Hipersensibilidade auditiva no transtorno do espectro autístico

Gomes, Erissandra; Pedroso, Fleming Salvador; Wagner, Mário Bernardes

doi:10.1590/s0104-56872008000400013

Cited by 110 publications

(46 citation statements)

References 24 publications

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“…Electrical stapedial reflex thresholds (ESRT), neural response telemetry (NRT), neural response imaging (NRI), and automated response telemetry (ART) may be used for programming when a behavioral response is not obtainable. However, programming should proceed conservatively since children with ASD may be prone to hyperacusis 21 . We did not find this to be a particularly troublesome issue with our patients.…”

Section: Discussionmentioning

confidence: 99%

Cochlear Implantation in Children With Autism Spectrum Disorder

Eshraghi

Nazarian

Telischi

et al. 2015

Otology &Amp; Neurotology

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Objective To assess the outcome of cochlear implantation in children with Autism Spectrum Disorder Study Design Retrospective case review and survey Setting Tertiary referral center Patients Children who meet criteria for cochlear implantation and diagnosis of Autism Spectrum Disorder Main Outcome Measures Receptive and expressive language scores and parental survey data. Results 15 patients with history of ASD and cochlear implantation were analyzed and compared to 15 patients who received cochlear implant and have no other disability. Post-operatively, more than 67% of children with ASD significantly improved their speech perception skills and 60% significantly improved their speech expression skills while all patients in the control group showed significant improvement in both aspects. The top three reported improvements after cochlear implantation were name recognition, response to verbal requests, and enjoyment of music. Of all behavioral aspects, the use of eye contact was the least improved. Survey results in regards to improvements in patient interaction were more subtle when compared to those related to sound and speech perception. The most improved aspects in the ASD patients’ lives after cochlear implantation appeared to be attending to other people’s requests and conforming to family routines. Of note, awareness of the child’s environment is the most highly ranked improvement attributed to the cochlear implant. Conclusions Cochlear implants are effective and beneficial for hearing impaired members of the ASD population even though development of language may lag behind that of implanted children with no additional disabilities. Significant speech perception and overall behavior improvement are noted.

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Section: Discussionmentioning

confidence: 99%

Cochlear Implantation in Children With Autism Spectrum Disorder

Eshraghi

Nazarian

Telischi

et al. 2015

Otology &Amp; Neurotology

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“…Additionally, autistic individuals usually present excessive reactions to the sensory environment such as aversive reactions to visual, auditory, and tactile stimuli. These perception and sensory reactivity abnormalities are found in majority of subjects with ASD affecting their ability to effectively process information (Gomes et al, 2008). In a series of electrophysiological studies conducted by our group we explored specifics of event-related potential (i.e., ERP) reflecting information processing during performance on reaction time (RT) tasks in children with ASD (Sokhadze et al, 2009a, 2012b, 2013a; Baruth et al, 2010c; Casanova et al, 2012) Our studies were aimed to explore the manifestations of the impaired functional connectivity, excessive cortical excitation/inhibition ratio, and deficient executive functioning in ASD by analyzing behavioral performance on attention tasks with dense-array ERP recording.…”

Section: Introductionmentioning

confidence: 99%

rTMS neuromodulation improves electrocortical functional measures of information processing and behavioral responses in autism

Sokhadze

El-Baz

Sears

et al. 2014

Front. Syst. Neurosci.

