentages of hippocampal neurons (33, 34)-or in many cases no neurons at all (30,35,36)-displaying such modulation. This apparent inconsistency between the findings from lesion and physiology studies has added to the controversy surrounding the role of the hippocampus in recognition memory.…”

mentioning

confidence: 89%

Recognition memory signals in the macaque hippocampus

Jutras

Buffalo

2009

Proc. Natl. Acad. Sci. U.S.A.

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The hippocampus plays a critical role in recognition memory in both monkeys and humans. However, neurophysiological studies have rarely reported recognition memory signals among hippocampal neurons. The majority of these previous studies used variants of the delayed match-to-sample task; however, studies of the effects of hippocampal damage in monkey and humans have shown that another task of recognition memory, the visual paired-comparison, or visual preferential looking task (VPLT), is more sensitive to hippocampal damage than the delayed matching tasks. Accordingly, to examine possible recognition memory signals in the hippocampus, we recorded the activity of 131 hippocampal neurons in two monkeys performing the VPLT. Eighty-eight neurons (67%) responded significantly to stimulus presentation relative to the baseline prestimulus period. A substantial proportion of these visually responsive neurons (36%) showed significant firing-rate modulations that reflected whether stimuli were novel or familiar. Additionally, these firing-rate modulations were correlated with recognition memory performance on the VPLT such that larger modulations by stimulus novelty were associated with better performance. Together, these results provide evidence for a neural signal in the hippocampus that may support recognition memory performance.medial temporal lobe | monkey | single unit

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Hippocampal neurons in the monkey with activity related to the place in which a stimulus is shown

Cited by 210 publications

References 17 publications

Impaired Recency Judgments and Intact Novelty Judgments after Fornix Transection in Monkeys

Impaired Recency Judgments and Intact Novelty Judgments after Fornix Transection in Monkeys

When Is the Hippocampus Involved in Recognition Memory?

Recognition memory signals in the macaque hippocampus

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