Hippocampal LTP modulation and glutamatergic receptors following vestibular loss

Truchet, Bruno; Benoit, Alice; Chaillan, Franck A.; Smith, Paul F.; Philoxene, Bruno; Guillamin, Maryline; Poucet, Bruno; Coquerel, Antoine; Besnard, Stéphane

doi:10.1007/s00429-018-1792-0

Cited by 8 publications

(27 citation statements)

References 52 publications

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“…Besnard et al (2012), using receptor autoradiography, observed an increase in the B max for NMDA receptors in the hippocampus at 2 months following BVL, which involved two sequential UVLs. Benoit et al (2018a) and Truchet et al (2019) recently reported similar results, using either flow cytometry or receptor autoradiography, or both, at 7 and 30 days following BVL. By contrast, Zheng et al (2013) could find no difference in any NMDA receptor subunit in any subregion of the hippocampus at 24 h, 72 h, 1 week, 1 month, or 6 months following BVL.…”

Section: Nmda Receptors In the Hippocampus Following Bvlmentioning

confidence: 65%

“…Unlike the in vitro studies, the in vivo studies have mainly concerned LTP in the hippocampus following BVL rather than UVL (Zheng et al, 2010;Truchet et al, 2019). Notably, neither of the in vivo studies found the decrease in fEPSP FIGURE 8 | NMDA receptor quantitative autoradiography.…”

Section: In Vivo Studiesmentioning

confidence: 99%

“…By contrast, Truchet et al (2019) attempted to induce a ''weak'' or ''moderate'' LTP in order to avoid a possible ceiling effect. The fact that Truchet et al (2019) observed an enhanced LTP of the PS suggests that such an effect might be missed by a ceiling effect in the Zheng et al (2010) study due to the stronger LTP induction paradigm used. found that natural vestibular stimulation could enhance LTP in the hippocampus in vivo.…”

Section: In Vivo Studiesmentioning

confidence: 99%

“…This effect appeared to be mediated by cholinergic input from the medial septum, since an ACh receptor antagonist blocked the effect, as did selective lesions of the septum. How this result might relate to those of Zheng et al (2010) and Truchet et al (2019) is unclear. If the results obtained by Truchet et al (2019) are interpreted as dysfunctional LTP due to reduced input selectivity and increased synaptic noise, then the finding that vestibular stimulation increases LTP, could be interpreted as the opposite effect.…”

Section: In Vivo Studiesmentioning

confidence: 99%

“…How this result might relate to those of Zheng et al (2010) and Truchet et al (2019) is unclear. If the results obtained by Truchet et al (2019) are interpreted as dysfunctional LTP due to reduced input selectivity and increased synaptic noise, then the finding that vestibular stimulation increases LTP, could be interpreted as the opposite effect. However, the data obtained from these two studies and those of Zheng et al (2010) are not necessarily incompatible: when it comes to LTP and memory, the relevant question is not only whether there is more or less LTP, but rather which synapses express LTP.…”

Section: In Vivo Studiesmentioning

confidence: 99%

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Vestibular Modulation of Long-Term Potentiation and NMDA Receptor Expression in the Hippocampus

Smith¹,

Truchet²,

Chaillan³

et al. 2020

Front. Mol. Neurosci.

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Loss of vestibular function is known to cause spatial memory deficits and hippocampal dysfunction, in terms of impaired place cell firing and abnormal theta rhythm. Based on these results, it has been of interest to determine whether vestibular loss also affects the development and maintenance of long-term potentiation (LTP) in the hippocampus. This article summarizes and critically reviews the studies of hippocampal LTP following a vestibular loss and its relationship to NMDA receptor expression, that have been published to date. Although the available in vitro studies indicate that unilateral vestibular loss (UVL) results in reduced hippocampal field potentials in CA1 and the dentate gyrus (DG), the in vivo studies involving bilateral vestibular loss (BVL) do not. This may be due to the differences between UVL and BVL or it could be a result of in vitro/in vivo differences. One in vitro study reported a decrease in LTP in hippocampal slices following UVL; however, the two available in vivo studies have reported different results: either no effect or an increase in EPSP/Population Spike (ES) potentiation. This discrepancy may be due to the different high-frequency stimulation (HFS) paradigms used to induce LTP. The increased ES potentiation following BVL may be related to an increase in synaptic NMDA receptors, possibly increasing the flow of vestibular input coming into CA1, with a loss of selectivity. This might cause increased excitability and synaptic noise, which might lead to a degradation of spatial learning and memory.

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Section: Nmda Receptors In the Hippocampus Following Bvlmentioning

confidence: 65%

Section: In Vivo Studiesmentioning

confidence: 99%

Section: In Vivo Studiesmentioning

confidence: 99%

Section: In Vivo Studiesmentioning

confidence: 99%

Section: In Vivo Studiesmentioning

confidence: 99%

See 3 more Smart Citations

Vestibular Modulation of Long-Term Potentiation and NMDA Receptor Expression in the Hippocampus

Smith¹,

Truchet²,

Chaillan³

et al. 2020

Front. Mol. Neurosci.

Self Cite

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Vestibular-guided visual search

2020

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The amnesic symptoms that accompany vestibular dysfunction point to a functional relationship between the vestibular and visual memory systems. However, little is known about the underpinning cognitive processes. As a starting point, we sought evidence for a type of cross-modal interaction commonly observed between other sensory modalities in which the identification of a target (in this case, visual) is facilitated if earlier coupled to a unique, temporally coincident stimulus from another sensory domain (in this case, vestibular). Participants first performed a visual detection task in which stimuli appeared at random locations within a computerised grid. Unknown to participants, the onset of one particular stimulus was accompanied by a brief, sub-sensory pulse of galvanic vestibular stimulation (GVS). Across two visual search experiments, both old and new targets were identified faster when presented in the grid location at which the GVS-paired visual stimulus had appeared in the earlier detection task. This location advantage appeared to be based on relative rather than absolute spatial co-ordinates since the effect held when the search grid was rotated 90°. Together these findings indicate that when individuals return to a familiar visual scene (here, a 2D grid), visual judgements are facilitated when targets appear at a location previously associated with a unique, task-irrelevant vestibular cue. This novel case of multisensory interplay has broader implications for understanding how vestibular signals inform cognitive processes and helps constrain the growing therapeutic application of GVS.

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Anxiolytic-like effects of YL-IPA08, a potent ligand for the translocator protein (18 kDa) via regulating the synaptic plasticity in hippocampus

Wei,

Yin,

Qiao

et al. 2024

European Journal of Pharmacology

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Hippocampal LTP modulation and glutamatergic receptors following vestibular loss

Cited by 8 publications

References 52 publications

Vestibular Modulation of Long-Term Potentiation and NMDA Receptor Expression in the Hippocampus

Vestibular Modulation of Long-Term Potentiation and NMDA Receptor Expression in the Hippocampus

Vestibular-guided visual search

Anxiolytic-like effects of YL-IPA08, a potent ligand for the translocator protein (18 kDa) via regulating the synaptic plasticity in hippocampus

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