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Objectives: Reports in autism spectrum disorders (ASD) of a minicolumnopathy with consequent deficits of lateral inhibition help explain observed behavioral and executive dysfunctions. We propose that neuromodulation based on low frequency repetitive Transcranial Magnetic Stimulation (rTMS) will enhance lateral inhibition through activation of inhibitory double bouquet interneurons and will be accompanied by improvements in the prefrontal executive functions. In addition we proposed that rTMS will improve cortical excitation/inhibition ratio and result in changes manifested in event-related potential (ERP) recorded during cognitive tests.Materials and Methods: Along with traditional clinical behavioral evaluations the current study used ERPs in a visual oddball task with illusory figures. We compared clinical, behavioral and electrocortical outcomes in two groups of children with autism (TMS, wait-list group). We predicted that 18 session long course in autistic patients will have better behavioral and ERP outcomes as compared to age- and IQ-matched WTL group. We used 18 sessions of 1 Hz rTMS applied over the dorso-lateral prefrontal cortex in 27 individuals with ASD diagnosis. The WTL group was comprised of 27 age-matched subjects with ASD tested twice. Both TMS and WTL groups were assessed at the baseline and after completion of 18 weekly sessions of rTMS (or wait period) using clinical behavioral questionnaires and during performance on visual oddball task with Kanizsa illusory figures.Results: Post-TMS evaluations showed decreased irritability and hyperactivity on the Aberrant Behavior Checklist (ABC), and decreased stereotypic behaviors on the Repetitive Behavior Scale (RBS-R). Following rTMS course we found decreased amplitude and prolonged latency in the frontal and fronto-central N100, N200 and P300 (P3a) ERPs to non-targets in active TMS treatment group. TMS resulted in increase of P2d (P2a to targets minus P2a to non-targets) amplitude. These ERP changes along with increased centro-parietal P100 and P300 (P3b) to targets are indicative of more efficient processing of information post-TMS treatment. Another important finding was decrease of the latency and increase of negativity of error-related negativity (ERN) during commission errors that may reflect improvement in error monitoring and correction function. Enhanced information processing was also manifested in lower error rate. In addition we calculated normative post-error treaction time (RT) slowing response in both groups and found that rTMS treatment was accompanied by post-error RT slowing and higher accuracy of responses, whereas the WTL group kept on showing typical for ASD post-error RT speeding and higher commission and omission error rates.Conclusion: Results from our study indicate that rTMS improves executive functioning in ASD as evidenced by normalization of ERP responses and behavioral reactions (RT, accuracy) during executive function test, and also by improvements in clinical evaluations.

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“…Perception and sensory reactivity abnormalities are found in majority of subjects with ASD affecting their ability to effectively process information (Gomes et al 2008). In a series of electrophysiological studies conducted by our group we explored specifics of event-related potentials (i.e., ERP) reflecting information processing during performance on reaction time tasks in children with ASD ( Baruth et al 2010c ; Casanova et al 2012; Sokhadze et al 2009ab, 2012b, 2013a ).…”

Section: Introductionmentioning

confidence: 99%

Neuromodulation Integrating rTMS and Neurofeedback for the Treatment of Autism Spectrum Disorder: An Exploratory Study

Sokhadze

El-Baz

Tasman

et al. 2014

Appl Psychophysiol Biofeedback

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Autism spectrum disorder (ASD) is a pervasive developmental disorder characterized by deficits in social interaction, language, stereotyped behaviors, and restricted range of interests. In previous studies low frequency repetitive transcranial magnetic stimulation (rTMS) has been used, with positive behavioral and electrophysiological results, for the experimental treatment in ASD. In this study we combined prefrontal rTMS sessions with electroencephalographic (EEG) neurofeedback (NFB) to prolong and reinforce TMS-induced EEG changes. The pilot trial recruited 42 children with ASD (~14.5 yrs). Outcome measures included behavioral evaluations and reaction time test with event-related potential (ERP) recording. For the main goal of this exploratory study we used rTMS-neurofeedback combination (TMS-NFB, N=20) and waitlist (WTL, N=22) groups to examine effects of 18 sessions of integrated rTMS-NFB treatment or wait period) on behavioral responses, stimulus and response-locked ERPs, and other functional and clinical outcomes. The underlying hypothesis was that combined TMS-NFB will improve executive functions in autistic patients as compared to the waitlist group. Behavioral and ERP outcomes were collected in preand post-treatment tests in both groups. Results of the study supported our hypothesis by demonstration of positive effects of combined TMS-NFB neurotherapy in active treatment group as compared to control waitlist group, as the TMS-NFB group showed significant improvements in behavioral and functional outcomes as compared to the waitlist group.

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Hipersensibilidade auditiva no transtorno do espectro autístico

Cited by 110 publications

References 24 publications

Cochlear Implantation in Children With Autism Spectrum Disorder

Cochlear Implantation in Children With Autism Spectrum Disorder

rTMS neuromodulation improves electrocortical functional measures of information processing and behavioral responses in autism

Neuromodulation Integrating rTMS and Neurofeedback for the Treatment of Autism Spectrum Disorder: An Exploratory Study

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