Hippocampal deformation mapping in MRI negative PET positive temporal lobe epilepsy

Hogan, Robert; Carne, Ross; Kilpatrick, Christine; Cook, Mark; Patel, Anish H.; King, L.G.; O’Brien, Terence J.

doi:10.1136/jnnp.2007.123406

Cited by 25 publications

(23 citation statements)

References 31 publications

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“…Computational anatomic techniques produce 3-dimensional surface representations of the hippocampus with resolution at a subvoxel level, enabling visualization of details of hippocampal surface anatomy (18). Changes in morphology can be detected even when total hippocampal volume changes are not significantly different (19)(20)(21)(22), using either visual analysis of deformation surfaces or multivariate ANOVA on the coefficients from eigenvector fields (23). Originally developed for human studies, this method has been adapted and validated for the assessment of rat hippocampus (16,17).…”

Section: Large-deformation High-dimensional Mapping (Hdm-ld) Of Hippomentioning

confidence: 99%

Progressive Metabolic and Structural Cerebral Perturbations After Traumatic Brain Injury: An In Vivo Imaging Study in the Rat

Liu¹,

Cardamone²,

Hogan³

et al. 2010

J Nucl Med

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Traumatic brain injury (TBI) has a high incidence of long-term neurologic and neuropsychiatric morbidity. Metabolic and structural changes in rat brains were assessed after TBI using serial 18 F-FDG PET and 3-dimensional MRI in vivo. Methods: Rats underwent lateral fluid percussion injury (FPI; n 5 16) or a sham procedure (n 5 11). PET and MR images were acquired at 1 wk and at 1, 3, and 6 mo after injury. Morphologic changes were assessed using MRI-based regions of interest, and hippocampal shape changes were assessed with large-deformation highdimensional mapping. Metabolic changes were assessed using region-of-interest analysis and statistical parametric mapping with the flexible factorial analysis. Anxiety-like behavior and learning were assessed at 1, 3, and 6 mo after injury. Results: PET analyses showed widespread hypometabolism in injured rats, in particular involving the ipsilateral cortex, hippocampus, and amygdalae, present at 1 wk after FPI, most prominent at 1 mo, and then decreasing. Compared with the sham group, rats in the FPI group had decreased structural volume which progressively increased over 3-6 mo, occurring in the ipsilateral cortex, hippocampus, and ventricles after FPI (P , 0.05). Largedeformation high-dimensional mapping showed evolving hippocampal shape changes across the 6 mo after FPI. Injured rats displayed increased anxiety-like behavior (P , 0.05), but there were no direct correlations between the severity of the behavior abnormalities and functional or structural imaging changes. Conclusion: In selected brain structures, FPI induces early hypometabolism and delayed progressive atrophic changes that are dynamic and continue to evolve for months. These findings have implications for the understanding of the pathophysiology and evolution of long-term neurologic morbidity following TBI, and indicate an extended window for targeted neuroprotective interventions.

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Section: Large-deformation High-dimensional Mapping (Hdm-ld) Of Hippomentioning

confidence: 99%

Progressive Metabolic and Structural Cerebral Perturbations After Traumatic Brain Injury: An In Vivo Imaging Study in the Rat

Liu¹,

Cardamone²,

Hogan³

et al. 2010

J Nucl Med

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“…Indeed, a few studies have shown a rather consistent finding of ipsilateral CA1 atrophy in patients with unilateral MTLE, but with some discrepancies with regard to involvement of contralateral hippocampus and other ipsilateral subfields such as CA2-4, DG, or subiculum (Bernhardt et al, 2013;Hogan et al, 2004Hogan et al, , 2008Mumoli et al, 2013). Interestingly, a recent study showed that temporal lobe epilepsy patients with normal hippocampal volume had local hippocampal shape changes (atrophy) mainly affecting subicular and hilar/dentate regions, a distinct pattern from the typical CA1 atrophy found in patients with MTLE (Maccotta et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Volumetric and shape analysis of hippocampal subfields in unilateral mesial temporal lobe epilepsy with hippocampal atrophy

2015

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“…Hogan et al showed reproducibility of 92% overlap of sequential deformation-based hippocampal segmentations in subjects with epilepsy and mesial temporal sclerosis (15). HDM-LD identifies subtle neuroanatomical and longitudinal changes in diseases such as epilepsy, Alzhiemer's disease, depression, and schizophrenia, that are not detectable with standard volumetric methods (3,(17)(18)(19).…”

mentioning

confidence: 99%

MRI‐based large deformation high dimensional mapping of the hippocampus in rats: Development and validation of the technique

Hogan

Bouilleret

Liu

et al. 2009

Magnetic Resonance Imaging

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Purpose:To report the detection of structural and functional biological changes in living animals using small animal in vivo MRI that complements traditional ex vivo histological techniques. We report the development and validation of the application of large deformation high dimensional mapping (HDM-LD) segmentation for the hippocampus in the rat. Materials and Methods:High resolution volumetric T2 weighted MRI images were acquired at 4.7 Tesla from six male in-breed nonepileptic Wistar rats. Two HDM-LD segmentations of the hippocampus (automated 1 and automated 2) were compared with the manual segmentations of two investigators who independently segmented the hippocampi (manual 1 and manual 2). Results:The mean overlap for the hippocampi between automated 1 and automated 2 for the right hippocampi was 94.4% (SD 1.0) and for the left hippocampi was 94.3% (SD 2.5), while the mean overlap between automated 1 and manual 1 for the right hippocampi was 91.4% (SD 1.3) and for the left hippocampi was 91.9% (SD 1.4). Mean values for absolute differences for comparisons of all the segmentations were the following: automated 1 versus automated 2, 3.2% (SD 1.0); manual 1 versus manual 2 6.82% (SD 5.22); automated 1 versus manual 1 13.0% (SD 1.8).Conclusion: HDM-LD can be applied to obtain accurate and reproducible three-dimensional segmentations of the hippocampus from rat MR images. HDM-LD will be a useful tool for investigations of hippocampal structural changes in vivo in rat models of human disease.

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Hippocampal deformation mapping in MRI negative PET positive temporal lobe epilepsy

Abstract: We conclude that differences in segmental volume loss between the HS-ve and HS+ve groups are suggestive that the underlying pathophysiology of hippocampal changes in the two groups is different, and not related to chronic seizure duration or severity.

Cited by 25 publications

References 31 publications

Progressive Metabolic and Structural Cerebral Perturbations After Traumatic Brain Injury: An In Vivo Imaging Study in the Rat

Progressive Metabolic and Structural Cerebral Perturbations After Traumatic Brain Injury: An In Vivo Imaging Study in the Rat

Volumetric and shape analysis of hippocampal subfields in unilateral mesial temporal lobe epilepsy with hippocampal atrophy

MRI‐based large deformation high dimensional mapping of the hippocampus in rats: Development and validation of the technique

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