Hippocampal Atrophy in Persons With Age-Associated Memory Impairment: Volumetry Within a Common Space

Mega, Michael S.; Small, Gary W.; Xu, Mina L.; Felix, Jenaro; Manese, Mario; Tran, Nha P; Dailey, Jason I.; Ercoli, Linda M.; Bookheimer, Susan Y.; Toga, Arthur W.

doi:10.1097/00006842-200205000-00013

Cited by 43 publications

(23 citation statements)

References 36 publications

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“…7% larger than the left one [13,14], and the interhemispheric asymmetry of the hippocampi is related to memory lateralisation (serious memory loss following a removal of the left hippocampus, and not the right one, was found) [15]. Asymmetry reversal may be a sign of one-sided intensity of the disease [16][17][18][19]. Hippocampal volume is reversely related to age, i.e.…”

Section: Purposementioning

confidence: 99%

“…Hippocampal volume is reversely related to age, i.e. after 65 years of age, the volume is reduced in 14-45 mm 3 per year of the total volume, this reduction being nearly linear [14,18,20]. This process accelerates in various diseases when the change in the volume of the left hippocampus reveals faster [16,21].…”

Section: Purposementioning

confidence: 99%

“…U zdrowych osób praworęcznych prawy hipokamp jest większy niż lewy o ok. 7% [13,14], a asymetria między-półkulowa hipokampów jest związana z lateralizacją pamięci (opisywano poważne uszkodzenie pamięci jako skutek usunięcia lewego, a nie prawego hipokampa) [15]. Odwrócenie asymetrii może świadczyć o jednostronnym nasileniu procesu chorobowego [16][17][18][19]. Objętość hipokampa wykazuje odwrotną korelację z wiekiem: po 65. roku życia ulega zmniejszeniu o 14-45 mm 3 /rok łącz-nej objętości, a spadek ma charakter prawie liniowy [14,18,20].…”

Section: Purposeunclassified

“…Odwrócenie asymetrii może świadczyć o jednostronnym nasileniu procesu chorobowego [16][17][18][19]. Objętość hipokampa wykazuje odwrotną korelację z wiekiem: po 65. roku życia ulega zmniejszeniu o 14-45 mm 3 /rok łącz-nej objętości, a spadek ma charakter prawie liniowy [14,18,20]. Proces ten ulega przyspieszeniu w różnych stanach chorobowych, wówczas zmiana objętości mniejszego hipokampa ujawnia się szybciej [16,21].…”

Section: Purposeunclassified

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Reduction in the volume of the front part of the hippocampus in schizophrenics with hyponatremia on hospital admission

Woźniak¹,

Olędzka-Oręziak²,

Poniatowska³

et al. 2017

ppn

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Purpose: Evaluation of the volume of the front part of hippocampi in schizophrenics with hyponatremia on psychiatric ward admission. Methods: Hippocampal volumes were compared across a group of 11 schizophrenics with hyponatremia and 22 patients with normonatremia, in the whole groups and in 11 couples matched in terms of gender, age and the disease duration. The groups were characterised in terms of demographic (gender, age) and clinical (course of illness, pharmacotherapy, tobacco smoking) features. All the participants were right-handed. The hippocampal volumes were manually measured on the basis of the magnetic resonance imaging (MRI), using manual contouring, separately and jointly for the right and left hippocampus, then the obtained results were standardised for the maximum transverse brain diameter (MTBD), the maximum trans-pineal inner table diameter (LTID) or the height. Results: No relation was found between hyponatremia and the MTBD. In patients with hyponatremia, a smaller volume of the left hippocampus was observed, both using direct measurement and after standardisation for the MTBD. The analysis of regression indicates a relation model, in which the reduction in the left hippocampus is explained by the covariance of hyponatremia and MTBD values. Conclusions: Dependency of reduction in the volume of the left hippocampus on hyponatremia observed in patients with schizophrenia encourages a number of pathogenic hypotheses whose interpretation, however, urges caution as the phenomenon itself is complex, and methodological limitations of the undertaken research are present.

