Hintonia latiflora bei Typ-2-Diabetes - Klinische Langzeitstudie

Korecova, Marta; Hladícova, Marie; Korec, R

doi:10.1055/s-2007-967719

Cited by 7 publications

(5 citation statements)

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“…However, the extent of the observed improvement is unlikely to be reached by vitamins and trace elements alone. A comparable effect was previously achieved with the long-term administration of extract from the bark of Hintonia latiflora in human beings without the addition of other micronutrients [14], which confirms the nutritional physiological importance of the plant preparation. Furthermore, positive effects on the regulation of the blood glucose balance could also be experimentally verified and attributed to the polyphenolic fraction [8].…”

Section: Discussionsupporting

confidence: 79%

“…Normalizations of diabetic parameters, with the absence of hypoglycemic episodes, have been observed upon exposure to Hintonia extracts [9-13]. In a long-term study lasting up to 33 months, the mean HbA 1c value of the participants decreased below the target value of 7% after six months of consumption of a liquid extract from the bark of Hintonia latiflora , with excellent tolerance [14]. …”

Section: Introductionmentioning

confidence: 99%

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Treatment of mild and moderate type-2 diabetes: open prospective trial with Hintonia latiflora extract

Korecova¹,

Hladíková

2014

Eur J Med Res

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BackgroundExtracts from the bark of Hintonia latiflora are used as dietetic measures to support the regulation of glucose metabolism and the stabilization of blood glucose values.MethodsA dry concentrated extract from the bark of Hintonia latiflora in capsule form was tested in an open, prospective clinical study in 41 dietetically stabilized subjects with type 2 diabetes. The effects on parameters of blood glucose control were documented over a period of six months.ResultsFasting and postprandial glucose and the HbA1c value declined significantly. In the case of HbA1c, this meant a reduction of the absolute value from 7.49 ± 0.72% to 6.82 ± 0.67% (from 58.4 to 51.0 mmol/mol Hb; intention to treat (ITT) population). Furthermore, cholesterol and triglycerides were slightly reduced and no negative effect on other laboratory parameters and no change of the liver values were observed. Tolerance was very good. In particular, no side effects and no hypoglycemic episodes or worsening of diabetic symptoms occurred.ConclusionsThe study confirms the positive effect of extracts from the bark of Hintonia latiflora on blood glucose values suggesting a potential benefit in the management of glucose metabolism in cases of type 2 diabetes.Trial registrationReg.-No. ISRCTN83308122

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Treatment of mild and moderate type-2 diabetes: open prospective trial with Hintonia latiflora extract

Korecova¹,

Hladíková

2014

Eur J Med Res

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“…There were no hypoglycemic episodes or adverse events throughout the total treatment period. The product manufacturer sponsored this clinical study …”

Section: From Plants To α-Glucosidase Inhibitorsmentioning

confidence: 99%

Mexican Antidiabetic Herbs: Valuable Sources of Inhibitors of α-Glucosidases

et al. 2013

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Type II-diabetes mellitus (TII-DM) has been regarded as one of the most important public health problems in all nations in the 21st century. Although allopathic therapies remain the most important for the initial management of TII-DM, herbal remedies have gained wide acceptance for treating this condition. These alternative therapies are particularly valued in countries such as Mexico, rich in medicinal plants strongly attached to the cultural values of the population. Medicinal plants are prized sources of α-glucosidase inhibitors, which delay the liberation of glucose from complex carbohydrates, retarding glucose absorption, and thus controlling the characteristic hyperglycemia of TII-DM. Among the plant species used for treating diabetes in Mexico only 38 have been analyzed for their inhibitory activity of α-glucosidases. Most of these studies, reviewed in the present work, have focused on the evaluation of different types of extracts on the activity of α-glucosidases from diverse sources. Four species have been thoroughly analyzed in order to discover novel α-glucosidase inhibitors, namely, Hintonia latiflora and Hintonia standleyana (Rubiaceae), Ligusticum porteri (Apiaceae), and Brickellia cavanillesii (Asteraceae). Their ethnomedical uses, pharmacological and toxicological studies, chemical composition, and antihyperglycemic principles with α-glucosidase inhibitory activity are summarized.

