Hippocampal atrophy and quantitative EEG markers in mild cognitive impairment in temporal lobe epilepsy versus extra-temporal lobe epilepsy

El-Sherif, Mohammed; Esmael, Ahmed

doi:10.1007/s10072-021-05540-4

Cited by 8 publications

(3 citation statements)

References 71 publications

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“…A meta-analysis ( Novak et al, 2022a ) has found that duration of epilepsy, frequency of seizures, and use of antiseizures medications are important clinical features that can affect cognition. Moreover, some studies suggest that education, history of surgical head trauma, anxiety and depression, hippocampal abnormalities, TLE, and seizure types may influence cognitive functions in PWEs ( Piazzini et al, 2006 ; Bell et al, 2011 ; Vrinda et al, 2019 ; Jarcuskova et al, 2020 ; Wang et al, 2020 ; Phuong et al, 2021 ; Elsherif and Esmael, 2022 ). A previous study ( Lin et al, 2021 ) collected 12 clinical features from outpatients with epilepsy to construct a model for diagnosing CI with a performance accuracy, recall, precision, and AUC of 60, 51, 88, and 0.71%, respectively, and concluded that status epilepticus, history of previous surgical head trauma, and seizure frequency were the top three clinical features affecting cognition.…”

Section: Discussionmentioning

confidence: 99%

An objective model for diagnosing comorbid cognitive impairment in patients with epilepsy based on the clinical-EEG functional connectivity features

et al. 2023

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ObjectiveCognitive impairment (CI) is a common disorder in patients with epilepsy (PWEs). Objective assessment method for diagnosing CI in PWEs would be beneficial in reality. This study proposed to construct a diagnostic model for CI in PWEs using the clinical and the phase locking value (PLV) functional connectivity features of the electroencephalogram (EEG).MethodsPWEs who met the inclusion and exclusion criteria were divided into a cognitively normal (CON) group (n = 55) and a CI group (n = 76). The 23 clinical features and 684 PLVEEG features at the time of patient visit were screened and ranked using the Fisher score. Adaptive Boosting (AdaBoost) and Gradient Boosting Decision Tree (GBDT) were used as algorithms to construct diagnostic models of CI in PWEs either with pure clinical features, pure PLVEEG features, or combined clinical and PLVEEG features. The performance of these models was assessed using a five-fold cross-validation method.ResultsGBDT-built model with combined clinical and PLVEEG features performed the best with accuracy, precision, recall, F1-score, and an area under the curve (AUC) of 90.11, 93.40, 89.50, 91.39, and 0.95%. The top 5 features found to influence the model performance based on the Fisher scores were the magnetic resonance imaging (MRI) findings of the head for abnormalities, educational attainment, PLVEEG in the beta (β)-band C3-F4, seizure frequency, and PLVEEG in theta (θ)-band Fp1-Fz. A total of 12 of the top 5% of features exhibited statistically different PLVEEG features, while eight of which were PLVEEG features in the θ band.ConclusionThe model constructed from the combined clinical and PLVEEG features could effectively identify CI in PWEs and possess the potential as a useful objective evaluation method. The PLVEEG in the θ band could be a potential biomarker for the complementary diagnosis of CI comorbid with epilepsy.

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Section: Discussionmentioning

confidence: 99%

An objective model for diagnosing comorbid cognitive impairment in patients with epilepsy based on the clinical-EEG functional connectivity features

et al. 2023

View full text Add to dashboard Cite

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“…A meta-analysis (Novak et al, 2022a) has found that duration of epilepsy, frequency of seizures, and use of antiseizures medications are important clinical features that can affect cognition. Moreover, some studies suggest that education, history of surgical head trauma, anxiety and depression, hippocampal abnormalities, TLE, and seizure types may influence cognitive functions in PWEs (Piazzini et al, 2006;Bell et al, 2011;Vrinda et al, 2019;Jarcuskova et al, 2020;Wang et al, 2020;Phuong et al, 2021;Elsherif and Esmael, 2022). A previous study (Lin et al, 2021) collected 12 clinical features from outpatients with epilepsy to construct a model for diagnosing CI with a performance accuracy, recall, precision, and AUC of 60, 51, 88, and 0.71%, respectively, and concluded that status epilepticus, history of previous surgical head trauma, and seizure frequency were the top three clinical features affecting cognition.…”

Section: Advantages Of Combined Clinical-plv Eeg Features For Classif...mentioning

confidence: 99%

Novel Applications of Bayesian and Other Models in Translational Neuroscience

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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“…Temporal lobe epilepsy (TLE) is the most common type of epilepsy, which is prone to develop into DRE. Due to abnormal brain discharges originating focally in the temporal lobe and limbic system involving cognitive function and emotion, patients with TLE often suffer from different degrees of cognitive impairment and neuropsychiatric disorders (3)(4)(5)(6). These comorbidities severely affect patients' quality of life and burden the family and society (7).…”

Section: Introductionmentioning

confidence: 99%

Effects of long-term supplementation of probiotics on cognitive function and emotion in temporal lobe epilepsy

Wang

Ma²,

Liu³

et al. 2022

Front. Neurol.

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Cognitive impairment and neuropsychiatric disorders are very common in patients with temporal lobe epilepsy (TLE). These comorbidities complicate the treatment of epilepsy and seriously affect the quality of life. So far, there is still no effective intervention to prevent the development of epilepsy-associated comorbidities. Gut dysbiosis has been recognized to be involved in the pathology of epilepsy development. Modulating gut microbiota by probiotics has shown an antiseizure effect on humans and animals with epilepsy. Whether this treatment strategy has a positive effect on epilepsy-associated comorbidities remains unclear. Therefore, this study aimed to objectively assess the effect of probiotics on cognitive function and neuropsychiatric performance of patients with TLE. Participants enrolled in an epilepsy clinic were randomly assigned to the probiotic and placebo groups. These two groups were treated with probiotics or placebo for 12 weeks, and then the cognitive function and psychological performance of participants were assessed. We enrolled 76 participants in this study, and 70 subjects were finally included in the study (35 in the probiotics group and 35 in the placebo group). Our results showed significant seizure reduction in patients with TLE treated with probiotics. No significant differences were observed on cognitive function (including intelligence and memory) between groups. For neuropsychiatric performances, supplementation of probiotics significantly decreased the Hamilton Anxiety Rating and Depression Scale scores and increased the 89-item Quality of Life in Epilepsy Inventory score in patients with TLE. In conclusion, probiotics have a positive impact on seizures control, and improve anxiety, depression, and quality of life in patients with TLE.

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Hippocampal atrophy and quantitative EEG markers in mild cognitive impairment in temporal lobe epilepsy versus extra-temporal lobe epilepsy

Cited by 8 publications

References 71 publications

An objective model for diagnosing comorbid cognitive impairment in patients with epilepsy based on the clinical-EEG functional connectivity features

An objective model for diagnosing comorbid cognitive impairment in patients with epilepsy based on the clinical-EEG functional connectivity features

Novel Applications of Bayesian and Other Models in Translational Neuroscience

Effects of long-term supplementation of probiotics on cognitive function and emotion in temporal lobe epilepsy

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