Hippocampal monoamine changes in the Flinders sensitive line rat: A case for the possible use of selective α2C-AR-antagonists in stress and anxiety disorders in companion animals

Harvey, Brian H.; Uys, Madeleine Monique; Viljoen, Francois P.; Shahid, Mohammed; Sonntag, Quixi; Meyer, Leith C. R.

doi:10.1016/j.rvsc.2021.01.013

Cited by 2 publications

(2 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the limited neurochemical data on depressed children, Dahlström et al (2000) reported elevated serotonin transport activity in depressed juveniles (aged 7-17 years), proposing a compensatory mechanism for the hyposerotonergic state to be at play. That similar findings were observed in adult FSL rat (Hvilsom et al, 2019;Harvey et al, 2021) supports this idea and our current findings. As for norepinephrine levels, although others have reported comparable (Harvey et al, 2021) and reduced (Brand & Harvey, 2017) hippocampal levels in adult FSL rats, our findings (Fig.…”

Section: Juvenile Strain Differencessupporting

confidence: 93%

“…That similar findings were observed in adult FSL rat (Hvilsom et al, 2019;Harvey et al, 2021) supports this idea and our current findings. As for norepinephrine levels, although others have reported comparable (Harvey et al, 2021) and reduced (Brand & Harvey, 2017) hippocampal levels in adult FSL rats, our findings (Fig. 5A) are supported by others (Zangen et al, 1999;Roets et al, 2023) and could be explained by lower α 2 receptor expression in the FSL rat (Landau et al, 2015).…”

Section: Juvenile Strain Differencessupporting

confidence: 93%

See 1 more Smart Citation

Genetically predisposed and resilient animal models of depression reveal divergent responses to early-life adversity

Whitney,

Lindeque,

Kruger

et al. 2023

Acta Neuropsychiatr.

View full text Add to dashboard Cite

Objective: Early-life adversity is one of the strongest predictors of childhood depression, that may be exacerbated by a genetic predisposition to develop depression. We therefore investigated the bio-behavioural effects of an early-life stressor in an accepted rodent model of depression. Methods: The Flinders sensitive (FSL) and resistant (FRL) line rats were subjected to an early-life stressor, whereafter their bio-behavioural response during pubertal onset was evaluated. Male and female pups were maternally separated for 3 h per day from postnatal day 02 (PND02) to 17, when they were also weaned. Control animals were left undisturbed, until weaning on PND21. Depressive-like behaviour was analysed on PND21 and reassessed on PND36. Hippocampal monoamine levels, markers of oxidative stress and metabolic markers implicating mitochondrial function were also measured. Results: On PND21, the non-maternal separation and early weaning (non-MSEW) FSL rats spent 10% more time mobile than their FRL controls in the tail suspension test (TST) yet displayed increased depressive-like behaviour in the forced swim test (FST) on PND36. The depressive-like behaviour coincided with increased hippocampal norepinephrine levels, serotonin turnover and a dysfunctional redox state. Maternal separation and early weaning (MSEW) appeared to initially reduce early-life (PND21) depressive-like behaviour in the TST but then induced depressive-like behaviour on PND36, and increased norepinephrine levels more profoundly in the FRL rats. Conclusion: These findings highlight the need to further investigate the stress response pathway in these animals and that the absence or presence of genetic susceptibility may influence the presentation of early-life adversity effects.

show abstract