Hippocampal activity, behavior, self-stimulation, and heart rate during electrical stimulation of the lateral hypothalamus.

Iq, Whishaw; Bh, Bland; Ch, Vanderwolf

doi:10.1037/h0032534

Cited by 50 publications

(14 citation statements)

References 23 publications

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“…The lateral hypothalamic region can exert a significant influence over the hippocampal EEG. Electrical stimulation of the same lateral hypothalamic site can elicit different hippocampal EEG patterns with different voltages (Whishaw et al, 1972), evidence that synchronising and desynchronising systems are adjacent in this region, and can be activated in parallel. Similarly, the effects of LH lesions on theta depend on their precise position (Jurkowlaniec et al, 1989).…”

Section: Discussionmentioning

confidence: 99%

Multiple hypothalamic sites control the frequency of hippocampal theta rhythm

et al. 2003

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Stimulation of a neural pathway originating in the brainstem reticular formation, with synapses in the medial hypothalamus, activates the hippocampal theta rhythm. The frequency of reticular-elicited theta is determined in the medial supramammillary nucleus (mSuM) completely in anaesthetised rats, but only partially when the animal is awake. We tested other medial hypothalamic sites for their capacity to control theta frequency in awake rats. Blockade of sodium channels (1 microl fast infusion of the local anaesthetic procaine, experiment 1) or increased inhibition by GABA (Chlordiazepoxide [CDP], experiment 2) was found to reduce or increase the frequency of reticular-elicited theta, depending on the precise site of injection, in the region of the dorsomedial hypothalamic nucleus (DMH) and the posterior hypothalamic nucleus (PH). A band of null sites for CDP was located in the region of the ventral border of PH and dorsal border of mSuM. Using 0.5 and 1 microl CDP, and slow infusions (experiment 3), it was found that effective PH sites were also separate from mSuM in the rostrocaudal direction. In experiment 4, the DMH/PH region was mapped with unilateral and bilateral slow infusions of 0.5 microl CDP. CDP significantly reduced frequency in medial (periventricular) and dorsal PH, but not DMH. Bilateral injections appeared to generally sum the usual effects of unilateral injection, producing effects of intermediate size. However, the absolute frequency change in any given site, or with any pair of sites, did not exceed 1 Hz, which is similar to what is seen with single injections in mSuM. Overall, it appears that at, any one time, theta frequency may be determined by a complex interplay between distinct but interacting modulatory regions in the medial hypothalamus.

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Section: Discussionmentioning

confidence: 99%

Multiple hypothalamic sites control the frequency of hippocampal theta rhythm

et al. 2003

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“…Hippocampal theta has a robust association with voluntary movements (Slawinska & Kasicki, 1998;Kramis, Vanderwolf, & Bland, 1975;Vanderwolf, 1969;Whishaw & Vanderwolf, 1973), including leverpressing (Black & Young, 1972). A number of observationssupport a relationship between movement or movement initiation and theta frequency Morris & Hagan, 1983;Oddie, Stefanek, Kirk, & Bland, 1996;Rivas, Gaztelu, & Garcia-Austt, 1996;Slawinska & Kasicki, 1998;Vanderwolf, 1969;Whishaw, Bland, & Vanderwolf, 1972). In general, higher frequencies are associated with greater initial speed of movements and the preparation for such movements.…”

Section: Discussionmentioning

confidence: 99%

Similar effects of medial supramammillary or systemic injection of chlordiazepoxide on both theta frequency and fixed-interval responding

Woodnorth

McNaughton

2002

Cognitive, Affective, & Behavioral Neuroscience

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“…Paxinos and Bindra (1970), Vanderwolf (1969), and Whishaw and Vanderwolf (1973) report a general correlation between motor activity and theta. Results in Dalton and Black (1968), Vanderwolf (1971), Whishaw et al (1972), Black and Young (1972), and Buzsaki et al (1985) specifically examine and report the observation of theta rhythm during bar presses. Two studies explicitly claim otherwise: both Feder and Ranck (1973) and Coleman and Lindsley (1975) report a very notable lack of theta oscillations during bar presses that have been performed many times, although the latter study was performed on …”

Section: Comparison With Existing Datamentioning

confidence: 96%

Analysis of theta power in hippocampal EEG during bar pressing and running behavior in rats during distinct behavioral contexts

et al. 2004

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These experiments examine changes in theta power as measured by wavelet analysis in five rats performing a conditional visual discrimination task and a simple running task. In the conditional task, rats were trained to press one lever to initiate a trial and then to press one of two choice levers, each corresponding to one of two cue lights. Analysis of theta power in this operant task found a large decrease in theta power during the choice bar presses, in contrast to the increase in theta power during trial initiation bar presses. This result seems to stand counter to results that propose consistent relationships between motor actions and theta power (Vanderwolf, EEG Clin Neurophys 26:407-418, 1969), as well as studies suggesting that the lack of bar-press theta is the result of habituation. However, these data can be seen as being in broad agreement with the theoretical framework of sensorimotor integration (Bland and Oddie, Behav Brain Res 127:119-136, 2001). To investigate further the power of theta observed at the termination of type 1 motor activity, a runway task was devised in which rats ran back and forth between two ends of a linear track, one of which was always rewarded and the other never rewarded. Theta power decreased sharply 240 ms before movement ended at the rewarded end, but not at the unrewarded end of the track. These data extend the current scope of theory in demonstrating that hippocampal theta activity can end abruptly 200-400 ms prior to the end of type 1 motor movement when approaching the end of a motor sequence.

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Hippocampal activity, behavior, self-stimulation, and heart rate during electrical stimulation of the lateral hypothalamus.

Cited by 50 publications

References 23 publications

Multiple hypothalamic sites control the frequency of hippocampal theta rhythm

Multiple hypothalamic sites control the frequency of hippocampal theta rhythm

Similar effects of medial supramammillary or systemic injection of chlordiazepoxide on both theta frequency and fixed-interval responding

Analysis of theta power in hippocampal EEG during bar pressing and running behavior in rats during distinct behavioral contexts

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