Abstract:BACKGROUND AND PURPOSE Motor deficits after traumatic brain injury (TBI) remain poorly understood. In animals, a localized unilateral brain injury produces hindlimb postural asymmetry (HL-PA) that correlates with contralesional motor impairment. Here we evaluate if a unilateral injury to the sensorimotor cortex by the controlled cortical impact (CCI), a model of clinical focal TBI induces HL-PA in rats, and if this asymmetry is spinally encoded and mediated by the opioid system. EXPERIMENTAL APPROACH HL-PA was… Show more
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