Himatanthus Willd. ex Schult. (Apocynaceae): Review

Soares, Fabiana Pereira; Cavalcante, Larissa F; Romero, Nirla Rodrigues; Bandeira, M. A. M.

doi:10.4103/0973-7847.176549

Cited by 11 publications

(10 citation statements)

References 34 publications

(32 reference statements)

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“…A presença desses metabólitos também foi relatada no látex e nas folhas de H. drasticus como os possíveis responsáveis pelo efeito cicatrizante e pela ação antiinflamatória, que é regulada pelo Fator de Necrose Tumoral (TNF-alfa) e pela Interleucina 2 (IL2) (Vieira, 2018). Esses metabólitos apresentam diversas atividades farmacológicas, como angiogênicas, anti-inflamatórias, antioxidantes, que aumentam a diferenciação celular e cicatrização das folhas de H. drasticus (Soares et al, 2016). Os metabólitos das folhas de H. obovatus provavelmente aumentaram a migração e a proliferação de células inflamatórias, pela regulação de citocinas e fatores de crescimento no processo de cicatrização, como demonstrado por Cooper (2015) em seu modelo de cicatrização de ferida.…”

Section: Discussionunclassified

“…As diferentes partes da H. drasticus como as folhas, as raizes e o caule são responsáveis pela produção de metabólitos como lupeol e triterpenos que exercem efeito cicatrizante e anti-inflamatório em feridas tegumentar, sendo regulada pelo Fator de Necrose Tumoral (TNF-alfa) e pela Interleucina 2 (IL2) (Vieira, 2018). Além desses metabólitos, os iridoides que também estão presentes em H. drascticus e H. obovatus, inclusive nas folhas, apresentam diversas atividades farmacológicas, como angiogênicas, anti-inflamatórias e antioxidantes, aumentando a diferenciação celular promovendo a cicatrização (Soares et al, 2016). Os iridoides tendem a aumentar a migração e a proliferação de células inflamatórias, regulada por citocinas e fatores de crescimento estando presentes em diversos medicamentos de uso popular com ação sedativa, antitérmica, hipertensiva e cicatrizante (Moragas, 2006).…”

Section: Introductionunclassified

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O efeito cicatrizante do extrato etanólico das folhas de Himatanthus obovatus (Müll Arg.) Woodson

Santos

Almeida

Alves

et al. 2021

RSD

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Himatanthus obovatus, conhecida como janaguba, é encontrada no Nordeste brasileiro. As suas folhas são usadas para hipertensão, manchas na pele e como antitumoral, no entanto ainda são incipientes os estudos quanto à ação cicatrizante. O estudo teve como objetivo analisar o perfil fitoquímico e o efeito cicatrizante do extrato etanólico das folhas de H. obovatus em camundongos. A prospecção fitoquímica do extrato foi realizada pelo teste colorimétrico. Os geis (carbopol mais o extrato) foram confeccionados obtendo as doses de 50, 75 e 100 mg/Kg. O carbopol, água destilada, pomada Nebacetin® e o extrato (gel) foram aplicados de forma tópica na área da lesão dos camundongos como controle negativo (CN), solvente (CS), positivo (CP) e grupo tratamento, respectivamente, durante 21 dias. As feridas foram registradas nos dias 0, 7, 14 e 21 dias para análise macroscópica e histológica após 21 dias. Os dados foram analisados pelo teste de Kruskal-Wallis ou Tukey (p < 0,05). Os resultados mostraram a presença de taninos, açúcares redutores, fenóis, flavonoides e alcaloides. No intergrupo, o extrato não apresentou diferença significativa da área da lesão quando comparado com o CP após o 14° (50 e 75 mg/kg) e 21º dias para todas as doses. No intragrupo, todas as doses do extrato apresentaram redução após o 14° e no 21° para 100 mg/Kg. O extrato mostrou aumento significativo de fibroblastos e área de colágeno em 50 e 100 mg/Kg. Sendo assim, o extrato apresenta potencial para ser explorado como um fitoterápico que possa ser utilizado como gel cicatrizante.

