Background: Total hip arthroplasty (THA) for bony ankylosis is technically challenging in patients with ankylosing spondylitis (AS). This study aimed to determine the mid-term results of bilateral synchronous THA for bony ankylosis in patients with AS.Methods: Nineteen cases of bony ankylosis in patients with AS who received bilateral synchronous THA were included in this study (17 males and 2 females, mean age 49.2 years). Disease duration was 5–38 years (mean 18 years and 6 months). All patients received cementless THA. Intraoperative blood loss, visual analogue scale (VAS) score, and complications were assessed. Harris hip scores evaluated the clinical effect.Results: Patients were followed up for 62–98 months (mean 82.5 months). VAS score decreased from 7.42±0.92 to 2.42±0.83, Harris hip score improved from 21.8±7.2 to 80.3±6.5, and the flexion-extension range of the hip improved from 0°to 142.3±6.2°. One patient with septum bronchiale had a fracture intraoperatively and was treated with wire strapping. One patient had a traction injury of the femoral nerve postoperatively and recovered 1 year after the operation. Loosening and subsidence were not observed in all patients. Heterotopic bone formation was noted in 3 patients. No complications such as joint dislocation, acute infection, and deep vein thrombosis were found.Conclusion: Bilateral synchronous THA was effective for bony ankylosis of the hip in patients with AS because it improved patients’ quality of life, and had satisfactory mid-term outcomes.