Hippocampal area metabolites relate to severity and cognitive function in obstructive sleep apnea

Bartlett, Delwyn J.; Rae, Caroline; Thompson, Campbell; Byth, Karen; Joffe, David; Enright, Tony; Grunstein, Ron

doi:10.1016/j.sleep.2004.08.004

Cited by 138 publications

(102 citation statements)

References 12 publications

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“…It may explain part of the cognitive dysfunction in apnoeic patients. Cognitive changes occurring in sleep apnoea patients [81][82][83] may be linked to anatomical and functional changes occurring at the level of the brain, specifically at the pre-frontal cortex [84] and hippocampal levels [85,86].…”

Section: Cellular and Molecular Consequences Of Ihmentioning

confidence: 99%

See 1 more Smart Citation

Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives

Lévy¹,

Pépin²,

Arnaud³

et al. 2008

European Respiratory Journal

171

111

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There are three major types of sleep-disordered breathing (SDB) with respect to prevalence and health consequences, i.e. obstructive sleep apnoea syndrome (OSAS), CheyneStokes respiration and central sleep apnoea (CSR-CSA) in chronic heart failure, and obesity hypoventilation syndrome (OHS). In all three conditions, hypoxia appears to affect body functioning in different ways. Most of the molecular and cellular mechanisms that occur in response to SDB-related hypoxia remain unknown.In OSAS, an inflammatory cascade mainly dependent upon intermittent hypoxia has been described. There is a strong interaction between haemodynamic and inflammatory changes in promoting vascular remodelling. Moreover, during OSAS, most organ, tissue or functional impairment is related to the severity of nocturnal hypoxia. CSR-CSA occurring during heart failure is primarily a consequence of cardiac impairment. CSR-CSA has deleterious consequences for cardiac prognosis and mortality since it favours sympathetic activation, ventricular ectopy and atrial fibrillation. Although correction of CSR-CSA seems to be critical, there is a need to establish therapy guidelines in large randomised controlled trials.Finally, OHS is a growing health concern, owing to the worldwide obesity epidemic and OHS morbidities. The pathophysiology of OHS remains largely unknown. However, resistance to leptin, obesity and severe nocturnal hypoxia lead to insulin resistance and endothelial dysfunction. In addition, several adipokines may be triggered by hypoxia and explain, at least in part, OHS morbidity and mortality.Overall, chronic intermittent hypoxia appears to have specific genomic effects that differ notably from continuous hypoxia. Further research is required to fully elucidate the molecular and cellular mechanisms.

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Section: Cellular and Molecular Consequences Of Ihmentioning

confidence: 99%

“…This has been strongly evidenced previously in diabetes and chronic respiratory failure. Assessment of the peripheral nerve in OSA has been made using the usual clinical and neurophysiological indices [86]. There were multiple peripheral nerve anomalies in OSA patients compared to controls.…”

Section: Peripheral Nervementioning

confidence: 99%

Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives

Lévy¹,

Pépin²,

Arnaud³

et al. 2008

European Respiratory Journal

171

111

View full text Add to dashboard Cite

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“…We have found cortical decreases of NAA and the presence of lipids and lactate in anoxic encephalopathy due to status epilepticus with radiological signs of laminar necrosis [23] . In adults we can see interesting findings such as decreased creatine in the hippocampus of patients with sleep apnea [24] . In cardiorespiratory arrest decreases of NAA in cortex and cerebellun may be found with important prognostic value [25] .…”

Section: Hypoxic Encephalopathymentioning

confidence: 91%

Physical Basis of Magnetic Resonance Spectroscopy and its Application to Central Nervous System Diseases

Fayed¹,

Olmos²,

Morales³

et al. 2006

American J. of Applied Sciences

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Magnetic Resonance Spectroscopy is based on the chemical shift property of the atom nuclei when a magnetic field is applied. This technique offers invaluable information about living tissues with special contribution to the diagnosis and prognosis of the central nervous system diseases. Concentration of several metabolites can be assessed in a reproducible manner by means of modern clinical scanners. N-acetyl-aspartate is regarded as a neuronal marker and its levels reflect the neuronal density with significant decreases in degenerative disease such as Alzheimer's disease. Cholinecompounds reflect the cell's membrane turnover and degradation. Myo-inositol has emerged as a glial marker with increases in degenerative diseases. The major usefulness of MRS has been reported in brain tumors, degenerative disorders, myelination defects and encephalopathies. In this review we report the physical basis and the contribution of MR spectroscopy to the diagnosis and prognosis of several diseases of the Central Nervous System.

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“…Neurogliogenesis secondary to IH has also been postulated to occur in patients (58). In a recent study, hypertrophy of the hippocampi of patients with mild OSA was demonstrated, perhaps suggestive of such adaptive processes at work (59), whilst another study identified changes in creatine levels in the hippocampus in OSA patients, suggesting adjusted bioenergetics similar to those seen in ischaemic preconditioning (60).…”

Section: Ihmentioning

confidence: 98%

Emerging co-morbidities of obstructive sleep apnea: cognition, kidney disease, and cancer

Gildeh¹,

Drakatos²,

Higgins³

et al. 2016

J. Thorac. Dis.

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Obstructive sleep apnea (OSA) causes daytime fatigue and sleepiness, and has an established relationship with cardiovascular and metabolic disease. Recent years have seen the emergence of an evidence base linking OSA with an increased risk of degenerative neurological disease and associated cognitive impairment, an accelerated rate of decline in kidney function with an increased risk of clinically significant chronic kidney disease (CKD), and with a significantly higher rate of cancer incidence and death. This review evaluates the evidence base linking OSA with these seemingly unrelated co-morbidities, and explores potential mechanistic links underpinning their development in patients with OSA, including intermittent hypoxia (IH), sleep fragmentation, sympathetic excitation, and immune dysregulation.

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Hippocampal area metabolites relate to severity and cognitive function in obstructive sleep apnea

Cited by 138 publications

References 12 publications

Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives

Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives

Physical Basis of Magnetic Resonance Spectroscopy and its Application to Central Nervous System Diseases

Emerging co-morbidities of obstructive sleep apnea: cognition, kidney disease, and cancer

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