Hippocampal neuron loss due to electric injury in rats: A stereological study

Kurtulus, Ayse; Acar, Kemalettin; Adiguzel, Esat; Boz, Bora

doi:10.1016/j.legalmed.2008.08.001

Cited by 14 publications

(8 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous studies have been carried out in an attempt to clarify the internal signs of the passage of electric current. These findings were confirmed by conducting the experiments on animals , histological investigations , immunohistochemistry , biochemical analysis , and SEM/EDX analysis on humans. Our study focused on possible cardiac histomorphological changes in high and low electrical voltage deaths.…”

Section: Discussionsupporting

confidence: 55%

A Pilot Study on the Diagnosis of Fatal Electrocution by the Detection of Myocardial Microhemorrhages

Gentile

Andreola

Bailo

et al. 2019

Journal of Forensic Sciences

View full text Add to dashboard Cite

In electrocutions, death may be caused by alterations in the heart conduction system provoking ventricular fibrillation. This study aims to identify histological cardiac markers of high-and low-voltage electrocution. Two groups of decedents were evaluated: group A included 14 fatalities caused by high-or low-voltage electrocution and group B (control) included 14 fatalities due to other traumatic or disease causes. Myocardial sampling with microscopic examination was performed on all the hearts using the hematoxylin and eosin and Masson's trichrome stains to investigate morphological characteristics that could indicate the damage caused by high-and low-voltage electrocutions. Interstitial myocardial hemorrhagic infiltration was the only differentiating finding, which was shown only in high-voltage electrocution. This pathological finding has not been previously reported, and it may be specific to high-voltage electrocution deaths. Further studies are warranted.

show abstract

Section: Discussionsupporting

confidence: 55%

A Pilot Study on the Diagnosis of Fatal Electrocution by the Detection of Myocardial Microhemorrhages

Gentile

Andreola

Bailo

et al. 2019

Journal of Forensic Sciences

View full text Add to dashboard Cite

show abstract

“…The author admits that this hypothesis is quite speculative, but draws some support from the study of Kurtulus et al [33]. In that study the authors subjected rats to electric shock with household electricity and found statistically significant loss of neurones in the hippocampus of their rats on day 3 post shock.…”

Section: Conclusion -An Hypothesis For Elimentioning

confidence: 93%

The Origin of Remote Symptoms in Electrical and Lightning Injuries: An Attempt at Explanation and a Hypothesis for Testing

Andrews¹

2012

JLR

View full text Add to dashboard Cite

A hypothesis is proposed for the causation of remote injuries from Electrical and Lightning Injuries(ELI). This theory takes instruction from recent developments in biological psychiatry and in particular the cortisol theory of depression. This is reviewed and its consequences are given.The theory is developed as follows. Cortisol is a known stress hormone, and is likely to be activated by the trauma of an electrical injury. Intense trauma chronically affects the control mechanisms for cortisol production leading to chronic cortisol level excess. Cortisol damages the areas of the brain involved in the memory, learning, and fluency dysfunctions seen in ELI, and leads to loss of volume of those regions, due to cell death. Cortisol levels affect the production of BDNF -Brain Derived Neurotropic Factor -in a proportion of individuals. BDNF exists in polymorphic forms and BDNF in one form can be severely depleted by stress. The brain loses its plasticity as a result. Depression results, and is of a type consistent with ELI.It is hoped this theory will lead to experiments to support it, and will guide the use of medication for the injury.

show abstract

“…One thought [9] invoking the release of humoral substance(s) has been advanced, bearing in mind recent psychiatric research indicating the importance of cortisol and brain-derived neurotrophic factor (BDNF) in the genesis of, in particular, traumatic depression [10]. Consequent loss of hippocampal volume is seen in depression [11-14], and there is some evidence of this finding specifically in electrical injury [15]. …”

Section: Psychiatric Findingsmentioning

confidence: 99%

Towards solving enigmas in electrical injury

Andrews

2012

Critical Care

View full text Add to dashboard Cite

The paper by Park and colleagues in the previous issue of Critical Care highlights vascular changes in electrical injury and finds them to be relatively long-lasting and significant. This finding is consistent with long-lasting disability seen clinically in electrically injured patients. Furthermore, the authors report that the changes seen in the shocked part of the body are accompanied by similar changes that are measurable in other parts of the body but that are not involved with electric current. This latter finding is of significant importance. A psychological syndrome - consistent and predictable - exists following an electrical injury. The causation is enigmatic. Recent psychiatric research indicates the importance of circulating cortisol and brain-derived neurotrophic factor (BDNF), which causes loss of hippocampal volume, in the genesis of depression. This psychiatric research has stimulated a speculative theory of the genesis of the psychological effects of electric shock. The paper by Park and colleagues is circumstantial support for the possibility that such a process is real and available.

show abstract

Hippocampal neuron loss due to electric injury in rats: A stereological study

Cited by 14 publications

References 24 publications

A Pilot Study on the Diagnosis of Fatal Electrocution by the Detection of Myocardial Microhemorrhages

A Pilot Study on the Diagnosis of Fatal Electrocution by the Detection of Myocardial Microhemorrhages

The Origin of Remote Symptoms in Electrical and Lightning Injuries: An Attempt at Explanation and a Hypothesis for Testing

Towards solving enigmas in electrical injury

Contact Info

Product

Resources

About