Rate constants obtained from total line-shape analysis of 11 temperature-dependent gas-phase NMR
spectra of (15N)trifluoroacetamide yielded the following kinetic parameters: ΔG
⧧
298 = 15.1(0.36) kcal mol-1,
ΔH
⧧ = 13.3(1.3) kcal mol-1, and ΔS
⧧ = −5.9(4.5) cal mol-1 K-1. Ab initio calculations performed at the
MP2 level using the 6-311++G(d,p) basis set calculated ΔG
⧧
298 = 15.19 kcal mol-1, ΔH
⧧ = 14.35 kcal
mol-1, and ΔS
⧧ = −2.82 cal mol-1 K-1 in reasonable agreement with experiment. Hartree−Fock calculations
using that basis set were also in reasonable agreement with experiment, yielding ΔG
⧧
298 = 16.03 kcal mol-1,
ΔH
⧧ = 14.35 kcal mol-1, and ΔS
⧧ = −5.62 cal mol-1 K-1. DFT calculations (B3-PW91) using the same basis
set gave results that were considerably less accurate.