Hinokitiol Inhibits Candida albicans Adherence to Oral Epithelial Cells

Nakamura, Moriyuki; Fujibayashi, Taisuke; Tominaga, Akira; Satoh, Norifumi; Kawarai, Taketo; Shinozuka, Osamu; Watanabe, Haruo; Yamazaki, T.; Senpuku, Hidenobu

doi:10.1016/s1349-0079(10)80007-6

Cited by 5 publications

(2 citation statements)

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“…In fact, steroid application is not typically the first-choice treatment for stomatitis. However, this admixture paste contains hinokitiol, the active ingredient in Refrecare H®, which has been shown to exert anti-microbial activity against Candida and to inhibit biofilm formation [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

New paste for severe stomatitis in patients undergoing head-and-neck cancer radiotherapy and/or chemotherapy with oral appliance

et al. 2018

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BackgroundThe aim of the present study was to evaluate the physical properties of “admixture paste”, which is a commercially available gel containing hinokitiol for use against severe stomatitis, and its characteristics as a moisturizing gel and denture adhesive.MethodsThe admixture paste, which contained dexamethasone (Dexaltin®), gel for oral care (Refrecare H®) and petrolatum, and its 3 components, either alone or in different combinations, were subjected to viscosity, adhesiveness and elution testing to compare their physical properties. Viscosity was measured with a stress-controlled rheometer. Adhesive force was measured by tension test. Elution under a simulated oral environment was evaluated by monitoring with a fixed-point camera and absorbance. Both adhesiveness and elution were evaluated every hour for 6 h. A linear mixed-effects model was used to assess differences in the time course of elution between samples. In 3 og-rank test was used to compare time to elution into saliva among samples.ResultsThe results of viscosity testing demonstrated that the admixture paste had similar viscosity to cream-type denture adhesives and this was temperature independent. In the adhesiveness tests, the admixture paste showed stronger adhesiveness than that of cream-type denture adhesives. In the elution test, the admixture paste demonstrated gradual dissolution and apparent temporal changes for 6 h in a simulated oral environment.ConclusionsThe results of the present study demonstrated that the admixture paste has adhesive force similar to those of denture adhesives and good local retention in saliva, and that it might be suitable for therapeutic use in patients with severe stomatitis derived from radiotherapy and/or chemotherapy for cancer.Electronic supplementary materialThe online version of this article (10.1186/s12885-018-4017-2) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

New paste for severe stomatitis in patients undergoing head-and-neck cancer radiotherapy and/or chemotherapy with oral appliance

et al. 2018

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“…Hinokitiol, a tropolone monoterpene isolated from cupressaceous plants, exhibits diverse pharmacological effects, such as anti-inflammatory, antioxidant, antitumor and antimicrobial activities [6] , [7] , [8] , [9] . Hinokitiol has been used in food preservation and has excellent biological safety, with low cytotoxicity towards many normal human cell lines, such as human pulp cells, oral epithelial cells and vascular smooth muscle cells, and low chronic toxicity in vivo [9] , [10] , [11] , [12] , [13] . Hinokitiol has been suggested to inhibit the growth and virulence factors of Candida species by regulating the Ras1-cAMP-PKA pathway and transcription factors associated with hyphal formation [14] , but the exact molecular mechanisms of the antifungal action of hinokitiol remain elusive.…”

Section: Introductionmentioning

confidence: 99%