Hipertiroidismo neonatal transitório

Jerónimo, Mónica; Moinho, Rita; Vicente, Inês Nunes; Oliveira, A. Carvalho Antunes De; Dias, Andrea; Mimoso, Gabriela; Dinis, Isabel; Mirante, Alice; Faria, Dolores

doi:10.1016/j.rpedm.2014.07.006

Cited by 1 publication

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 Although our Pediatric Endocrinology Unit published a protocol for evaluation of these offspring in 2014, there were nine cases without blood cord analysis afterwards, and in four cases it lacked all the required determinations (TSH, fT4, fT3 and TRAb). 8 This emphasises the need for improving communication between pediatricians and obstetricians. The need for experienced multidisciplinary teams has been endorsed by various authors; for Léger, they should be comprised of adult and pediatric endocrinologists, obste-tricians and fetal radiologists.…”

Section: Discussionmentioning

confidence: 99%

“…5,7 Neonatal hyperthyroidism occurs in 2% of the offspring of mothers with GD, and although it is usually transitory, it can be life-threatening, with the need for admission to the intensive care unit. 8,9 Hypothyroidism is usually transitory, and it represents around 2% of cases of congenital hypothyroidisms. 1 It is important to remember that ATD pass through the placenta, and, therefore, can delay the presentation of hyperthyroidism, or even induce temporary hypothyroidism.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neonates Born to Mothers with Graves’ Disease: 15 Year Experience of a Pediatric Endocrinology Department

Luz¹,

Martins²,

Jerónimo³

et al. 2020

Acta Med Port

Self Cite

View full text Add to dashboard Cite

Introduction: Graves disease is characterized by the existence of autoantibodies directed to the thyrotropin receptor, which can have a stimulatory/inhibitory action, in women with the condition, their fetus or neonate. Our aim was to review the case series of these neonates in order to establish neonatal thyroid function predictors.Material and Methods: Retrospective cohort study of the database of the Department of Pediatric Endocrinology, including patients born to mothers with Graves’ disease, between 2002 and 2017. Clinical and biochemical data were collected from mothers and offspring.Results: Fifty newborns, from 46 women with a median of 3.5 years after diagnosis, were included. During all trimesters of pregnancy, more than half of women had positive autoantibodies directed to the thyrotropin receptor. Not every woman had a complete thyroid function evaluation every trimester. In 32 newborns, cord blood screening was done. During the neonatal period, there were three cases of hypothyroidism and two of hyperthyroidism. The mothers of these five newborns had higher levels of free thyroid hormones during the second trimester (p = 0.03). The level of antibodies directed to the thyrotropin receptor was significantly higher in the cord blood (p = 0.03) and in the first neonatal test (p = 0.03) of these dysthyroid newborns.Discussion: Our results reinforce the need for every pregnant woman with Graves’ disease to be subject to thyroid function and autoantibodies evaluation during every trimester, as well as the importance of evaluating these antibodies in cord blood.Conclusion: High levels of free thyroid hormones during the second trimester of pregnancy and antibodies directed to the thyrotropin receptor value in cord blood are predictors of dysthyroidism in neonates born from women with Grave’s disease.

show abstract

Section: Discussionmentioning

confidence: 99%