Hippocampal atrophy and memory dysfunction in patients with juvenile myoclonic epilepsy

Lin, Kátia; Filho, Gerardo Maria de Araújo; Pascalicchio, Tatiana Frascareli; Silva, Ivaldo; Tudesco, Ivanda Souza Silva; Guaranha, Mirian Salvadori Bittar; Júnior, Henrique Carrete; Jackowski, Andrea Parolin; Yacubian, Elza Márcia Targas

doi:10.1016/j.yebeh.2013.06.034

Cited by 28 publications

(25 citation statements)

References 36 publications

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“…This study confirms IQ preservation in JME patients, although in the lower average range, particularly in patients with praxis induction [8,12] and differently from others, there was no difference among groups in tests evaluating hippocampal functions [13,15]. JME patients in group 4, who expressed language/ praxis and eye closure/photo sensitivity, had a worse performance in Trail Making Test B when compared to those without any reflex trait.…”

Section: Neuropsychological Resultssupporting

confidence: 77%

“…This network also subserves executive functions and various studies have provided evidence for different degrees of executive dysfunction and prospective memory impairment [6][7][8][9][10][11][12]. Other cognitive functions, such as hippocampal episodic memory, are relatively preserved though there have been reports of more widespread cognitive involvement [13]. The degree of executive deficits in these patients is variable and cognitive dysfunction does not follow a specific pattern on neuropsychological studies [14].…”

Section: Introductionmentioning

confidence: 99%

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Cognitive performance in juvenile myoclonic epilepsy patients with specific endophenotypes

Carvalho

Uchida

Guaranha

et al. 2016

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Section: Neuropsychological Resultssupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Cognitive performance in juvenile myoclonic epilepsy patients with specific endophenotypes

Carvalho

Uchida

Guaranha

et al. 2016

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“…Lastly, the necessary neuropsychological tests to measure frontal or temporal dysfunction in JME patients were not performed in this study. Previous studies have found that patients with JME have a high frequency of frontal executive dysfunction [6,8] as well as verbal or visual memory dysfunction associated with decreased hippocampal or temporal neural activity [42,45]. Importantly, the present findings demonstrate specific novel structural abnormalities in the temporoparietal regions of JME patients.…”

Section: Volume Reduction Of the Hippocampus And Thalamus In Jme Patisupporting

confidence: 58%

“…Another recent study using MV in conjunction with neuropsychological testing specifically demonstrated significant hippocampal atrophy that correlated with memory dysfunction in JME patients [42]. This indicates the existence of ictogenic frontotemporal networks and supports the concept of 'system epilepsies' [43].…”

Section: Volume Reduction Of the Hippocampus And Thalamus In Jme Patimentioning

confidence: 62%

Extrafrontal structural changes in juvenile myoclonic epilepsy: A topographic analysis of combined structural and microstructural brain imaging

Kim

Lim

Kim

et al. 2015

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In addition to structural changes in the thalamofrontal system, there was a conspicuous alteration of WM diffusivity in widespread extra-frontal areas and an associated decreased GM thickness in temporoparietal regions, including a significant reduction of hippocampal volume. These findings suggest that the pathophysiology of JME may be not confined to the thalamofrontal circuit but may also involve extensive areas of the extra-frontal network which encompasses temporo-parietal regions.

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“…There are conflicting findings regarding which brain regions are involved and whether the abnormality consists of increased or reduced volume of particular brain regions. Gray matter atrophy in the putamen,3, 4 caudate,4 globus pallidus3 and hippocampus5 has been identified inconsistently across studies in patients with GGE compared to healthy controls. The thalamus has shown the most consistent differences, typically volume loss3, 4, 6, 7 in patients with GGE.…”

Section: Introductionmentioning

confidence: 99%

Thalamic volume reduction in drug‐naive patients with new‐onset genetic generalized epilepsy

et al. 2017

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SummaryObjectivePatients with genetic generalized epilepsy (GGE) have subtle morphologic abnormalities of the brain revealed with magnetic resonance imaging (MRI), particularly in the thalamus. However, it is unclear whether morphologic abnormalities of the brain in GGE are a consequence of repeated seizures over the duration of the disease, or are a consequence of treatment with antiepileptic drugs (AEDs), or are independent of these factors. Therefore, we measured brain morphometry in a cohort of AED‐naive patients with GGE at disease onset. We hypothesize that drug‐naive patients at disease onset have gray matter changes compared to age‐matched healthy controls.MethodsWe performed quantitative measures of gray matter volume in the thalamus, putamen, caudate, pallidum, hippocampus, precuneus, prefrontal cortex, precentral cortex, and cingulate in 29 AED‐naive patients with new‐onset GGE and compared them to 32 age‐matched healthy controls. We subsequently compared the shape of any brain structures found to differ in gray matter volume between the groups.ResultsThe thalamus was the only structure to show reduced gray matter volume in AED‐naive patients with new‐onset GGE compared to healthy controls. Shape analysis revealed that the thalamus showed deflation, which was not uniformly distributed, but particularly affected a circumferential strip involving anterior, superior, posterior, and inferior regions with sparing of medial and lateral regions.SignificanceStructural abnormalities in the thalamus are present at the initial onset of GGE in AED‐naive patients, suggesting that thalamic structural abnormality is an intrinsic feature of GGE and not a consequence of AEDs or disease duration.

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Hippocampal atrophy and memory dysfunction in patients with juvenile myoclonic epilepsy

Cited by 28 publications

References 36 publications

Cognitive performance in juvenile myoclonic epilepsy patients with specific endophenotypes

Cognitive performance in juvenile myoclonic epilepsy patients with specific endophenotypes

Extrafrontal structural changes in juvenile myoclonic epilepsy: A topographic analysis of combined structural and microstructural brain imaging

Thalamic volume reduction in drug‐naive patients with new‐onset genetic generalized epilepsy

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