HIO3/KI: A new combination reagent for iodination of aromatic amines and trimethylsilylation of alcohols and phenols through in situ generation of iodine under mild conditions

Abstract

A combination of iodic acid and potassium iodide has been used for trimethylsilylation of alcohols and phenols in the presence of HMDS and iodination of aromatic amines. The reactions occur very rapidly to provide the products in good to high yields in dichloromethane at room temperature while the use of toxic and corrosive molecular iodine is avoided.