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Section: Discussionunclassified

Section: Introductionunclassified

O efeito cicatrizante do extrato etanólico das folhas de Himatanthus obovatus (Müll Arg.) Woodson

Santos

Almeida

Alves

et al. 2021

RSD

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“…ex Schult. (Apocynaceae) is a genus comprising about 13 species of trees and shrubs, and these are widely distributed in Central and South America, particularly in Brazil [ 3 ]. Triterpenes, alkaloids, flavonoids, and iridoids are the most common chemical compounds found in its leaves, bark, and latex, and these have been shown to have anticancer, anti-inflammatory, and anthelmintic properties.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening of Himatanthus sucuuba (Spruce) Woodson (Apocynaceae) Latex, In Vitro Cytotoxicity and Incision Wound Repair in Mice

Herrera-Calderón

Calero-Armijos

Cardona‐G

et al. 2021

Plants

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Himatanthus sucuuba, also known as “Bellaco caspi”, is a medicinal plant whose latex, stem bark, and leaves possess phenolic acids, lupeol, β-dihydro-plumbericinic acid, plumericin, and plumeride, among other components. Some of these have been linked to such biological activities as antiulcer, anti-inflammatory, and wound healing. The aim of this study was to determine the phytochemical compounds of H. sucuuba latex, as well as its in vitro cytotoxicity and wound healing effect in mice. Latex was collected in the province of Iquitos, Peru. Phytochemical analysis was carried out with UPLC-ESI-MS/MS. The cytotoxicity was evaluated on two colon tumor cell lines (SW480 and SW620) and non-malignant cells (human keratinocytes, HaCaT, and Chinese hamster ovary, CHO-K1). The mice were distributed into two groups, as follows: Group I—control (n = 10; without treatment); II—(n = 10) H. sucuuba latex; wounds were induced with a scalpel in the dorsal–cervical area and treatments were applied topically twice a day on the incision for 10 days. Molecular docking was carried out on the glycogen synthase kinase 3β protein. Twenty-four chemical compounds were determined, mainly flavonoid-type compounds. Latex did not have a cytotoxic effect on tumor cells with IC50 values of more than 500 µg/mL. The latex had a regenerative effect on wounds in mice. Acacetin-7-O-neohesperidoside had the best docking score of -9.9 kcal/mol. In conclusion, H. sucuuba latex had a wound healing effect in mice, as confirmed by histological study. However, a non-cytotoxic effect was observed on colon tumor cells SW480 and SW620.

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“…The pharmacological potential of the species has been demonstrated in different in vivo and in vitro pre-clinical studies, pointing to the presence of anti-inflammatory, antinociceptive, antitumor, and gastroprotective actions in the latex, bark, and leaves (4,5). Lupeol and its esters have been identified in H. drasticus and shown to present antinociceptive and anti-inflammatory effects (6).…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive and anti-inflammatory activities of a triterpene-rich fraction from Himatanthus drasticus

de-Almeida

da-Silva

Sousa

et al. 2019

Braz J Med Biol Res

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Himatanthus drasticus (Mart.) Plumel belongs to the Apocynaceae family and the latex from its trunk bark ( Hd ) is known as “janaguba milk”. This latex is widely used in Northeast Brazil, mainly in the Cariri region, for its gastroprotective, anti-inflammatory, and antitumor properties. The objective of this study was to investigate a triterpene-rich fraction (FJNB) from H. drasticus latex on acute models of nociception and inflammation and to clarify its mechanisms of action. Wistar rats or Swiss mice were subjected to the carrageenan-induced paw edema test or the formalin test, respectively, after the acute oral treatment with FJNB. The inflamed paws from the carrageenan-induced paw edema and formalin tests were processed for histological and immunohistochemical assays, respectively. The results were analyzed by ANOVA and considered significant at P<0.05. FJNB (10 mg/kg) decreased the paw edema by 25% at the 3rd h after the carrageenan injection. Indomethacin, used as reference, inhibited the paw edema by 59% at the same time-point. In the formalin test, FJNB inhibited the 1st phase by 27, 49, and 52% and the 2nd phase by 37, 50, and 67%, at the doses of 1, 5, and 10 mg/kg, respectively. In addition, FJNB significantly inhibited the expressions of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and the inflammatory cytokine tumor necrosis factor (TNF)-alpha. The histone deacetylase (HDAC) expression and the transcription factor nuclear factor kappa (NF-kB) were also inhibited at the same doses. In conclusion, the FJNB inhibitory actions on iNOS, COX-2, TNF-α, HDAC, and NF-kB could be involved with the drug anti-inflammatory activity.

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Himatanthus Willd. ex Schult. (Apocynaceae): Review

Cited by 11 publications

References 34 publications

O efeito cicatrizante do extrato etanólico das folhas de Himatanthus obovatus (Müll Arg.) Woodson

O efeito cicatrizante do extrato etanólico das folhas de Himatanthus obovatus (Müll Arg.) Woodson

Phytochemical Screening of Himatanthus sucuuba (Spruce) Woodson (Apocynaceae) Latex, In Vitro Cytotoxicity and Incision Wound Repair in Mice

Antinociceptive and anti-inflammatory activities of a triterpene-rich fraction from Himatanthus drasticus

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