Hip arthroplasties in Gaucherʼs disease.

lau, Miguel; Lichtman, David M.; Hamati, Y I; Bierbaum, Benjamin E.

doi:10.2106/00004623-198163040-00009

Cited by 17 publications

(9 citation statements)

References 0 publications

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“…Historically high early failure rates were reported, and this was attributed to the abnormal and deteriorating bone matrix into which the implant was inserted. Aseptic loosening rates ranged from 13-57% at 5-7 years (9)(10)(11)(17)(18)(19)(20). In addition, high intraoperative blood loss and higher than normal post-operative infection rates were also documented (20,21).…”

Section: Total Hip Replacement and Survivalmentioning

confidence: 99%

“…Patients are typically young with significant morbidity, and total hip replacement (THR) may be required. The historical results of THR in patients with GD have been poor with high rates of aseptic loosening and peri-operative complications (9)(10)(11). We present a series of twelve THRs (eleven conventional THRs and one hip resurfacing) in nine patients.…”

Section: Introductionmentioning

confidence: 99%

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Gaucher Disease: Outcome following Total Hip Replacements and Effect of Enzyme Replacement Therapy in a Cohort of Uk Patients

et al. 2011

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Only a limited number of reports of total hip replacements (THRs) in patients with Gaucher disease (GD) have been published, with the majority showing high rates of early aseptic loosening as well as an increased number of peri-operative complications. We present a series of twelve THRs in nine affected patients, with a mean age of 39 years at the time of surgery (median 37 years; range 27-60 years). We examine the medium- to long-term results and present the outcome scores, survival, and assess the effect of enzyme replacement therapy (ERT). Four hips (33.3%) required revision for aseptic loosening at a mean time of 11.5 years. There was no significant difference in survival between the group on ERT at the time of surgery and group not on ERT. Those on ERT did, however, have fewer peri-operative complications and there was a trend to better outcome scores. Five of the 12 THRs were performed when the diagnosis of GD was unknown and all of these had early complications.?Our results show better survival of THRs in patients with GD than previously thought. The use of ERT pre-operatively did not have an effect on survival, nor outcome scores, but did reduce the peri-operative complication rate. Those not on ERT at the time of surgery were commenced on it at some point in their treatment (at an average of 8.6 years following THR) and we believe the use of ERT, at any time in the treatment, could have contributed to the improved survival seen in our series compared to historical results in the literature.

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Section: Total Hip Replacement and Survivalmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gaucher Disease: Outcome following Total Hip Replacements and Effect of Enzyme Replacement Therapy in a Cohort of Uk Patients

et al. 2011

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“…20,21 Early studies raised concern regarding the long-term success of total hip arthroplasty in patients with osteonecrosis secondary to Gaucher disease. One study of 15 THAs in 8 patients did reveal 73% implant survivorship with good outcomes at an average 14-year follow up using primarily the Charnley prosthesis.…”

Section: Gaucher Diseasementioning

confidence: 99%

Total Hip Replacement in Osteonecrosis

Nelson

Israelite

Garino

2008

Techniques in Orthopaedics

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“…(7) In our case, we chose to use amoxicillin for prophylaxis and cephalexin in the postoperative period to control infection and our results were good about two weeks after the extraction.…”

mentioning

confidence: 96%