2000
DOI: 10.1590/s0037-86822000000600014
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Hipogamaglobulinemia como fator de risco para infecção por Cryptococcus neoformans: a propósito de dois casos

Abstract: Resumo Dois pacientes HIV-soronegativos com doença criptocócica refratária à terapia antifúngica convencional foram submetidos a estudo do sistema imune. Hipogamaglobulinemia foi evidenciada em ambos e associada à alteração funcional da imunidade mediada por células. Hipogamaglobulinemia é considerada como um possível fator predisponente para infecção criptocócica. A importância dos anticorpos no controle da infecção por Cryptococcus neoformans é discutida. Palavras-chaves: Hipogamaglobulinemia. Cryptococcus n… Show more

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Cited by 9 publications
(2 citation statements)
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“…After reviewing the literature, the use of immunosuppressive drugs, such as mycophenolate mofetil, was reported to suppress AIDS humoral immunity and lead to either the absence of or a low titre of HIV antibodies, which cannot be detected [15]. In patients with diseases that result in low humoral immunity levels, such as those complicated with hypogammaglobulinemia, the HIV antibody is undetectable [16]. HIV-specific helper T-cells are T-cells labelled by CD4 + .…”
Section: Discussionmentioning
confidence: 99%
“…After reviewing the literature, the use of immunosuppressive drugs, such as mycophenolate mofetil, was reported to suppress AIDS humoral immunity and lead to either the absence of or a low titre of HIV antibodies, which cannot be detected [15]. In patients with diseases that result in low humoral immunity levels, such as those complicated with hypogammaglobulinemia, the HIV antibody is undetectable [16]. HIV-specific helper T-cells are T-cells labelled by CD4 + .…”
Section: Discussionmentioning
confidence: 99%
“…However, in addition to T cell deficiencies, B cell deficits and hypogammaglobulinemia [ 70 , 71 , 72 ] have also been linked to cryptococcal illness [ 73 ] in patients. In addition, IgG2 deficiency has been found in healthy subjects with C. gattii meningitis [ 74 ], and in adults and children with HIV/AIDS with specific levels of IgG2, the polysaccharide glucuronoxylomannan (GXM) was lower than those without the disease [ 75 , 76 ].…”
Section: Antibodies Against Fungal Infectionmentioning
confidence: 99%