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“…et Schult., and E. mexicanum Gray are the most widely used species. The chemical composition − as well as the antidiabetic, ,,− antimalarial, , and antimicrobial properties of the stem bark of H. latiflora have been the subject of several investigations. More recently, we have described the antidiabetic and antinociceptive properties as well as some chemical constituents of H. standleyana stem bark. , In the last 50 years, the stem bark of both these Hintonia species has been exploited extensively and commercialized, locally and outside of Mexico, without any official regulation.…”

mentioning

confidence: 99%

“…et Schult., and E. mexicanum Gray are the most widely used species. The chemical composition [6][7][8][9][10][11] as well as the antidiabetic, 3,4,[11][12][13][14][15] antimalarial, 10,16 and antimicrobial 17 properties of the stem bark of H. latiflora have been the subject of several investigations. More recently, we have described the antidiabetic and antinociceptive properties as well as some chemical constituents of H. standleyana stem bark.…”

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confidence: 99%

Hypoglycemic Activity of Extracts and Compounds from the Leaves of Hintonia standleyana and H. latiflora: Potential Alternatives to the Use of the Stem Bark of These Species^,

et al. 2009

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The CH(2)Cl(2)-MeOH (1:1) extract of the leaves of Hintonia standleyana and H. latiflora caused significant decrease in blood glucose levels in both normal and streptozotozin (STZ)-induced diabetic rats when compared with vehicle-treated groups (p < 0.05). These extracts were not toxic to mice according to the Lorke criteria. From the hypoglycemic extract of H. standleyana, two new 4-phenylcoumarins, namely, 6''-O-acetyl-5-O-beta-d-galactopyranosyl-7,4'-dihydroxy-4-phenylcoumarin (1) and 6''-O-acetyl-5-O-beta-d-galactopyranosyl-7,3',4'-trihydroxy-4-phenylcoumarin (2), were obtained. The analogous extract of H. latiflora yielded the new 5-O-[beta-d-xylopyranosyl-(1-->6)-beta-d-glucopyranosyl]-7,4'-dimethoxy-4-phenylcoumarin (3) along with several known compounds, including ursolic acid and desoxycordifolinic acid. Phenylcoumarins 1 and 2 showed hypoglycemic activity. HPLC profiles of the leaf extracts of both plants revealed the presence of known hypoglycemic phenylcoumarins as well as chlorogenic acid. The overall results have indicated that the leaves of H. standleyana and H. latiflora possess similar antidiabetic potential to their stem bark. Therefore, the leaves from these species could represent an alternative to the use of their stem bark, which, in turn, would contribute to the conservation of these Mexican medicinal plants.

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Hintonia latiflora bei Typ-2-Diabetes - Klinische Langzeitstudie

Cited by 7 publications

References 1 publication

Treatment of mild and moderate type-2 diabetes: open prospective trial with Hintonia latiflora extract

Treatment of mild and moderate type-2 diabetes: open prospective trial with Hintonia latiflora extract

Mexican Antidiabetic Herbs: Valuable Sources of Inhibitors of α-Glucosidases

Hypoglycemic Activity of Extracts and Compounds from the Leaves of Hintonia standleyana and H. latiflora: Potential Alternatives to the Use of the Stem Bark of These Species^,

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Hintonia latiflora bei Typ-2-Diabetes - Klinische Langzeitstudie

Cited by 7 publications

References 1 publication

Treatment of mild and moderate type-2 diabetes: open prospective trial with Hintonia latiflora extract

Treatment of mild and moderate type-2 diabetes: open prospective trial with Hintonia latiflora extract

Mexican Antidiabetic Herbs: Valuable Sources of Inhibitors of α-Glucosidases

Hypoglycemic Activity of Extracts and Compounds from the Leaves of Hintonia standleyana and H. latiflora: Potential Alternatives to the Use of the Stem Bark of These Species,

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Hypoglycemic Activity of Extracts and Compounds from the Leaves of Hintonia standleyana and H. latiflora: Potential Alternatives to the Use of the Stem Bark of These Species^,