Hippocampal asymmetry in exploratory behavior to vasoactive intestinal polypeptide

Ivanova, Margarita; Ternianov, Alexandar; Belcheva, S.; Tashev, Roman; Negrev, Negrin; Belcheva, Iren

doi:10.1016/j.peptides.2008.01.016

Cited by 12 publications

(8 citation statements)

References 60 publications

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“…We have previously demonstrated a lateralized VIP effect on the exploratory activity of rats (number of movements in a 5-min period of observation) after administration into hippocampal CA1 area. VIP injection (50 ng and 100 ng) into the right CA1 area stimulated the activity, while that of 100 ng into the left CA1 decreased the number of movements (13). Interestingly, in the present study, the locomotor stimulatory effect was exhibited after VIP injection into the left CA1 area in OBX rats.…”

Section: Discussionsupporting

confidence: 47%

Locomotor responses to vasoactive intestinal peptide in bulbectomized rats

Ivanova

Belcheva

et al. 2013

SSM

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PURPOSE: The present study aimed at studying the effects of vasoactive intestinal peptide (VIP) microinjected unilaterally into the hippocampal CA1 area on the locomotor activity of rats with olfactory bulbectomy. Hippocampus has been chosen as it is a region with high VIP receptor density as well as a brain structure implicated in many types of disorders, including depression. MATERIAL AND METHODS: Olfactory bulbectomy (OBX) rat is among the well-validated animal models of depression. The changes in locomotor activity of OBX rats were registered in an Opto Varimex apparatus. RESULTS: VIP injected into the left CA1 area at doses of 10 ng and 100 ng aggravated OBX rat hyperactivity by increasing the locomotor activity. VIP (in a dose of 100 ng) microinjected into the right CA1 area produced an opposite effect by decreasing the number of both horizontal and vertical movements in OBX rats as compared to saline-treated OBX controls. CONCLUSION: Our data reveal a pronounced lateralized VIP effect on the locomotor activity of OBX rats and point to a possible VIP involvement in the mechanisms of the olfactory bulbectomy syndrome in rats.

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Section: Discussionsupporting

confidence: 47%

Locomotor responses to vasoactive intestinal peptide in bulbectomized rats

Ivanova

Belcheva

et al. 2013

SSM

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“…The relevance of VIP modulation for the above mentioned learning processes may be related to the role of VIP in inhibiting exploration (Ivanova et al, ), and enhancing performance in water‐maze learning tasks (Glowa et al, ). The behavioral consequences of hippocampal actions of VIP described in this work in juvenile and young adult animals surely require further investigation.…”

Section: Discussionmentioning

confidence: 99%

Endogenous inhibition of hippocampal LTD and depotentiation by vasoactive intestinal peptide VPAC₁ receptors

2014

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Vasoactive intestinal peptide (VIP), an important modulator of hippocampal synaptic transmission, influences exploration and hippocampal-dependent learning in rodents. Homosynaptic long-term depression (LTD) and depotentiation are two plasticity phenomena implicated in learning of behavior flexibility and spatial novelty detection. In this study, we investigated the influence of endogenous VIP on LTD and depotentiation induced by low-frequency stimulation (1 Hz, 900 pulses) of the hippocampal CA1 area in vitro in juvenile and young adult rats, respectively. LTD and depotentiation were enhanced by the VIP receptor antagonist Ac-Tyr(1) , D-Phe(2) GRF (1-29), and the selective VPAC1 receptor antagonist, PG 97-269, but not the selective VPAC2 receptor antagonist, PG 99-465. This action was mimicked by an anti-VIP antibody, suggesting that VIP, and not pituitary adenylate cyclase-activating polypeptide (PACAP), is the endogenous mediator of these effects. Selective inhibition of PAC1 receptors with PACAP (6-38) enhanced depotentiation, but not LTD. VPAC1 receptor blockade also revealed LTD in young adult rats, an effect abolished by the GABAA antagonist bicuculline, evidencing an involvement of GABAergic transmission. We conclude that inhibition of LTD and depotentiation by endogenous VIP occurs through VPAC1 receptor-mediated mechanisms and suggest that disinhibition of pyramidal cell dendrites is the most likely physiological mechanism underlying this effect. As such, VPAC1 receptor ligands may be considered promising pharmacological targets for treatment of cognitive dysfunction in diseases involving altered GABAergic circuits and pathological saturation of LTP/LTD like Down's syndrome and temporal lobe epilepsy.

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“…In recent years, our lab has been investigating behavioral asymmetry after administration of neuropeptides in the hippocampal CA1 area. VIP microinjected into the left CA1 area produced a dose-dependent inhibitory effect on exploratory behavior and a stimulatory effect into the right CA1 area (Ivanova et al 2008), while angiotensin II microinjected into the left CA1 area improved learning and memory (Belcheva et al 2000). The injection of 5-HT1A receptor ligands in CA1 area also showed a lateralized effect on learning and memory, more pronounced in the right side (Belcheva et al 2007).…”

Section: Introductionmentioning

confidence: 93%

Lateralized hippocampal effects of vasoactive intestinal peptide on learning and memory in rats in a model of depression

Ivanova

Belcheva

et al. 2011

Psychopharmacology

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Hippocampal asymmetry in exploratory behavior to vasoactive intestinal polypeptide

Cited by 12 publications

References 60 publications

Locomotor responses to vasoactive intestinal peptide in bulbectomized rats

Locomotor responses to vasoactive intestinal peptide in bulbectomized rats

Endogenous inhibition of hippocampal LTD and depotentiation by vasoactive intestinal peptide VPAC₁ receptors

Lateralized hippocampal effects of vasoactive intestinal peptide on learning and memory in rats in a model of depression

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Hippocampal asymmetry in exploratory behavior to vasoactive intestinal polypeptide

Cited by 12 publications

References 60 publications

Locomotor responses to vasoactive intestinal peptide in bulbectomized rats

Locomotor responses to vasoactive intestinal peptide in bulbectomized rats

Endogenous inhibition of hippocampal LTD and depotentiation by vasoactive intestinal peptide VPAC1 receptors

Lateralized hippocampal effects of vasoactive intestinal peptide on learning and memory in rats in a model of depression

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Endogenous inhibition of hippocampal LTD and depotentiation by vasoactive intestinal peptide VPAC₁ receptors