Hippocampal endocannabinoids inhibit spatial learning and limit spatial memory in rats

Robinson, Lianne; McKillop-Smith, Susan; Ross, Nicola L.; Pertwee, Roger G.; Hampson, Robert E.; Platt, Bettina; Riedel, Gernot

doi:10.1007/s00213-007-1012-8

Cited by 55 publications

(42 citation statements)

References 47 publications

(61 reference statements)

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“…Contribution of the endocannabinoid system in the hippocampus is supported by a recent study (438). From a clinical aspect, these studies give a warning to the use of cannabinoid agonists and antagonists to human patients, since it may have adverse side effects on hippocampal functions.…”

Section: Spatial Memorymentioning

confidence: 83%

Endocannabinoid-Mediated Control of Synaptic Transmission

Kano¹,

Ohno‐Shosaku²,

Hashimotodani³

et al. 2009

Physiological Reviews

1,298

1,431

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The discovery of cannabinoid receptors and subsequent identification of their endogenous ligands (endocannabinoids) in early 1990s have greatly accelerated research on cannabinoid actions in the brain. Then, the discovery in 2001 that endocannabinoids mediate retrograde synaptic signaling has opened up a new era for cannabinoid research and also established a new concept how diffusible messengers modulate synaptic efficacy and neural activity. The last 7 years have witnessed remarkable advances in our understanding of the endocannabinoid system. It is now well accepted that endocannabinoids are released from postsynaptic neurons, activate presynaptic cannabinoid CB1 receptors, and cause transient and long-lasting reduction of neurotransmitter release. In this review, we aim to integrate our current understanding of functions of the endocannabinoid system, especially focusing on the control of synaptic transmission in the brain. We summarize recent electrophysiological studies carried out on synapses of various brain regions and discuss how synaptic transmission is regulated by endocannabinoid signaling. Then we refer to recent anatomical studies on subcellular distribution of the molecules involved in endocannabinoid signaling and discuss how these signaling molecules are arranged around synapses. In addition, we make a brief overview of studies on cannabinoid receptors and their intracellular signaling, biochemical studies on endocannabinoid metabolism, and behavioral studies on the roles of the endocannabinoid system in various aspects of neural functions.

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Section: Spatial Memorymentioning

confidence: 83%

Endocannabinoid-Mediated Control of Synaptic Transmission

Kano¹,

Ohno‐Shosaku²,

Hashimotodani³

et al. 2009

Physiological Reviews

1,298

1,431

View full text Add to dashboard Cite

show abstract

“…Some studies reported that intrahippocampal infusions of cannabinoid agonists impair either the encoding or consolidation of memory of water-maze spatial, inhibitory avoidance, or object recognition training (33,34), whereas others found enhancing effects (35). Moreover, it has been reported that the CB1 receptor antagonist AM251 infused into the hippocampus impairs memory consolidation of inhibitory avoidance training (36).…”

Section: Discussionmentioning

confidence: 99%

Endocannabinoids in the rat basolateral amygdala enhance memory consolidation and enable glucocorticoid modulation of memory

Campolongo

Roozendaal

Trezza

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

263

209

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“…Conversely, genetic and pharmacological blockade of CB1 leads to deficits in extinction processes (877), whereas the selective inactivation of hippocampal CB1 may enhance memory (730). Pharmacologically elevated AEA levels through FAAH inhibition impair hippocampal-dependent learning and memory tasks (45), and blockade of 2-AG hydrolysis interferes with memory performance (307).…”

Section: Spatial Memorymentioning

confidence: 99%

From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology

Ligresti¹,

Petrocellis²,

Marzo³

2016

Physiological Reviews

366

337

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Apart from having been used and misused for at least four millennia for, among others, recreational and medicinal purposes, the cannabis plant and its most peculiar chemical components, the plant cannabinoids (phytocannabinoids), have the merit to have led humanity to discover one of the most intriguing and pleiotropic endogenous signaling systems, the endocannabinoid system (ECS). This review article aims to describe and critically discuss, in the most comprehensive possible manner, the multifaceted aspects of 1) the pharmacology and potential impact on mammalian physiology of all major phytocannabinoids, and not only of the most famous one ⌬ 9 -tetrahydrocannabinol, and 2) the adaptive prohomeostatic physiological, or maladaptive pathological, roles of the ECS in mammalian cells, tissues, and organs. In doing so, we have respected the chronological order of the milestones of the millennial route from medicinal/recreational cannabis to the ECS and beyond, as it is now clear that some of the early steps in this long path, which were originally neglected, are becoming important again. The emerging picture is rather complex, but still supports the belief that more important discoveries on human physiology, and new therapies, might come in the future from new knowledge in this field.

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Hippocampal endocannabinoids inhibit spatial learning and limit spatial memory in rats

Cited by 55 publications

References 47 publications

Endocannabinoid-Mediated Control of Synaptic Transmission

Endocannabinoid-Mediated Control of Synaptic Transmission

Endocannabinoids in the rat basolateral amygdala enhance memory consolidation and enable glucocorticoid modulation of memory

From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology

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