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Section: Purposementioning

confidence: 99%

Section: Purposementioning

confidence: 99%

Section: Purposeunclassified

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Reduction in the volume of the front part of the hippocampus in schizophrenics with hyponatremia on hospital admission

Woźniak¹,

Olędzka-Oręziak²,

Poniatowska³

et al. 2017

ppn

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“…MRI studies comparing clinically defined groups similar to CIND to normal age-matched controls have consistently found volumetric reductions in medial temporal lobe structures in those with cognitive complaints [7] , with age-associated memory impairment [8] or with mild cognitive impairment (MCI) [9][10][11] . In turn medial temporal lobe volume reductions predict subsequent progression to AD in these groups [7,10,12,13] .…”

Section: Introductionmentioning

confidence: 99%

Cognitive Impairment No Dementia – Neuropsychological and Neuroimaging Characterization of an Amnestic Subgroup

Jacova

Peters

Beattie³

et al. 2008

Dement Geriatr Cogn Disord

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Background/Aims: Cognitive impairment no dementia (CIND) describes individuals whose cognitive functioning falls below normal but who do not meet dementia criteria. An important goal within CIND is to identify subgroups that will predictably progress to Alzheimer disease. CIND with amnestic deficits has been associated with high risk of Alzheimer disease but has until now been investigated on a retrospective basis. In this study a prospectively defined amnestic CIND group was characterized on a detailed neuropsychological test battery and on structural magnetic resonance imaging (MRI) measures. Methods: Amnestic CIND was defined as meeting at least 1 but not all DSM-IV-TR criteria for dementia, scoring ≧1 SD below norms on Rey Auditory Verbal Learning Test delayed recall, having a Clinical Dementia Rating score of 0.5 and a Mini-Mental State Exam score ≧24. This cross-sectional study compared subjects meeting these criteria (n = 25) to age- and education-matched controls (n = 26). The neuropsychological battery included memory and nonmemory measures that were analyzed as continuous variables and dichotomized into impaired (≧1 SD below controls) versus nonimpaired. MRI scans were evaluated with a global-brain volumetric measure [brain fractional ratio (BFR)] and with visually based medial temporal lobe atrophy (MTA) ratings. Results: Amnestic CIND had neuropsychological impairment in the episodic memory domain and also in nonmemory domains. There were 80% of CIND subjects with multidomain impairment. The most clear-cut nonmemory impairment was in the verbal ability domain, with 64% of subjects affected and a moderate effect size (d = 0.7). On MRI, BFR was lower (74.5 ± 4.6 vs. 75.5 ± 4.4) and MTA higher (72 vs. 38% with MTA ≧1) in CIND than in control subjects. BFR correlated with MTA (r = –0.45) and with a composite memory score (r = 0.296). Conclusion: A prospective amnestic CIND grouping appears to identify individuals with a multidomain pattern of neuropsychological impairment and with both medial temporal lobe and global brain atrophy.

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Current Awareness in Geriatric Psychiatry

2002

Int J Geriat Psychiatry

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of geriatric psychiatry. Each bibliography is divided into 9 sections: 1 Books, Reviews & Symposia; 2 General; 3 Assessment; 4 Epidemiology; 5 Therapy; 6 Care; 7 Dementia; 8 Depression; 9 Psychology. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted

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Hippocampal Atrophy in Persons With Age-Associated Memory Impairment: Volumetry Within a Common Space

Abstract: A growing body of work suggests the right hippocampal head as an early site of atrophy in early memory impairment. Subtle atrophic changes are detectable within a common atlas template allowing imaging assessment across centers.

Cited by 43 publications

References 36 publications

Reduction in the volume of the front part of the hippocampus in schizophrenics with hyponatremia on hospital admission

Reduction in the volume of the front part of the hippocampus in schizophrenics with hyponatremia on hospital admission

Cognitive Impairment No Dementia – Neuropsychological and Neuroimaging Characterization of an Amnestic Subgroup

Current Awareness in Geriatric Psychiatry

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